A5101526518- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Nutrition and Health in Aging
- Cardiac, Anesthesia and Surgical Outcomes
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Liver physiology and pathology
- Immune Response and Inflammation
- Cancer, Lipids, and Metabolism
- Nanoplatforms for cancer theranostics
- Cancer Mechanisms and Therapy
- Plant Pathogens and Fungal Diseases
- Photodynamic Therapy Research Studies
- Nitric Oxide and Endothelin Effects
- Mycotoxins in Agriculture and Food
- Cancer, Hypoxia, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Cancer Research and Treatments
- NF-κB Signaling Pathways
- interferon and immune responses
Kansai Medical University
2015-2025
Nagoya University
2019-2024
The University of Tokyo
2014-2023
Nagasaki University Hospital
2016-2022
Hiroshima City Asa Citizens Hospital
2021
Toyo University
2017-2020
Nagasaki University
2016-2018
Daicel (Japan)
2018
Jikei University School of Medicine
2018
Shimane University Hospital
2013
s of Articles on Computed Tomography from Non-Radiological Journals: RADIOCHEMISTRY: PDF Only
Interleukin-1 receptor–associated kinase 4 (IRAK-4) was reported to be essential for the Toll-like receptor (TLR)– and T cell (TCR)–mediated signaling leading activation of nuclear factor κB (NF-κB). However, importance activity IRAK family members is unclear. In this study, we investigated functional role IRAK-4 in vivo by generating mice carrying a knockin mutation (KK213AA) that abrogates its activity. IRAK-4KN/KN were highly resistant TLR-induced shock response. The cytokine production...
During inflammation, inducible nitric oxide synthase (iNOS) is induced to generate the important mediator (NO). Interleukin 1β (IL-1β) induces iNOS messenger RNA (mRNA), protein, and NO in rat hepatocytes. We found that stability of mRNA changed during induction antisense (AS) strand corresponding 3′-untranslated region (3′UTR) was transcribed from gene. Expression levels AS transcript correlated with those mRNA. The 1.5-kilobase 3′-flanking gene exon 27 involved IL-1β induction. Knockdown...
Abstract Background and Objectives Microvascular invasion (MVI) is difficult to detect before resection of hepatocellular carcinoma (HCC). Methods Clinicopathological outcome data were retrospectively compared between 213 HCC patients with MVI 221 without who underwent hepatectomy. Results risk was selected as an independent prognostic indicator for both disease‐free overall survival in our 434 patients. Univariate multivariate analyses showed that age under 65 years, a protein induced by...
Abstract TANK-binding kinase 1 (TBK1) and inducible IκB (IKK-i) are involved in the activation of transcription factors inducing production type I IFNs. Although TBK1, but not IKK-i, is critical for LPS-induced IFN induction, role these kinases responses against viral infection yet to be determined. In this study, we show that various RNA viruses was completely abrogated conventional dendritic cells (DCs) macrophages induced from fetal liver lacking both TBK1 whereas considerable amounts...
Abstract Background and Objectives Aging of the population has significantly increased number elderly patients undergoing surgery for hepatocellular carcinoma (HCC). We aimed to compare results hepatectomy HCC in ≥70 years old with those younger patients. Methods Clinicopathological data outcomes 155 333 who underwent between 1992 2007 were retrospectively compared. Results The group had a higher incidence associated diseases, but better preoperative liver function. Although postoperative...
Background Recent meta-analyses concluded that antibiotic prophylaxis is not warranted in low-risk laparoscopic cholecystectomy. However, most trials the had a relatively small sample size and were statistically underpowered. In addition, many of mentioned potential cost savings owing to elimination prophylactic antibiotics. no trial has estimated effectiveness. To evaluate results meta-analyses, we conducted randomized controlled on role antibiotics cholecystectomy with an adequate size....
Background/Objectives: Postoperative analgesia is important for reducing biologically invasive reactions to surgery. In Japan, postoperative analgesia, including indices of has not been adequately addressed. This study aimed determine the relationship between pain and course importance early recovery. Methods: Patients who underwent any seven surgical procedures in gastrointestinal, thoracic, cardiac surgery were enrolled. The primary endpoint was a median Prince Henry Pain Scale score from...
Abstract Aim This study aimed to evaluate the impact of infusion timing time‐of‐day on clinical outcomes in patients with unresectable hepatocellular carcinoma (HCC) treated atezolizumab plus bevacizumab combination therapy. Methods A retrospective analysis was conducted using data from 751 HCC between September 2020 and April 2024. Patients were categorized into morning (AM; n = 351) afternoon (PM; 400) groups based time‐of‐day. Outcomes, including progression‐free survival (PFS), overall...
Background and Aim: We investigated the association between pretreatment cachexia index (CXI) survival outcomes in patients with unresectable hepatocellular carcinoma (u-HCC) receiving atezolizumab plus bevacizumab (Atez/Bev). Methods: conducted a retrospective analysis of 195 u-HCC treated Atez/Bev from September 2020 to December 2023. The skeletal muscle mass (SMI) was calculated by normalizing psoas area square height (cm²/m²). CXI defined as SMI × serum albumin level...
Vibrio parahaemolyticus, causative agent of human gastrointestinal diseases, possesses several virulent machineries including thermostable direct hemolysin and type III secretion systems (TTSS1 -2). In this report, we establish that TTSS1-dependent translocation a V. parahaemolyticus effector protein VP1686 into the cytosol induces DNA fragmentation in macrophages. We performed yeast two-hybrid screening to identify molecules involved VP1686-mediated cell death pathways showed nuclear factor...