A5026105894- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Nutrition and Health in Aging
- Esophageal and GI Pathology
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Frailty in Older Adults
- Neuroendocrine Tumor Research Advances
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Intraperitoneal and Appendiceal Malignancies
- Metastasis and carcinoma case studies
- Neutropenia and Cancer Infections
- Anesthesia and Sedative Agents
- Multiple and Secondary Primary Cancers
- Antifungal resistance and susceptibility
- Synthesis and Reactions of Organic Compounds
- Hepatitis C virus research
- Fluorine in Organic Chemistry
Shiga University of Medical Science
2017-2024
Nara City Hospital
2024
Jikei University School of Medicine
2024
Dokkyo Medical University
2023
Aichi Cancer Center
2021
Ehime University
1984-2020
Ogaki Municipal Hospital
2016-2017
Mitsui Chemicals (Germany)
1977-2011
Tokyo Women's Medical University Hospital
1997-2000
Tokyo Metropolitan Institute of Gerontology
1992
Abstract The toxicity and tumor affinity of 5-fluorouracil (1) have been modified by the introduction a carbamoyl group. Carbamoylation three general methods were studied extensively: (i) reaction 1 with isocyanate, (ii) 1-chloroformyl-5-fluorouracil amine, (iii) chloride. These usually give -carbamoyl-5-fluorouracils (2). 3-Carbamoyl-5-fluorouracils not obtained any method. 2 substances take hydrogen-bonded structure in chloroform, non DMSO at 80 °C, mixed structures 25 °C. Thirty-six...
Summary Aim : To investigate the inhibitory effects on gastric acid secretion of three proton pump inhibitors, omeprazole, lansoprazole and rabeprazole, using a three‐way crossover design in healthy Helicobacter pylori ‐negative,S‐mephenytoin 4′‐hydroxylase (CYP2C19) homo‐ hetero‐extensive metabolizers. Methods Eight Japanese male volunteers were enrolled. After administration rabeprazole (10 mg/day), (30 mg/day) or omeprazole (20 intragastric pH monitoring was commenced from 24 h before...
Abstract Background Approximately 20% of lung adenocarcinoma (LUAD) is negative for the lineage-specific oncogene Thyroid transcription factor 1 (TTF-1) and exhibits worse clinical outcome with a low frequency actionable genomic alterations. To identify molecular features associated TTF-1–negative LUAD, we compared transcriptomic proteomic profiles LUAD cell lines. SRGN , chondroitin sulfate proteoglycan Serglycin, was identified as markedly overexpressed gene in LUAD. We therefore...
<b><i>Introduction:</i></b> Microbiomes play a vital role in the development and progression of cancer. The clinical status, including prognosis, genetic mutations, sensitivity to chemotherapy, differs depending on location colorectal cancer (CRC); however, association between gut microbiota CRC is not entirely understood. This study was conducted evaluate differences patients with according tumor. <b><i>Methods:</i></b> Fifty-six who underwent...
Background: Spasticity is an upper motor neuron syndrome that exacerbates paralysis and rarely associated with pain. This report elucidates the management of drug-resistant pain attributed to adolescent brain tumor using botulinum therapy. Case presentation: A 15-year-old female patient experienced dizziness, developed muscle weakness in her extremities, was diagnosed diffuse glioblastoma pons. The responded partially radiation Three years later, at time recurrence, she had high tone...
The aim of this study was to assess the relationship between computed tomography (CT) pancreatic parenchyma attenuation value and clinically relevant postoperative fistula (POPF).The medical records 115 patients who underwent pancreaticoduodenectomy preoperative dynamic CT were retrospectively reviewed. values nonenhanced (N), arterial (A), portal venous (P), late (L) phase in determined via CT, A/N, A/P, P/L ratios calculated. compared POPF non-POPF groups.Thirty-two (28%) categorized...
The brains of 14 elderly patients who died after status epilepticus were examined pathologically. Three the showed unilateral brain damage which corresponded to side seizures, and lesions thought be caused by seizures. In these three two other patients, no causative lesion related seizures was found. five occurred during theophylline therapy thus in assumed induced theophylline. with damage, seen hippocampus, amygdala thalamus while third, whole hemisphere damaged, including amygdala,...
The toxicity and tumor affinity of 5-fluorouracil (1) have been modified by the introduction acyloxyalkyl group (s) at 1-, 3- or 1, 3-position 1. 1-Acyloxyalkyl-5-fluorouracil (3), 3-acyloxyalkyl-5-fluorouracil (4) 3-bis (acyloxyalkyl)-5-fluorouracil (5) were obtained three methods : i) reaction α-chloroalkyl carboxylate (2) with ii) alkylidene diacylate 2, 4-bis (trimethylsilyloxy)-5-fluoropyrimidine, iii) partial hydrolysis 5. Compounds 3, 4 5 showed antitumor activity.
With the aim of diminishing toxicity 5-fluorouracil (1) and obtaining biologically active derivatives 1 suitable for oral administration, α-alkoxyalkyl groups were introduced at 1-, 3-and 1, 3-positions 1. Alkoxyalkylation can be effected by four methods : (i) reaction 1-alkoxyalkyl chloride (2) with (ii) acetal 2, 4-bis (trimethylsiloxy)-5-fluoropy-rimidine, (iii) addition α-unsaturated ether (iv) aminolysis 1-alkylthio-carbonyl-3-(1-alkoxyalkyl)-5-fluorouracil. The products was less than...
Synchronous double cancer of the gallbladder and pancreas that is associated with congenital biliary dilatation (CBD) pancreaticobiliary maljunction (PBM) extremely rare. PBM frequently reported in Asia, particularly Japan. We report a surgical case synchronous patient primary pancreatic cancer.A 72-year-old woman epigastralgia underwent subtotal stomach-preserving pancreaticoduodenectomy bed resection for head cancer. Histopathological examination revealed moderately differentiated ductal...
Abstract Background The rectal and vaginal walls are typically sutured if severe perineal lacerations with mucosal damage occur during delivery. In case of anal incontinence after the repair, re-suturing sphincter muscle is standard procedure. However, this procedure may not result in sufficient improvement function. Case presentation A 41-year-old woman underwent suture repair for fourth-degree laceration at She was referred to our department complaining flatus fecal incontinence. Her...
The presence of tumor-infiltrating lymphocytes (TILs) has been demonstrated as a prognostic factor in colorectal cancer after surgical resection malignancy, but knowledge on their role pancreatic is lacking. Immunoscore (IS) assesses TILs at the core tumor (CT) and invasive margin (IM) being evaluated new concept immunity. aim this study was to evaluate relationship between IS prognosis PDAC.
Adjuvant chemotherapy is a standard therapeutic option for resected pancreatic cancer. However, the risk factors incompletion of adjuvant remain unclear.