A5066746003- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Parkinson's Disease Mechanisms and Treatments
- Skin Protection and Aging
- melanin and skin pigmentation
- Nerve injury and regeneration
- Medical Imaging Techniques and Applications
- Neurological disorders and treatments
- Forensic Toxicology and Drug Analysis
- Phytochemicals and Antioxidant Activities
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Mesenchymal stem cell research
- Advanced MRI Techniques and Applications
- Pain Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- Treatment of Major Depression
- Anatomy and Medical Technology
- Biochemical Analysis and Sensing Techniques
- Wound Healing and Treatments
- Attention Deficit Hyperactivity Disorder
- Receptor Mechanisms and Signaling
- Biotin and Related Studies
- Spinal Cord Injury Research
National Defense Medical Center
2015-2024
Tri-Service General Hospital
2016-2023
Taoyuan Armed Forces General Hospital
2022-2023
National Defence University
2021
Union Hospital
2018-2019
Huazhong University of Science and Technology
2018-2019
Hypertrophic scarring is related to persistent activation of transforming growth factor-β (TGF-β)/Smad signaling. In the TGF-β/Smad signaling cascade, TGF-β type I receptor (TGFBRI) phosphorylates Smad proteins induce fibroblast proliferation and extracellular matrix deposition. this study, we inhibited TGFBRI gene expression via small interfering RNA (siRNA) reduce Our results demonstrate that downregulating in cultured human hypertrophic scar fibroblasts significantly suppressed cell...
Abstract Background Mitochondria are essential organelles involved in cellular energy production. Changes mitochondrial function can lead to dysfunction and cell death aging age-related disorders. Recent research suggests that is closely linked neurodegenerative diseases. Glucagon-like peptide-1 receptor (GLP-1R) agonist has gained interest as a potential treatment for Parkinson's disease (PD). However, the exact mechanisms responsible therapeutic effects of GLP-1R-related agonists not yet...
// Cheng-Yu Yang 1, 6 , Chih-Kung Lin 3 Chang-Huei Tsao 7, 8 Cheng-Chih Hsieh 5 Gu-Jiun 4 Kuo-Hsing Ma Yi-Shing Shieh Huey-Kang Sytwu 7 and Yuan-Wu Chen 2, 1 Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan 2 Department Oral Maxillofacial Surgery, Tri-Service General Hospital, Division Anatomic Pathology, Taipei Tzu Chi Biology Anatomy, Pharmacy Practice, School Dentistry, Microbiology Immunology, Research, Correspondence to: Chen, email:...
Abstract In this study, we characterized the effect of baicalein on regulation keratinocyte differentiation and proliferation, which are abnormal in atopic dermatitis or psoriasis. Treatment HaCaT keratinocytes with 10 μ m slightly inhibited cell growth, caused morphological increased expression keratins 1 (K1/K10) without affecting ROS generation, cytochrome c release apoptosis. Baicalein treatment growth arrest G 0 /G phase also induced Ca 2+ influx via TRPV 4 receptor activation....
The advent of virtual reality (VR) in education offers unique possibilities for facilitating cooperative learning strategies, particularly fields demanding intricate spatial understanding, such as gross anatomy. This study investigates the impact integrating strategies within a VR-based anatomy curriculum, focusing on enhancing students' knowledge and skills. We analyzed performance two cohorts first-year nursing students across five semesters (2016-2020), where traditional methods were used...
Autophagic (type II) cell death, characterized by the massive accumulation of autophagic vacuoles in cytoplasm cells, has been suggested to play pathogenetic roles cerebral ischemia, brain trauma, and neurodegenerative disorders. 3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is an illicit drug causing long-term neurotoxicity brain. Apoptotic I) necrotic III) death have implicated MDMA-induced neurotoxicity, while role autophagy MDMA-elicited not investigated. The present study aimed...
Baicalein is a flavonoid inhibitor of 12-lipoxygenase. Here, we investigated its effect on hydrogen peroxide-induced damage to NG108-15 cells. Hydrogen peroxide activated the mitochondrial apoptotic pathway, decreased Nrf2 expression, increased reactive oxygen species (ROS) levels, reduced viability, and cell death after 2-24 h treatment Co-treatment with baicalein completely suppressed activation pathway by upregulating expression reducing ROS stress partially inhibited effects viability...
Advanced oral cancer is a major public health concern because of lack effective prevention and treatment. Triptolide (TPL), diterpenoid triepoxide derived from the Chinese herb Tripterygium wilfordii, has been demonstrated to possess strong anticancer properties. In this study, we investigated whether TPL exerts effects on tumor microenvironment head neck squamous cell carcinoma (HNSCC).Human macrophage-like U937 cells were co-inoculated with SAS in noncontact transwell coculture system....
Increased matrix metalloproteinase 1 (MMP-1) expression is a feature of photo-aged skin. We investigated the effects baicalein and sulphoraphane on ultraviolet B (UVB) irradiation-induced MMP-1 apoptosis using human dermal fibroblasts. UVB irradiation not only increased expression, but also caused apoptosis. Both protected cells from apoptosis, inhibited expression. activated 12-lipoxygenase, its product, 12-hydroxyeicosatetraenoic acid, TRPV1 channels. The resulting Ca2+ increase was...
Bezafibrate, a pan-peroxisome proliferator-activated receptor (PPAR) agonist, reportedly attenuated tau pathology in transgenic mouse model of primary tauopathy. Since is neuropathological hallmark Alzheimer's disease (AD), bezafibrate may be potential drug for the treatment AD. However, no study has investigated its effects AD models. Thus, we aimed to evaluate whether neuroprotective sporadic induced by streptozotocin (STZ) intracerebroventricular (ICV) injection. Rats were administered...
Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although activity critically involved studies observing this relationship are limited. Thus current study examined whether availability associated with developing dependence dysfunction. Brain imaging 99mTc-TRODAT-1 as a ligand was used to measure among 26 male patients pure 22 age- sex- matched healthy volunteers. The Wisconsin Card Sorting...
To treat skin color disorders, such as vitiligo or burns, melanocytes are transplanted for tissue regeneration. However, melanocyte distribution in the human body varies with age and location, making it difficult to select optimal donor achieve a desired match. Determining correlations measurement based on CIELAB color, epidermal numbers, melanin content of individual is critical clinical application.Fifteen foreskin samples from Asian young adults were analyzed ratio (melanocyte proportion...
Serotonin (5-HT) plays a crucial role in modulating the afferent fiber discharge rate inferior colliculus, auditory cortex, and other nuclei of ascending system. Resveratrol, natural polyphenol phytoalexin, can inhibit serotonin transporters (SERT) to increase synaptic 5-HT levels. In this study, we investigated effects resveratrol on noise-induced damage serotonergic Male Sprague-Dawley rats were anaesthetized exposed an 8-kHz tone at 116 dB for 3.5 h. Resveratrol (30 mg/kg, intraperitoneal...
The serotonin (5-HT) system can manipulate the processing of exogenous L-DOPA in DA-denervated striatum, resulting modulation L-DOPA-induced dyskinesia (LID).
Mesenchymal stromal/stem cells (MSCs) are widely distributed in different tissues such as bone marrow, adipose tissues, peripheral blood, umbilical cord and amnionic fluid. Recently, MSC-like were also found to exist rat olfactory bulb capable of inducing differentiation into mesenchymal lineages - osteocytes, chondrocytes adipocytes. However, whether these can differentiate myocardial is not known. In this study, we examined bulb-derived MSCs could vitro. Fibroblast-like isolated from the...