A5101423839- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Nerve injury and regeneration
- Medical Imaging Techniques and Applications
- Receptor Mechanisms and Signaling
- Forensic Toxicology and Drug Analysis
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer Treatment and Pharmacology
- Hearing Loss and Rehabilitation
- Biochemical Analysis and Sensing Techniques
- Radiopharmaceutical Chemistry and Applications
- Nuclear Receptors and Signaling
- Synthesis and Biological Evaluation
- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Parkinson's Disease Mechanisms and Treatments
National Defense Medical Center
2012-2019
Tri-Service General Hospital
2012-2019
University of Pennsylvania
1996-2003
Serotonin (5-HT) plays a crucial role in modulating the afferent fiber discharge rate inferior colliculus, auditory cortex, and other nuclei of ascending system. Resveratrol, natural polyphenol phytoalexin, can inhibit serotonin transporters (SERT) to increase synaptic 5-HT levels. In this study, we investigated effects resveratrol on noise-induced damage serotonergic Male Sprague-Dawley rats were anaesthetized exposed an 8-kHz tone at 116 dB for 3.5 h. Resveratrol (30 mg/kg, intraperitoneal...
[11C]McN5652 has been reported to exhibit favorable properties as a PET radiotracer for studying serotonin uptake sites. However, the use of this may be limited by short half-life of11C. To obtain tracer with longer physical half-life, we have synthesized S-[18F]fluoroethyl analog McN5652 (trans-1,2,3,5,6,10b-hexahydro-6-[4-([18F]fluoroethylthio)-phenyl] pyrrolo-[2,1-a]-isoquinoline) ([18F]FEMcN) and evaluated imaging The radiosynthesis was performed via one-pot, two-step procedure. In first...
Parkinson's disease (PD) is a neurodegenerative characterized by loss of dopaminergic neurons in the nigrostriatal pathway. Apart from effective strategies to halt underlying neuronal degeneration, cell replacement now offers novel prospects for PD therapy. Porcine embryonic neural tissue has been considered an alternative source human fetal grafts disorders because its use avoids major practical and ethical issues. This study was undertaken evaluate effects day 27 (E27) porcine...
The pathology of Parkinson's disease (PD) results mainly from nigrostriatal pathway damage. Unfortunately, commonly used PD therapies do not repair the disconnected circuitry. It has been reported that using kainic acid (KA, an excitatory amino acid) in bridging transplantation may be useful to generate artificial tract and reconstruct 6-hydroxydopamine (6-OHDA) lesioned rats. In this study, we KA a co-graft rat olfactory ensheathing cells (OECs) E14 embryonic ventral mesencephalic (VM)...