A5066373753- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Virus-based gene therapy research
- Medical Imaging and Pathology Studies
- Histone Deacetylase Inhibitors Research
- Glioma Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Medical Image Segmentation Techniques
- MicroRNA in disease regulation
- Psoriasis: Treatment and Pathogenesis
- Advanced X-ray and CT Imaging
- Cardiac Imaging and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Thyroid Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
Taipei Veterans General Hospital
2014-2023
Cheng Hsin General Hospital
2019-2023
National Yang Ming Chiao Tung University
2013-2022
National Yang Ming University Hospital
2011-2021
Electronics Testing Center
2013-2021
National Taiwan University
2020
GTx (United States)
2019
Laboratoire d’Imagerie Biomédicale
2017
National Defense Medical Center
1995-2016
National Taipei University
2011-2015
The accumulation of extracellular β-amyloid (Aβ) plaques within the brain is unique to Alzheimer’s disease (AD) and thought induce synaptic deficits neuronal loss. Optimal therapies should tackle core AD pathophysiology prevent decline in memory cognitive functions. This study aimed evaluate therapeutic performance mesenchymal stem cell-derived exosomes (MSC-exosomes), which are secreted membranous elements encapsulating a variety MSC factors, on AD. A human neural cell culture model with...
CLEC5A/MDL-1, a member of the myeloid C-type lectin family expressed on macrophages and neutrophils, is critical for dengue virus (DV)-induced hemorrhagic fever shock syndrome in Stat1⁻/⁻ mice ConA-treated wild type mice. However, whether CLEC5A involved pathogenesis viral encephalitis has not yet been investigated. To investigate role to regulate JEV-induced neuroinflammation, antagonistic anti-CLEC5A mAb CLEC5A-deficient were generated. We find that Japanese (JEV) directly interacts with...
Background Cycling and chronic tumor hypoxia are involved in development growth. However, the impact of cycling its molecular mechanism on glioblastoma multiforme (GBM) progression remain unclear. Methodology Glioblastoma cell lines, GBM8401 U87, their xenografts were exposed to hypoxic stress vitro vivo. Reactive oxygen species (ROS) production cells was assayed by ROS analysis vivo imaging studies. NADPH oxidase subunit 4 (Nox4) RNAi-knockdown technology utilized study role Nox4...
Triple-negative breast cancer (TNBC) represents approximately 20% of all cancers and appears resistance to conventional cytotoxic chemotherapy, demonstrating a particularly poor prognosis significantly worse clinical outcome than other types cancer. Suicide gene therapy has been used for the in vivo treatment various solid tumors recent trials. In tumor microenvironment, STAT3/NF-κB pathways are constitutively activated stromal cells as well stem (CSCs). this study, we have cloned novel...
// Muh-Lii Liang 1,2,* , Tsung-Han Hsieh 3,4,* Kim-Hai Ng 5 Ya-Ni Tsai Cheng-Fong 6 Meng-En Chao 7,8 Da-Jung Liu 2 Shing-Shiung Chu Wan Chen Yun-Ru 4,9 Ren-Shyan 10,11,12 Shih-Chieh Lin 13 Donald Ming-Tak Ho 10,13 Tai-Tong Wong 2,7,8,9 Muh-Hwa Yang 1,14,15,16,17 and Hsei-Wei Wang 1,5,6,14 1 Institutes of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan Division Pediatric Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, 3 PhD Program for Cancer Biology...
Ataxia is one of the most devastating symptoms many neurodegenerative disorders. As today, there not any effective treatment to retard its progression. Mesenchymal stem cells (MSCs) have shown promise in treating diseases. We hereby report results a phase I/IIa clinical study conducted Taiwan primarily evaluate safety, tolerability, and, secondarily, possible efficacy intravenous administration allogeneic adipose tissue-derived MSCs from healthy donors. Six patients with spinocerebellar...
Sorafenib is effective for patients with advanced hepatocellular carcinoma (HCC) and particularly those who are unsuitable to receive life-prolonging transarterial chemo-embolization. The survival benefit of sorafenib, however, unsatisfactory. Vorinostat also known as suberoylanilide hydroxamic acid (SAHA) a histone deacetylase (HDAC) inhibitor anti-HCC efficacy in preclinical studies. SAHA induces nuclear factor κ-light-chain-enhancer activated B cells (NF-κB) activity vitro, which may lead...
Photochemically induced cerebral ischemia is an easy-manipulated, reproducible, relatively noninvasive, and lesion controllable model for translational study of ischemic stroke. In order to longitudinally investigate the characterization model, magnetic resonance imaging, 18F-2-deoxy-glucose positron emission tomography, fluorescence, bioluminescence imaging system were performed in correlation with triphenyl tetrazolium chloride (TTC), hematoxylin-eosin staining, immunohistochemistry...
Hypoxia-inducible factor 1α (HIF-1α) controls many genes involved in physiological and pathological processes. However, its roles glutamatergic transmission excitotoxicity are unclear. Here, we proposed that HIF-1α might contribute to glutamate-mediated during cerebral ischaemia–reperfusion (CIR) investigated molecular mechanism. We showed an conditional knockout mouse displayed inhibition CIR-induced elevation of extracellular glutamate N-methyl-d-aspartate receptor (NMDAR) activation. By...
The diagnosis of brain metastasis (BM) is commonly observed in non-small cell lung cancer (NSCLC) with poor outcomes. Accordingly, developing an approach to early predict BM response Gamma Knife radiosurgery (GKRS) may benefit the patient treatment and monitoring. A total 237 NSCLC patients BMs (for survival prediction) 256 976 prediction local tumor control) treated GKRS were retrospectively analyzed. All data recorded without censoring, status control was determined by comparing last MRI...
Measurement of the local cerebral metabolic rate glucose (LCMRGlc) and individual constant parameters [(18 )F]2-fluoro-2-deoxy-D-glucose (FDG) model can provide a clearer understanding insight to physiological processes in human brain, quicker more accurate means diagnosis clinical applications. A systematic study using simulated tissue time activity data is presented evaluate several existing newly developed major algorithms used for determining LCMRGlc constants from positron emission...
This study aimed to define the potential of 1-<sup>11</sup>C-acetate PET, compared with <sup>18</sup>F-FDG, in detecting meningiomas and monitoring effect γ-knife radiosurgery. <b>Methods:</b> Twenty-two patients neuroradiologic diagnosis meningioma were examined by <sup>18</sup>F-FDG PET on same day. There 12 cases histopathologically proven (8 grade I, 2 II, III), 1 tuberculous granuloma, degenerative tissue. scans fasting obtained 10 min after intravenous administration 740 MBq...
Abstract Purpose: Metastasis is the major cause of death in patients with colorectal cancer (CRC). Circulating tumor cells (CTC) are believed to metastasis and serve as a prognostic marker for mortality clinical stage IV patients. However, most studies conducted late-stage cases when distant metastases have already occurred; thus, such results provide limited use. This study focused on whether CTCs can predict risk after treatment primary early-stage CRC. Experimental Design: were quantified...
Adoptive T-cell therapy involves the ex vivo expansion and subsequent transfusion of tumor-specific T lymphocytes to eliminate tumors. Using immune modulators block immunosuppressive factors in tumor microenvironment has emerged as a promising strategy enhance T-cell-mediated regression. Curcumin, major component turmeric, been shown possess antitumor immunomodulatory effects by regulating diverse range molecular targets. Thus, we hypothesize that these beneficial curcumin may improve...
MR Features of Abdominal SplenosisWen-Chiung Lin1 2, Rheun-Chuan Lee1 Jen-Huey Chiang1 Chao-Jung Wei1 Lee-Shing Chu3 4, Ren-Shyan Liu3 4 and Cheng-Yen Chang1 2 5Audio Available | Share
Requirements of large numbers transferred T cells and various immunosuppressive factors in the tumor microenvironment limit applications adoptive therapy (ACT) clinic. Accumulating evidences show that chemotherapeutic drugs could act as immune supportive instead agents when proper dosage is used, combined with immunotherapy often results better treatment outcomes than monotherapy. Controversial immunomodulation effects sorafenib, a multi-kinases inhibitor, at high low doses have been...
Osteoclasts are bone tissue macrophages critical to maintain homeostasis. However, whether osteoclasts susceptible flaviviral infections and involved in dengue virus (DV)-induced disease pathogenesis is still unknown. In this study, we found that were preferentially DV infection produced similar amounts of cytokines infectious virions as macrophages. Interestingly, DV-induced cytokine secretion nuclear translocation the transcription factor NFATc1 osteoclast via Syk-coupled myeloid C-type...