A5103144494- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- COVID-19 Clinical Research Studies
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Parvovirus B19 Infection Studies
- SARS-CoV-2 and COVID-19 Research
- Circular RNAs in diseases
- Viral-associated cancers and disorders
- Drug Transport and Resistance Mechanisms
- FOXO transcription factor regulation
- Genomics, phytochemicals, and oxidative stress
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- PARP inhibition in cancer therapy
- ATP Synthase and ATPases Research
- Cancer Research and Treatments
- Diabetes Treatment and Management
- PI3K/AKT/mTOR signaling in cancer
Taipei Veterans General Hospital
2025
Tzu Chi Foundation
2021-2024
Tzu Chi University
2022-2024
Taipei Medical University Hospital
2024
Hebei North University
2023
China Medical University
2013-2022
Bharathiar University
2022
Chang Gung University
2012-2022
Kaohsiung Chang Gung Memorial Hospital
2022
Taichung Veterans General Hospital
2022
Tumor cycling hypoxia is now a well-recognized phenomenon in animal and human solid tumors. However, how tumor impacts chemotherapy unclear. In the present study, we explored impact mechanism of on microenvironment-mediated chemoresistance. Hoechst 33342 staining hypoxia-inducible factor-1 (HIF-1) activation labeling together with immunofluorescence imaging fluorescence-activated cell sorting were used to isolate hypoxic subpopulations from glioblastoma xenografts. ABCB1 expression,...
Cycling hypoxia is a well-recognized phenomenon within animal and human solid tumors. It contributes to the resistance cytotoxic therapies through anti-apoptotic effects. However, mechanism underlying cycling hypoxia-mediated anti-apoptosis remains unclear. Reactive oxygen species (ROS) production, activation of hypoxia-inducible factor-1 alpha (HIF-1α) nuclear factor-κB (NF-κB) signaling pathways, B-cell lymphoma extra-long (Bcl-xL) expression, caspase activation, apoptosis in vitro hypoxic...
Hypoxia-inducible factor 1α (HIF-1α) controls many genes involved in physiological and pathological processes. However, its roles glutamatergic transmission excitotoxicity are unclear. Here, we proposed that HIF-1α might contribute to glutamate-mediated during cerebral ischaemia–reperfusion (CIR) investigated molecular mechanism. We showed an conditional knockout mouse displayed inhibition CIR-induced elevation of extracellular glutamate N-methyl-d-aspartate receptor (NMDAR) activation. By...
Abstract Purpose: Tumor hypoxia is one of the crucial microenvironments to promote therapy resistance (TR) in glioblastoma multiforme (GBM). Livin, a member family inhibitor apoptosis proteins, contributes antiapoptosis. However, role tumor Livin regulation and its impact on TR are unclear. Experimental Design: expression for hypoxic cells derived from human xenografts or vitro stress-treated were determined by Western blotting, immunofluorescence imaging, annexin V staining assay. The...
Virtual microscopy (VM) has been utilized to improve students' learning experience in microscope laboratory sessions, but minimal attention given determining how use VM more effectively. The study examined the influence of on academic performance and teacher student perceptions compared test scores before after incorporation. A total 662 third‐year students studying histology 651 fourth‐year pathology were divided into two groups. light (LM) group used a 2014 2015, while LM + platform 2016...
Background: Unlike conventional photon radiotherapy, particle therapy has the advantage of dose distribution. Carbon-ion radiotherapy is also advantageous in terms biological effectiveness and other radiobiological aspects. These benefits lead to a higher response probability for previously known radioresistant tumor types. Therefore, Taipei Veterans General Hospital, which located northern district Taipei, built first carbon-ion irradiation facility Taiwan. Methods: Hospital completed phase...
Forkhead box C1 (FOXC1) is a member of the forkhead family transcription factors that are characterized by DNA-binding domain.Increasing evidence indicates FOXC1 involved in tumor progression.However, role hypoxia regulation and its impact on lung cancer progression unclear.Here, we report was upregulated hypoxic areas tissues from rodents or humans.Hypoxic stresses significantly induced expression.Moreover, activated via direct binding hypoxia-inducible factor-1α (HIF-1α) to...
Common characteristics of aging include reduced somatic stem cell number, susceptibility to cardiac injuries, metabolic imbalances and increased risk for oncogenesis. In this study, Pleiotropic anti-aging effects a decoction Jing Si herbal drink (JS) containing eight Traditional Chinese Medicine based herbs, with known against related disorders was evaluated. Adipose derived mesenchymal cells (ADMSCs) from 16 week old adult 24 month WKY rats were evaluated the age-related changes in...
Parkinsonâs disease (PD) is a common disorder attributed to the loss of midbrain dopamine (mDA) neurons and reduced secretion. Currently, treatment regimes for PD comprise deep brain stimulations, however, it attenuates progression marginally does not improve neuronal cell death. We investigated function Ginkgolide A (GA) reinforce Whartonâs Jelly-derived mesenchymal stem cells (WJMSCs) treating in vitro model PD. GA enhanced self-renewal, proliferation, homing WJMSCs as assessed by MTT...
We aimed to investigate the long-term impact of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on thyroid function, cardiovascular health, renal outcomes and adverse events in individuals with obesity without type 2 diabetes (T2D).
Coronavirus disease 2019 (COVID-19) is a worldwide health threat that has long-term effects on the patients and there currently no efficient cure prescribed for treatment prolonging effects. Traditional Chinese medicines (TCMs) have been reported to exert therapeutic effect against COVID-19. In this study, of Jing Si herbal tea (JSHT) COVID-19 infection associated were evaluated in different vitro vivo models. The anti-inflammatory JSHT studied lipopolysaccharide (LPS)-stimulated RAW 264.7...
Abstract Lung cancer is one of the most common cancers in world. Chemotherapy a standard clinical treatment. However, tumor cells often develop multidrug resistance after chemotherapy, an inevitable bottleneck Therefore, this study used gemcitabine‐resistant (GEM‐R) CL1‐0 lung cells. First, we flow cytometry and western blot analysis to examine differences performance between resistant parental The results showed that compared with cells, GEM‐R significantly enhanced activation AKT pathway,...
Rationale: Although molecular investigations of regulator G-protein signaling 4 (RGS4) alterations in schizophrenia patients yielded partially inconsistent findings, the previous studies suggested that RGS4 is both a positional and functional candidate gene for significantly decreased prefrontal cortex. However, exact role pathophysiology unclear. Moreover, whole genome transcription profile study showed possibility RGS4-regulated expression SLC7A11(xCT), component cysteine/glutamate...
Demethoxycurcumin (DMC), through a self-assembled amphiphilic carbomethyl-hexanoyl chitosan (CHC) nanomatrix has been successfully developed and used as therapeutic approach to inhibit cisplatin-induced drug resistance by suppressing excision repair cross-complementary 1 (ERCC1) in non-small cell lung carcinoma cells (NSCLC). Previously, DMC significantly inhibited on-target cisplatin protein, ERCC1, via PI3K-Akt-snail pathways NSCLC. However, low water solubility bioavailability of causes...
Strategies targeting endoglin are currently being investigated in clinical trials as an anti-angiogenic therapy. The redundancy between and vascular endothelial growth factor (VEGF) signaling angiogenesis was verified. Increased after anti-VEGF treatment observed patients. Treatment with endoglin-neutralizing antibody increased VEGF cells. Therefore, strategies both the pathways were applied to determine whether effects vitro. Five possible hits for identified from 2000 compounds Traditional...
Hepatocellular carcinoma is a common type of liver cancer. Resistance to chemotherapeutic agents major problem in cancer therapy. MicroRNAs have been reported development and tumor growth; however, the relationship between chemoresistance hepatocellular needs be fully investigated. Here, we treated cell line (HA22T) with histone deacetylase inhibitor establish carcinoma-resistant cells (HDACi-R) investigated molecular mechanisms HCC cells. Although could not enhance death HDACi-R but...
Abstract Mesenchymal stem cells (MSCs) are known to play a role in postnatal vasculogenesis and hold great promise for vascular regeneration. However, the mechanisms by which endothelial differentiation specification of MSCs remain unclear. We examined potential molecular atypical chemokine receptor ACKR3/CXCR7 MSC-mediated cell specification. Here, we showed that growth factor (VEGF) platelet-derived (PDGF) activate CXCR7 expression on through PDGF receptors, PDGFRα PDGFRβ-mediated...
Long non-coding RNA steroid receptor activators (LncRNA SRAs) are implicated in the β-cell destruction of Type 1 diabetes mellitus (T1D), but functional association remains poorly understood. Here, we aimed to verify role LncRNA SRA regulation β-cells. SRAs were highly expressed plasma samples and peripheral blood mononuclear cells (PBMCs) from T1D patients. was strongly upregulated by high-glucose treatment. acts as a microRNA (miR)-146b sponge through direct sequence-structure...
Abstract Context Nephropathy is a severe complication of type 1 diabetes (T1DM). However, the interaction between PDHA1-regulated mechanism and CD4+ T cells in early stage kidney tubular injury remains unknown. Objective To evaluate role PDHA1 regulation further to study its cell T1DM. Methods Plasma total RNA were collected from T1DM patients (n = 35) healthy donors 33) evaluated for neutrophil gelatinase-associated lipocalin (NGAL), molecule-1, PDHA1, biomarkers including helper (Th1)...