A5009800148- MicroRNA in disease regulation
- Bariatric Surgery and Outcomes
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Body Contouring and Surgery
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Anesthesia and Sedative Agents
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer therapeutics and mechanisms
- FOXO transcription factor regulation
- Tracheal and airway disorders
- 14-3-3 protein interactions
- Biochemical and Molecular Research
- Heat shock proteins research
- Cancer-related Molecular Pathways
- Obesity and Health Practices
Taipei Medical University
2014-2025
Taipei Medical University-Shuang Ho Hospital
2014-2025
Princess Máxima Center
2023
Fudan University Shanghai Cancer Center
2019
Shanghai Medical College of Fudan University
2019
Ministry of Health and Welfare
2016
National Yang Ming University Hospital
2015
National Yang Ming Chiao Tung University
2015
National Health Research Institutes
2014
National Taiwan University Hospital
2004-2011
Abstract Purpose: We wanted to investigate the antitumor effects and effect on angiogenesis of resveratrol in rat RT-2 gliomas. Experimental Design: glioma cells were treated with resveratrol, then cytotoxicity was assayed, apoptosis measured by flow-activated cell sorter flow cytometry, expression vascular endothelial growth factor reverse transcription-PCR. Tumor size, animal survival time, rate followed resveratrol-treated rats s.c. or intracerebral Furthermore, vitro proliferation...
Lactate dehydrogenase A (LDHA) can regulate tumorigenesis and cancer progression. Nevertheless, whether the regulation of LDHA is involved in development gemcitabine resistance PDAC has not yet been fully elucidated. Increasing studies have shown that acquired drug led to treatment failure highly attributed stem cell (CSC) properties. Therefore, we aim demonstrate functions regulatory mechanisms on properties PDAC. We investigate metabolite profiles by liquid chromatography-mass spectrometry...
Abstract Metastasis in breast cancer usually lead to the majority of deaths on clinical patients. Accordingly, diagnosis metastasis at early stage is important improve prognosis. We observed that Dicer protein levels are significant decrease highly invasive cells and correlated with poor outcomes. Following, we aim clarify molecular regulatory mechanism this phenomenon provide a new therapeutic target. In study, obtained expression invasion without affect cell stability cells. Importantly,...
Diffuse midline glioma H3K27-altered (DMG) is an aggressive, inoperable, predominantly paediatric brain tumour. Treatment strategies are limited, resulting in a median survival of only 11 months. Currently, radiotherapy (RT), often combined with temozolomide, considered the standard care but remains palliative, highlighting urgency for new therapies. Radiosensitisation by olaparib, inhibitor PARP1 and subsequently PAR-synthesis, promising treatment option. We assessed whether inhibition...
$('.header-date').hide();$('#titleAuthors').hide();$('#abstractHeader').hide(); Yi-Wen Chang 1 , 2 3 * Chih-Ming Su 4 5 Yen-Hao Yuan-Soon Ho 6 Hui-Huang Lai 7 Hsin-An Chen Min-Liang Kuo 8 Wen-Chun Hung Ya-Wen Chih-Hsiung Wu Pai-Sheng 9 Jen-Liang 10 11 12 Graduate Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan Genomics Research Center, Academia Sinica, 115, Cancer Research, Health Institutes, Miaoli 35053, Clinical Medicine, College Medical...
// Yen-Hao Su 1, * , Wen-Chien Huang 2, 3, Tse-Hung 4, 5 Yan-Jiun 6, 11 Yu-Kai Sue 7 Thanh-Tuan Huynh 8 Michael Hsiao 9 Tsan-Zon Liu 10 Alexander TH Wu Chien-Min Lin 7, 12 1 Department of Surgery, Division General Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan 2 Institute Traditional Medicine, School National Yang Ming 3 Thoracic Mackay Memorial 4 Chinese Chang Gung Keelung, Graduate Clinical Medicine Sciences, Taoyuan, 6 University Neurosurgery, University-Shuang Center for...
Aging | doi:10.18632/aging.204867. Tung-Wei Hsu, Yen-Hao Su, Hsin-An Chen, Po-Hsiang Liao, Shih Chiang Shen, Kuei-Yen Tsai, Tzu-Hsuan Wang, Alvin Chih-Yang Huang, Marthandam Asokan Shibu, Wan-Yu Shing-Chuan Shen
For many malignancies, radiation therapy remains the second option only to surgery in terms of its curative potential. However, radiation-induced tumor cell death is limited by a number factors, including adverse response microenvironment treatment and either intrinsic or acquired mechanisms evasive resistance, existence cancer stem cells (CSCs). In this study, we demonstrated that using different doses irradiation led enrichment CD133 + Mahlavu flow cytometric method. Subsequently, enriched...
Prostate cancer (CaP) is the sixth most significant killer of men in China.In this study, potential role micro-363 (miR-363) CaP development and progression was investigated.Pri-miR-363 or anti-miR-363 transfected into cells line PC-3 cells.Cell proliferation, transformation property, epithelial-to-mesenchymal transition (EMT) were evaluated by MTT, clonogenic assay, colony formation soft agar western blotting, respectively.The expression involvement c-myc, a downstream target miR-363 also...
Hepatocellular carcinoma is a common type of liver cancer. Resistance to chemotherapeutic agents major problem in cancer therapy. MicroRNAs have been reported development and tumor growth; however, the relationship between chemoresistance hepatocellular needs be fully investigated. Here, we treated cell line (HA22T) with histone deacetylase inhibitor establish carcinoma-resistant cells (HDACi-R) investigated molecular mechanisms HCC cells. Although could not enhance death HDACi-R but...
Obese patients are predisposed to rapid oxygen desaturation during tracheal intubation. We aimed compare the risk of between high-flow nasal oxygenation (HFNO) and classical facemask (FMO) sequence intubation for elective surgery in obese patients. Adults with a body mass index ≥30 kg·m−2 undergoing laparoscopic sleeve gastrectomy at medical center were randomized into HFNO group (n = 40) FMO 40). In group, used cannula receive 30 50 L·min−1 flow heated humidified 100% oxygen. received...
Background: To date, few reports have investigated the genetic alterations and clinicopathological features among gastric cancer (GC) patients with no tumor recurrence, early late recurrence following curative surgery. Methods: A total of 473 GC undergoing surgery were included. The characteristics, patient prognosis, patterns, compared between recurrence. Results: Among patients, 119 had (<2 years) 45 (≥2 years). Patients size larger than 5 cm, fewer superficial-type tumors, more...
Abstract Gemcitabine has been a commonly used therapeutic agent for treatment of pancreatic cancer. In the clinic, growing resistance to gemcitabine observed in patients with cancer, and investigation underlying mechanism is urgently required. The microRNA (miRNA)‐producing enzyme, Dicer, crucial maturation miRNAs, involved clinical aggressiveness, poor prognosis, survival outcomes various cancers, however, role Dicer acquired cancer still not clear. Here, we found that expression was...