A5003513920- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- GDF15 and Related Biomarkers
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Histone Deacetylase Inhibitors Research
- Nutrition and Health in Aging
- Ovarian cancer diagnosis and treatment
- TGF-β signaling in diseases
- Cancer-related Molecular Pathways
Icahn School of Medicine at Mount Sinai
2025
National Yang Ming Chiao Tung University
2014-2024
Taipei Veterans General Hospital
2015-2024
Cheng Hsin General Hospital
2023-2024
National Taipei University
2011-2020
National Yang Ming University Hospital
2014-2020
Wan Fang Hospital
2005
Taipei Medical University
2005
Abstract Gastric carcinoma is one of the most common types cancer in Taiwan. Somatic mitochondrial DNA (mtDNA) alteration gastric and its association with clinicopathologic features remain unclear. When we used polymerase chain reaction (PCR) direct sequencing, 15 31 (48%) carcinomas displayed somatic mutations D‐loop region, a hot spot for mtDNA human cancers. Ten (67%) cancers had insertion or deletion nucleotide position (np) 303–309 mononucleotide repeat region. One carried tandem...
Study Design Comparative Analysis. Objectives The American College of Surgeons developed the 2022 Best Practice Guidelines to provide evidence-based recommendations for managing spinal injuries. This study aims assess concordance ChatGPT-4o and Gemini Advanced with ACS Guidelines, offering first expert evaluation these models in cord Methods Trauma Quality Program Practices Spine Injury were used create 52 questions based on key clinical recommendations. These grouped into informational (8),...
Tumors are influenced by a microenvironment rich in inflammatory cytokines, growth factors and chemokines, which may promote tumor growth. Interleukin-6 (IL-6) is multifunctional cytokine known as regulator of immune inflammation responses. IL-6 has also been reported to be associated with progression chemoresistance different types cancers. In our study, we demonstrated that enriches the properties lung cancer stem-like cells A549 cultured spheroid medium. promotes sphere formation...
Abstract Background and Objectives In metastatic colorectal cancer, v‐Ki‐ras2 Kirsten rat sarcoma viral oncogene homolog ( KRAS ) is a predictive biomarker for anti‐epidermal growth factor receptor (EGFR) treatment V‐raf murine B1 BRAF prognostic biomarker. We aimed to determine the impact of mutation as determined from liver metastases specimens on overall survival (OS) in patients following metastasectomy. Methods Liver (n = 292) obtained after metastasectomy were used KRAS/BRAF genotype....
With the progression of molecular techniques, detection circulating plasma DNA (cpDNA) is clinically feasible. However, role cpDNA levels in gastric cancer not well understood. This study assessed mutational profile primary tumors and clarified clinical utility quantitative qualitative alterations 277 patients with advanced cancer. The concentrations were measured by TaqMan qPCR, 68 mutations 8 genes studied for mutations. median stages I, II, III 3979, 3390 4278 copies/mL, respectively,...
Abstract Chemotherapy is generally considered as the main treatment for metastatic gastric adenocarcinoma. The role of gastrectomy cancer without obvious symptoms controversial. objective this study to investigate survival outcomes modalities using a real-world data setting. A retrospective cohort was designed Taiwan Cancer Registry database. We identified and used Kaplan–Meier estimates Cox regressions compare patient outcomes. From 2008 2015, 5599 adenocarcinoma patients were diagnosed...
Gastric cancer is a common worldwide, particularly in East Asia. Chemotherapy used adjuvant or palliative therapies for gastric cancer. However, subsequent chemoresistance often develops. Growth differentiation factor 15 (GDF15) links to several cancers, but its effect on remains unclear. Here, we analyzed clinical samples from genetic databases and included patients with We dissected the regulatory mechanism underlying GDF15-mediated resistance of cisplatin human cells. showed that GDF15...
Abstract Because chromosomal instability (CIN) and microsatellite (MSI) are important genetic alterations in colorectal cancers, we classified the sporadic cancers (CRC) on status of CIN MSI explored their molecular profiles. A total 213 tumors were collected for analysis DNA ploidy, MSI, loss heterozygosity (LOH), mutation p53 (exons 5 to 9), Ki‐ras 1 2) BRAF (V599E). Relationships between clinicopathological variables analyses analyzed with χ 2 test (Yates' correction). Kaplan–Meier...
Gastric adenosquamous carcinoma (GASC) is a rare subtype of gastric cancer. Research on GASC treatment limited, and its outcome usually poor. We investigated the clinical features, immunoprofile GASC, determined optimal modality for these patients.Patients with from Taipei Veterans General Hospital were retrospectively reviewed. Clinical features outcomes evaluated. Adequate samples examined surrogate biomarkers immunotherapy by IHC staining.Total 14 (0.35%) patients found among 4034 cancer...
Gastric carcinoma is one of the most common and mortal types malignancy worldwide. To date, mechanisms controlling its aggressiveness are not yet fully understood. Notch signal pathway can function as either an oncogene or a tumor suppressor in tumorigenesis. Four members (Notch1-4) receptors were found mammals each exhibits distinct roles progression. Previous study showed that activated Notch1 receptor promoted gastric cancer progression through cyclooxygenase-2 (COX-2). This addressed...
Immunotherapy benefits selected cases of gastric cancer (GC), but the correlation between biomarkers and prognosis is still unclear. Fifty-two patients with GC who underwent immunotherapy were enrolled from June 2016 to December 2020. Their clinical features biomarkers-microsatellite instability-high (MSI-H), programmed cell death ligand 1 (PD-L1) combined positive score (CPS), Epstein-Barr encoding region (EBER)-were analyzed. Eight had MSI-H, five EBER, 29 CPS ≥ 1, 20 no biomarker. The...
A comprehensive study of carcinoid tumors from United States-based databases indicated that the small intestine, colon, rectum, and bronchopulmonary system are common locations for tumors. In addition, certain tumors, such as rectal carcinoids, appeared to be overrepresented in nonwhite populations States. High frequencies associated noncarcinoid malignancies were reported some articles. The objective current was address organ distribution, frequency metastasis, survival rates Taiwanese,...
Cancer stem cells (CSCs), a subpopulation of cancer responsible for tumor initiation and treatment failure, are more susceptible to ferroptosis-inducing agents than bulk cells. However, regulatory pathways controlling ferroptosis, which can selectively induce CSC death, not fully understood. Here, we demonstrate that the CSCs esophageal squamous carcinoma enriched by spheroid culture have increased intracellular iron levels lipid peroxidation, thereby increasing exposure several products...
In recent decades, research concerning gastric carcinogenesis has rapidly progressed. It is evident that hepatocyte growth factor (HGF) clinically related to cancer progression and metastasis. addition, previous studies have found expression of Notch ligand Jagged1 correlated with the poor prognosis cancer. However, interaction between HGF/c-Met Notch1 signaling pathways remains unknown. present study, we patients positive c-Met exhibited poorer overall survival than without (P=0.043) was...
Background: Although particular matter (PM) increases incidence and severity of idiopathic pulmonary fibrosis, the underlying mechanism remains elusive. Methods: The effects PM were evaluated in a murine model bleomycin-induced fibrosis. Mice divided into four groups, receiving: (1) Saline (control), (2) bleomycin, (3) PM, or (4) bleomycin plus (Bleo+PM). Additional groups Bleo+PM mice treated with sivelestat (an inhibitor neutrophil elastase) reparixin (a C-X-C motif chemokine receptor 2...
Addition of oxaliplatin to adjuvant 5-FU has significantly improved the disease-free survival and served as first line chemotherapy in advanced colorectal cancer (CRC) patients. However, a fraction patients remains refractory oxaliplatin-based treatment. It is urgent establish preclinical platform predict responsiveness toward CRC well improve efficacy resistant patients.A living biobank organoid lines were established from Oxaliplatin sensitivity was assessed patient-derived tumor organoids...
Abstract Anti‐cancer activities of resveratrol (3,4′,5‐trihydroxylstilbene) have attracted extensive research attention. Suppression pulmonary metastasis BALB/c mice challenged with CT26 colorectal adenocarcinoma cells achieved by oral administration was assessed in three separate experiments. Each mouse tail vein injection cells. Prior to challenge, 8‐wk‐old were fed a basal diet and orally administered (30 mg/kg/2 days) eight or twelve times. After continued until sacrificed on day 20. As...