A5100733708- Bioinformatics and Genomic Networks
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Gene Regulatory Network Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Gut microbiota and health
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Tracheal and airway disorders
- Radiomics and Machine Learning in Medical Imaging
- Organ Transplantation Techniques and Outcomes
- Lung Cancer Diagnosis and Treatment
- Microbial Metabolic Engineering and Bioproduction
- Renal Transplantation Outcomes and Treatments
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Immune Cell Function and Interaction
- Gene expression and cancer classification
- Viral Infections and Vectors
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- T-cell and B-cell Immunology
- Antifungal resistance and susceptibility
- Hepatitis C virus research
National Yang Ming Chiao Tung University
2015-2025
Nantong University
2025
Tianjin Third Central Hospital
2022-2025
Tianjin Medical University
2022-2025
Nankai University
2022-2025
Center for Disease Control
2024-2025
Changshu No.1 People's Hospital
2025
Chang Gung University
2011-2024
Xi'an Botanical Garden of Shaanxi Province
2022-2024
Institute of Botany
2024
Abstract Background Mitochondrial genomes provide a rich source of molecular variation proven and widespread utility in ecology, population genetics evolutionary biology. The tapeworm genus Taenia includes diversity parasites significant human veterinary importance. Here we add complete sequences the mt T. multiceps , hydatigena pisiformis to data set 4 published mtDNAs same genus. Seven species are used compare contrast within between genus, estimate phylogeny for develop novel markers as...
Background: Glioblastoma (GBM) is the most prevalent malignant brain tumor, significantly impacting physical and mental wellbeing of patients. Several studies have demonstrated a close association between gut microbiota development GBM. In this investigation, Mendelian randomization (MR) was employed to rigorously evaluate potential causal relationship Methods: We utilized summary statistics derived from genome-wide (GWAS) encompassing 211 The GBM scrutinized using Inverse Variance Weighted...
Background Cholangiocarcinoma is a challenging malignancy with limited responses to conventional therapies, particularly immune checkpoint inhibitor therapy. Tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) are key components of the tumor microenvironment (TME) have been implicated in response cancer. However, role difference TLSs TILs patients cholangiocarcinoma remains unclear. This study elucidates their contributions TME. Methods We examined 16 samples from...
Lung cancer is the leading cause of deaths worldwide. Many studies have investigated carcinogenic process and identified biomarkers for signature classification. However, based on research dedicated to this field, there no highly sensitive network-based method carcinogenesis characterization diagnosis from systems perspective.In study, a biology approach integrating microarray gene expression profiles protein-protein interaction information was proposed develop biomarker molecular...
The determination of the mutation load, a total number nonsynonymous point mutations, by whole-exome sequencing was shown to be useful in predicting treatment responses cancer immunotherapy. However, this technique is expensive and time-consuming, which hampers its application clinical practice. Therefore, objective study construct load estimation model for lung adenocarcinoma, using small set genes, as predictor immunotherapy response. Using somatic data downloaded from Cancer Genome Atlas...
Abstract The association of dietary inflammatory index (DII) with constipation has not been well studied in general population. Therefore, the aim this cross‐sectional study was to investigate whether DII is associated a large representative sample US Data were obtained from 2005–2010 National Health and Nutrition Examination Survey (NHANES). A total 12,308 participants aged ≥20 years included analysis. calculated based on single 24‐h recall, defined as having fewer than three bowel...
Abstract Background Noise has many important roles in cellular genetic regulatory functions at the nanomolar scale. At present, no good theory exists for identifying all possible mechanisms of networks to attenuate molecular noise achieve ability or amplify randomize outcomes advantage diversity. Therefore, filtering network is an topic gene under intrinsic fluctuation and extrinsic noise. Results Based on stochastic dynamic regulation equation, reaction rates modeled as a state-dependent...
Abstract Background and Objectives Gastric adenocarcinoma (GC) occurs frequently in the sixth decade of life is uncommon patients aged 40 years or younger. The aims this study were to define clinicopathological features elucidate prognostic factors GC young. Methods Between 1998 2006, 1,815 undergoing resection enrolled a prospective database. findings for 115 (6.0%) younger compared with those 1,009 between 56 75 old. Results group young included significantly more women than old (60.0% vs....
With the accumulation of increasing omics data, a key goal systems biology is to construct networks at different cellular levels investigate machinery cell. However, there currently no satisfactory method an integrated network that combines gene regulatory and signaling pathway. In this study, we kinds data developed systematic based on coupling dynamic models statistical assessments. The proposed was applied S. cerevisiae stress responses, elucidating response mechanism yeast. From...
Crocetin, an agent derived from saffron, has multiple pharmacological properties, such as neuroprotective, anti-oxidant, and anti-inflammatory actions. These properties might benefit the treatment of Alzheimer's disease (AD). In present study, we tested whether crocetin attenuates inflammation amyloid-β (Aβ) accumulation in APPsw transgenic mice, AD mouse models. Cell viability levels Aβ40 Aβ42 HeLa cells stably transfected with Swedish mutant APP751 were evaluated. Mice transgene used...
Background Immunological checkpoint blockade is effective in treating various malignancies. Identifying predictive biomarkers to assist patient selection for immunotherapy has become a priority both clinical and research settings. Methods Mutations patients who responded were identified through next-generation sequencing. Relationships among protein kinase, DNA-activated, catalytic polypeptide ( PRKDC ) mutations, mutation load microsatellite instability (MSI) analyzed using datasets from...
Background: Atherosclerosis can impact cancer progression due to the cholesterol and calcium metabolism, illustrating links between atherosclerosis metastasis. Tetraspanin 4 (TSPAN4) may help understand migrasomes in diseases provide novel targets for treatment. Methods: TSPAN4 expression Gene Expression Omnibus (EO) dataset multiple omics data were explored, such as enriched pathways analysis, protein-protein interaction immune subtypes well diagnostic prognostic value pan-cancer. The...
Liver cancer is the fourth most deadly and early detection timely treatment apparently play a crucial role in it. Intestinal bacteria affect development of liver through various pathways. In this study, gut patients analyzed detail by using macro-genome sequencing technology, some bacterial species metabolic pathways that may have been identified, addition, factors tumor size other important clinical indicators also which provides scientific basis for research related to new insights cancer.
The mortality of patients with acute myocardial infarction (MI) raised rapidly in last decade and obesity are becoming the major cause to CAD progression, thus inducing heart failure preserved ejection fraction (HFpEF). However, why visceral adipocytes show different effects on healthy ageing cardiomyocytes is less known. GSE251971 was downloaded Venn diagram between adipocyte genes DEGs performed obtain adipocyte-associated failure. Protein-protein interaction (PPI) network constructed hub...
Gastrointestinal (GI) cancers account for more than one-third of cancer-related mortality, and the prognosis late-stage patients remains poor. Immunotherapy has been proven to extend survival at advanced stages; however, challenges persist in patient selection overcoming drug resistance. Tumor-infiltrating lymphocytes (TILs) tertiary lymphoid structures (TLS) tumor microenvironment (TME) have found be associated with anti-tumor immune responses. 'Hot tumors' high levels infiltration tend...
High-speed aircraft experiences severe aerodynamic heating at high Mach numbers, requiring accurate prediction of aerothermal effects before designing thermal protection systems. With the rise artificial intelligence and potential neural networks, data-driven methods for have gained significant attention. This study focuses on numerical simulations phenomena explores machine learning applications in heat prediction. First, a two-dimensional cylinder case was simulated using finite volume...
<title>Abstract</title> MiR-195-5p has been confirmed to be intimately linked many cancers development, whereas its role in gastric cancer (GC) remains controversial. The objective of this study was explore the potential function and mechanism miR-195-5p GC. First, level GC analyzed based on qRT-PCR TCGA STAD. Then, cells detected via CCK-8, clone formation assay, flow cytometry, transwell, wound healing assay. Subsequently, we explored possible using KEGG analysis, database Western blot,...
Motivation: The robustness of a biochemical network is defined as the tolerance variations in kinetic parameters with respect to maintenance steady state. Robustness also plays an important role fail-safe mechanism evolutionary process networks. purposes this paper are use synergism and saturation system (S-system) representation describe develop measure subject parameters. Since most networks nature operate close state, we consider only measurement at
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Molecular noises in gene networks come from intrinsic fluctuations, transmitted noise upstream genes, and the global affecting all genes. Knowledge of molecular filtering is crucial to understand signal processing design noise-tolerant circuits for synthetic biology. A nonlinear stochastic dynamic model proposed describing a network under fluctuations extrinsic noises. The...
Differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) from its histologic mimickers, especially metastatic adenocarcinomas gastric and pancreatic origin, is a great challenge for pathologists. In this study, through bioinformatics analysis data The Cancer Genome Atlas Gene Expression Omnibus, we identified C-reactive protein (CRP) as candidate marker to differentiate iCCA other validated diagnostic performance by immunohistochemistry in large cohort clinical samples including 103...
Abstract Background Neutrophil‐lymphocyte ratio ( NLR ) represents a pro‐tumor inflammatory environment and host immunity. The aim of this study was to examine the effect subsequent for hepatocellular carcinoma (HCC) after liver resection. Methods A total 672 patients had resection HCC were included in study. at diagnosis recurrence collected. 2.5 used as cut‐off value calculate its prognostic effect. Results According value, with >2.5 larger tumor size, higher histology grade, rates...