A5005330403- Advanced Breast Cancer Therapies
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- DNA Repair Mechanisms
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Neuroendocrine Tumor Research Advances
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- PARP inhibition in cancer therapy
- Hippo pathway signaling and YAP/TAZ
- Cancer Treatment and Pharmacology
- Ubiquitin and proteasome pathways
- Chronic Lymphocytic Leukemia Research
- BRCA gene mutations in cancer
- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Genomics and Chromatin Dynamics
- Exercise and Physiological Responses
- PI3K/AKT/mTOR signaling in cancer
- Ferroptosis and cancer prognosis
- Neuroblastoma Research and Treatments
Taipei Veterans General Hospital
2010-2025
National Yang Ming Chiao Tung University
2015-2025
Kaohsiung Veterans General Hospital
2023
National Yang Ming University Hospital
2009-2019
La Jolla Institute For Molecular Medicine
2018
Scripps Research Institute
2017-2018
Indiana University School of Medicine
2018
Fujian Medical University
2018
National Taipei University
2009-2017
Taipei Medical University Hospital
2016
Introduction. Acute pancreatitis (AP) is a common illness with varied mortality and morbidity. Patients AP complicated acute renal failure (ARF) have higher than patients alone. Although ARF has been proposed as leading cause for admitted to the ICU, few studies directly analyzed relationship between ARF. Methods. We performed retrospective study using population-based database from Taiwan National Health Insurance Research Database (NHIRD). In period 1 January 2005 31 December 2005, every...
Background Immunological checkpoint blockade is effective in treating various malignancies. Identifying predictive biomarkers to assist patient selection for immunotherapy has become a priority both clinical and research settings. Methods Mutations patients who responded were identified through next-generation sequencing. Relationships among protein kinase, DNA-activated, catalytic polypeptide ( PRKDC ) mutations, mutation load microsatellite instability (MSI) analyzed using datasets from...
While mutations in the PIK3CA gene play important roles human breast carcinogenesis, PIK3R1 alterations are recognized as actionable for clinical cancer treatment. We aimed to elucidate role of cell proliferation on carcinoma and correlate expression with patients' outcome using tumor tissue arrays. Using BT-474 (estrogen receptor (ER)+/human epidermal growth factor 2 (HER2)-high) line vitro model, was elucidated by knock-down (ΔPIK3R1) this line. Between January 2000 December 2015, records...
Background: Neuroendocrine prostate cancer (NEPC) (de novo or treatment related [t-NEPC]) is a rare and deadly variant of cancer. While de NEPC rare, t-NEPC occurs more frequently in patients with castration-refractory Owing to the rarity NEPC, no standard has been established, outcomes are generally unsatisfactory. Methods: This study retrospectively reviewed cases at Taipei Veterans General Hospital between 2018 2023. Clinical outcomes, modalities, genomic profiles were recorded. We also...
Introduction: Despite rapidly improving therapeutics, challenges remain in the treatment of advanced breast cancer. Vinorelbine, a semisynthetic vinca alkaloid, is effective and well-tolerated cancer treatment. The combination vinorelbine platinum-combination but underreported chemotherapy regimen. Bevacizumab, VEGF-neutralizing antibody, has shown efficacy HER2-negative metastatic (mBC) when combined with chemotherapy. In this study we aimed to investigate clinical molecular effects...
Objectives This study aimed to assess preferences of patients and doctors regarding treatment attributes for early-stage triple-negative breast cancer (eTNBC) in the Asia–Pacific region. Design A discrete choice experiment (DCE) by cross-sectional survey was conducted with doctors. Key relevant eTNBC decision-making were verified through a consultative process clinical experts. The levels description seven refined cognitive interviews. D-efficient fractional-factorial design employed create...
Abstract Background Neuroendocrine carcinoma (NEC) is an aggressive, poorly differentiated Grade 3 (G3) tumor with high nuclear and cellular atypia Ki-67 indices over 20%. While most cases are lung NECs, extrapulmonary NECs rarer less studied. Standard treatment involves etoposide platinum (EP) chemotherapy. Inspired by the IMpower133 study, which showed survival benefits atezolizumab plus chemotherapy in extensive-stage small-cell cancer, this study investigates whether combined can offer...
The binary classification of human epidermal growth factor receptor 2 (HER2) as HER2-positive [immunohistochemistry (IHC) 2+/in situ hybridization (ISH)+ or 3+] HER2-negative (IHC 0, 1+, 2+/ISH-) has been reassessed due to the efficacy an anti-HER2 antibody-drug conjugate-Trastuzumab Deruxtecan in HER2-low 1+ unresectable/metastatic breast cancer (mBC) patients. However, little is known about prevalence and outcomes mBC Taiwan. This retrospective study rescored archived HER2 IHC slides...
Lung cancer is typically categorized into small cell lung (SCLC) and non-small (NSCLC). NSCLC comprises of the majority with a poor prognosis in advanced cases. Transcriptional profiling studies, including microarrays RNA-sequencing have significantly enriched our knowledge gene expression patterns NSCLC. A recent transcriptional study identified high prevalence CBX3/HP1-gamma upregulation human samples. an isoform heterochromatin protein 1 family, which plays role formation linked to...
Hip fracture is an important health care issue in the elderly. Postoperative pulmonary complications occur 4% of patients after hip surgery. However, previous research limited regarding rehabilitation this group. In study, we present clinical evidence impact a comprehensive program elderly We designed nonrandomized, Quasi-experimental comparing 2 sequential time periods same center. Elderly (≥65 years) with new from February 1, 2014 to December 31, 2015 and who were willing undergo...
Abstract Purpose Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy have demonstrated significant clinical benefits in progression-free and overall survival. This study investigates the outcomes associated two kinds of CDK4/6i patients hormone receptor (HR)-positive metastatic relapsed breast cancer to inform real-world evidence treatment strategies. Methods retrospective included 340 Taiwanese HR-positive advanced from Taipei Veterans General Hospital, between...
Sports anemia is a widely observed phenomenon after prolonged running. There are various factors that contribute to sports anemia, including hemodilution, exercise-induced oxidative stress, iron deficiency, gastrointestinal bleeding, hematuria, and hemolysis resulting from foot-strike and/or compression of contracting muscles on capillaries. Until now, there has been no published report describes the overall hematological, urinary, fecal consequences in Asian male ultramarathoners 100-km...
Friedreich ataxia (FRDA) is a neurodegenerative disorder caused by transcriptional silencing of the frataxin (FXN) gene, resulting in loss essential mitochondrial protein frataxin. Based on knowledge that GAA·TTC repeat expansion first intron FXN induces heterochromatin, we previously showed 2-aminobenzamide-type histone deacetylase inhibitors (HDACi) increase mRNA levels induced pluripotent stem cell (iPSC)-derived FRDA neurons and circulating lymphocytes from patients after HDACi oral...
The aim of this study was to elucidate molecular profiling in HER2-low tumors based on a promising dataset. A total 615 consecutive HER2-negative breast cancer samples were assayed. genomic mutations the two groups with different HER2 expression levels (HER2-0 vs. HER2-low) compared. mutation types obtained via next-generation targeted sequencing correlated clinicopathological features patients HER2-0 and cancer. results showed that there significantly higher percentage receptor-positive...
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy (ET) are the standard first-line treatment for hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC); however, disease progression occurs in almost all patients and additional options needed. Herein we report outcomes of postMONARCH trial investigating a switch ET with/without CDK4/6 inhibition abemaciclib after on CDK4/6i.
Abstract Background CDK4/6 inhibitors (CDK4/6i) have shown great efficacy in prolonging progression-free survival and is the current standard of care for hormone positive (HR(+)) metastatic breast cancer (mBC). Despite well tolerability ease use, most common side effect CDK4/6i myelosuppression, with neutropenia prevalent adverse effect. Studies show that prevalence severity are more marked Asian patients, although details remain obscure. Methods In this study, we retrospectively analyzed...
Xeroderma pigmentosum group D (XPD) participates in DNA unwinding during nucleotide excision repair, which may alter the efficacy of platinum‐based chemotherapy. We analyzed influence codon 751 Lys→Gln polymorphism XPD on its protein expression levels, clinico‐pathological features, and outcome 188 Chinese patients with metastatic colorectal carcinoma (CRC) that had been treated first‐line Oxaliplatin + Leucovorin 5‐Fluorouracil (FOLFOX‐4) The results showed comparison Caucasian populations,...
Epidermal growth factor receptor- tyrosine kinase inhibitors (EGFR-TKI) are recommended first-line therapy for advanced non-small cell lung cancer (NSCLC) with sensitizing EGFR mutations. It is of clinical interest to identify concurrent genetic mutations in NSCLC patients the hopes discovering predictive biomarkers towards EGFR-TKI treatment. We retrospectively analyzed a cohort mutant who underwent treatment first generation TKIs at our hospital by multi-gene panel via next sequencing. A...