A5031663953- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Vascular Tumors and Angiosarcomas
- Multiple Myeloma Research and Treatments
- Cancer Mechanisms and Therapy
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Gallbladder and Bile Duct Disorders
- CAR-T cell therapy research
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Hepatitis B Virus Studies
- Ferroptosis and cancer prognosis
- Multiple and Secondary Primary Cancers
- Metastasis and carcinoma case studies
- Cancer, Lipids, and Metabolism
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
- Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
Taipei Veterans General Hospital
2016-2025
National Yang Ming Chiao Tung University
2015-2025
ORCID
2024
University College London
2023
Faculty (United Kingdom)
2018-2023
Chang Gung Memorial Hospital
2020
National Yang Ming University Hospital
2016-2018
Institute of Clinical Research
2018
National Taiwan University Hospital
2015
Far Eastern Memorial Hospital
2015
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality in Taiwan. The Taiwan Liver Cancer Association and the Gastroenterological Society had established management consensus guideline 2016. current recommendations focus on updating critical issues regarding HCC, including surveillance, diagnosis, systemic treatment. For updated suggests role dynamic computed tomography or magnetic resonance imaging contrast-enhanced ultrasound (CEUS) selected patients. this update...
Immune checkpoint inhibitors (ICIs) with nivolumab and pembrolizumab are promising agents for advanced hepatocellular carcinoma (HCC) but lack of effective biomarkers. We aimed to investigate the potential predictors response factors associated overall survival (OS) ICI treatment in unresectable HCC patients. Ninety-five patients who received or were enrolled analyses. Radiologic evaluation was based on RECIST v1.1. Factors outcomes analyzed. Of 90 evaluable images, objective rate (ORR)...
Background:Radioactive iodine (RAI) is widely used for the treatment of thyroid cancers. However, information on associations between RAI dose and second primary malignancy (SPM) lacking.
Abstract In our previous phase II T1219 trial for advanced biliary tract cancer (ABTC), the combination of nivolumab with modified gemcitabine and S-1 exhibited promising efficacy, while programmed-death-ligand-1 (PD-L1) expression did not predict chemoimmunotherapy efficacy. Lymphocyte-activation-gene-3 (LAG-3), a negative immune checkpoint, is frequently co-expressed PD-L1. This study assessed predictive value LAG-3 in ABTC patients who received chemoimmunotherapy. We analyzed 44...
Background To evaluate the risk and sites of metachronous secondary primary malignancies (SPMs) among patients with esophageal cancer. Methods Newly diagnosed cancer between 1997 2011 were recruited. avoid surveillance bias, SPMs that developed within one year excluded. Standardized incidence ratios (SIRs) in these calculated by comparing to general population. Risk factors for SPM development, included age, sex, comorbidities cancer-related treatments, estimated Cox proportional hazards...
Lenvatinib, a multi-tyrosine kinase inhibitor that inhibits vascular endothelial growth factor and fibroblast receptors pathway, activated the immune response in tumor microenvironment. However, combination of lenvatinib anti-PD-1 has been reported early phase studies. Hence, this study aims to explore efficacy toxicity combined with nivolumab real-world setting. Advanced HCC patients who underwent (L + N group) treatment at Taipei Veterans General Hospital (Taipei, Taiwan) were reviewed...
Abstract Background Caffeine consumption has been reported to decrease bone mineral density (BMD), increase the risk of hip fracture, and negatively influence calcium retention. In this study, we investigated caffeine on osteoblasts behaviour. Method Osteoblasts derived from newborn Wistar-rat calvaria was used in study. The effects various concentrations cell activities were evaluated by using MTT assay. Alkaline phosphatase (ALP) staining, von Kossa staining biochemical parameters...
This study evaluated the risk of cancer among patients with iron deficiency anemia (IDA) by using a nationwide population-based data set.Patients newly diagnosed IDA and without antecedent between 2000 2010 were recruited from Taiwan National Health Insurance Research Database. The standardized incidence ratios (SIRs) types calculated.Patients exhibited an increased overall (SIR: 2.15). Subgroup analysis showed that both sexes in all age groups had SIR. After we excluded within first 5 years...
600 Background: Immunotherapy combinations such as atezolizumab plus bevacizumab (Atezo-Bev) or STRIDE have been established standard therapies for patients with advanced hepatocellular carcinoma (HCC). After dual immunotherapy treatment, durable responders and long-term survivors had reported. However, the longevity of outcomes following Atezo-Bev treatment remains to be evaluated. Methods: We analyzed medical records four centers in Taiwan Child-Pugh class A liver reserve who received...
Alpha-fetoprotein (AFP) is a key biomarker for hepatocellular carcinoma (HCC), but 30–40% of cases are AFP-negative. Prothrombin induced by vitamin K absence II (PIVKA-II) more sensitive HCC detection, though its role in systemic therapy remains underexplored. This study aimed to evaluate PIVKA-II non-AFP-secreting treated with therapy. Patients unresectable undergoing were enrolled. Baseline imaging and levels recorded. After 8–12 weeks treatment, response was evaluated through repeat...
Abstract Background Neuroendocrine carcinoma (NEC) is an aggressive, poorly differentiated Grade 3 (G3) tumor with high nuclear and cellular atypia Ki-67 indices over 20%. While most cases are lung NECs, extrapulmonary NECs rarer less studied. Standard treatment involves etoposide platinum (EP) chemotherapy. Inspired by the IMpower133 study, which showed survival benefits atezolizumab plus chemotherapy in extensive-stage small-cell cancer, this study investigates whether combined can offer...
Background Studies have suggested that chronic inflammation plays an essential role in the pathophysiology of both rheumatoid arthritis (RA) and bipolar disorder. The most common clinical features associated with RA are anxiety depression. risk disorder among patients has not been characterized adequately. Objective To determine association between subsequent development examine factors for RA. Methods We identified who were diagnosed Taiwan National Health Insurance Research Database. A...
Sorafenib is a small molecule that blocks tumor proliferation by targeting the activity of multi-kinases for treatment advanced hepatocellular carcinoma (HCC). Increasing sorafenib resistance following long-term frequently encountered. Mechanisms underlying remain not completely clear. To further understand mechanism in HCC, we established sorafenib-resistant cell lines slowly increasing concentration culture medium. Upregulation USP22 and ABCC1 were found Sorafenib-resistant cells. cells...
Vascular endothelial growth factor (VEGF) plays a role in the tumor microenvironment. Sorafenib, which inhibits VEGF pathway, has an immune-modulation function but lacks substantial clinical data. This study aims to explore efficacy of anti-PD-1 combined sorafenib advanced hepatocellular carcinoma (HCC).HCC patients who underwent treatment at Taipei Veterans General Hospital (Taipei, Taiwan) between January 2016 and February 2019 were reviewed. The was compared groups after propensity-score...
Female breast cancer patients have an increased risk of developing subsequent malignant diseases, but this issue is rarely discussed in regards to male patients. Thus, we conducted a national survey that included 100,915 female and 578 investigate the second primary malignancy (SPM). During follow-up period 529,782 person-years, 3,153 cases SPM developed. Compared with general population, standardized incidence ratio (SIR) was 1.51 [95% confidence interval (CI): 1.46–1.56]. The observed...
Introduction: Atezolizumab plus bevacizumab is a commonly used first-line regimen for advanced hepatocellular carcinoma (HCC) treatment owing to its superior outcomes compared sorafenib. However, optimal subsequent options patients with HCC who progressed on atezolizumab remain unclear. Methods: This multinational, multi-institutional, retrospective study included from 22 centers in five Asia-Pacific countries were treated bevacizumab, which was discontinued any reason. The endpoints...
Improvements in therapeutic modalities have prolonged the survival of gastric cancer patients. Comorbidities such as thromboembolic events that emerge a result disease complexities and/or treatments received not been considered. The objectives this study are to examine relationship between and ischemic stroke, determine predictive risk factors. A nationwide population-based cohort was conducted using data from Taiwan National Health Insurance database. total 45,060 patients non-cancer...
Abstract Purpose: Modified gemcitabine and S-1 (GS) is an active regimen for patients with advanced biliary tract cancer (ABTC) in our previous study. Herein, we report the results of a single-arm phase II nivolumab plus modified GS (NGS) as first-line treatment ABTC. Patients Methods: received 240 mg 800 mg/m2 on day 1 daily 80/100/120 (based body surface area) days to 10, 2-week cycle. The primary endpoint was objective response rate (ORR). correlation between therapeutic efficacy genetic...
PD-L1 expression is critical in helping tumor cells evade the immune system. However, level of non-oropharyngeal head and neck squamous cell carcinoma (non-OPHNSCC) its association with patient prognosis remains unclear. A retrospective clinicopathological analysis was performed on 106 patients non-OPHNSCC diagnosed between 2007 2014. In current study, tissue arrays from paraffin-embedded samples obtained were constructed, p16INK4A determined using immunohistochemistry. Systemic inflammatory...
<h3>Background</h3> Use of anti-programmed cell death-1 (anti-PD-1) has been successful in treating many types cancers. Despite its promising efficacy, immune-related adverse events are still a major concern. Immune-related cardiotoxicity, which is rare but fatal, recently become focus attention. Cardiotoxicities including myocarditis, cardiomyopathy, cardiac fibrosis, heart block and arrest have reported. Of these toxicities, myocarditis often accompanied by dysrhythmia. The presentation...