A5085286927- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Diverse Approaches in Healthcare and Education Studies
- Fire dynamics and safety research
- VLSI and Analog Circuit Testing
- Integrated Circuits and Semiconductor Failure Analysis
- Physical Education and Pedagogy
- Education, Safety, and Science Studies
- Peptidase Inhibition and Analysis
- Spondyloarthritis Studies and Treatments
- Gout, Hyperuricemia, Uric Acid
- Cancer Treatment and Pharmacology
- Pelvic and Acetabular Injuries
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Bladder and Urothelial Cancer Treatments
- Electric Power System Optimization
- Optimal Power Flow Distribution
- Brain Metastases and Treatment
- Nail Diseases and Treatments
Chungbuk National University Hospital
2018-2025
Samsung Medical Center
2006-2022
Hanyang University
2012-2022
Sungkyunkwan University
2009-2022
National Research Institute of Fire and Disaster
2020
Ministry of Public Safety and Security
2019
Chungbuk National University
2018
Andong National University
2017
Daegu Cyber University
2017
Hanyang University Guri Hospital
2011-2014
<b>Background and study aims: </b>Transanal endoscopic microsurgery (TEM) has been shown to be highly effective for early rectal cancer, submucosal dissection (ESD) introduced treat noninvasive colorectal neoplasia. The aim of this was compare the outcomes ESD TEM superficial cancer. <b>Patients methods: </b>We retrospectively analyzed 63 patients with nonpolypoid high grade dysplasia or submucosa-invading cancer who were treated TEM, compared clinical safety between treatment groups....
Background Immune checkpoint inhibitors (ICIs) have shown significant improvements in patients with advanced non–small cell lung cancer (NSCLC). One of the major issues ICIs is determining optimal treatment duration. Methods This multicenter, retrospective study analyzed clinical outcomes NSCLC who completed 2 years ICI therapy or were treated for more than 6 months and then discontinued without disease progression at 11 medical centers Korea between August 2017 December 2020. Results...
HER2 aberrations have been reported as a novel biomarker in HER2-directed therapy or prognostic marker various tumor types. However, advanced biliary tract cancer (BTC), there few studies regarding biomarker. We analyzed 121 BTC patients who had treated with Gemcitabine/Cisplatin (GP) 1st line between November 2019 and April 2021. Next-generation sequencing (NGS), namely, was performed all patients. The TruSight™ Oncology 500 assay from Illumina used for the NGS panel. Among BTC, were...
Background and Objectives: Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is involved in pancreatic cancer progression an attractive therapeutic target for cancer. In this study, we evaluated the efficacy of small-interfering RNA (siRNA) targeting CEACAM6 (siCEACAM6) CEACAM6-suppressive microRNA-29a (miR-29a) a ductal adenocarcinoma xenograft mouse model using pH-low insertion peptide (pHLIP) technology, which targets acidic tumor microenvironment. Materials Methods: The...
Oversized, muscular calves can cause psychological stress in women. Botulinum toxin A has been used the treatment of benign masseteric hypertrophy with correction squared facial appearance. It is believed that botulinum might also be effective reducing enlarged calf muscles.This study was performed to investigate effect medial gastrocnemius muscles volunteers legs.Botulinum 32, 48, or 72 U injected each head muscle six Clinical photography taken and leg circumferences were measured. The...
BACKGROUND The proper treatment of sacral fracture has yet to be standardized. METHODS Seventy-one patients with fractures who were treated from December 2001 January 2009 evaluated. Classification was made depending on the presence a combined injury in spine or pelvic ring, displacement fracture, and location surgical indications case displaced neurologic injury. procedure used either spinopelvic fixation iliac screws percutaneous iliosacral screw fixation. Fracture causes, treatments,...
Abstract This study compared the tumor immune microenvironments (TIMEs) of primary gastric cancer (PGC) and paired metastatic (MGC). CD4 + CD8 T-cell density PD-L1 expression were evaluated by multiplex immunohistochemistry, DNA mismatch repair (MMR) immune-related genes RNA sequencing. Twenty-three patients who underwent surgical treatment for PGC MGC enrolled in this study. T-cell, cell, CK cell densities significantly lower than PGC. positivity using a combined positive score (≥ 1%)...
eXplainable Artificial Intelligence (XAI) is a new trend of machine learning. Machine learning models are used to predict or decide something, and they derive output based on large volume data set. Here, the problem that it hard know why such prediction was derived, especially when using deep models. It makes unreliable in case reliability-critical applications. So, required explain how derived output. application for self-driving cars because mistakes made by computers inside them can lead...
Background: High tumor mutational burden (TMB-H) has been reported as a predictive marker to immunotherapy or prognostic in various types. However, there little study of the role TMB-H advanced biliary tract cancer (BTC). Methods: We analyzed 119 BTC patients who received Gemcitabine/Cisplatin (GP) first-line treatment between November 2019 and April 2021. Next-generation sequencing (NGS), including TMB analysis, routine clinical practice was performed patients. The TruSightTM Oncology 500...
The activity and safety of neoadjuvant nivolumab plus gemcitabine/cisplatin (N+GC) were tested in patients with muscle-invasive bladder urothelial carcinoma (MIBC).In a prospective phase II trial, cT2-T4a N0 MIBC who eligible for cisplatin medically appropriate to undergo radical cystectomy (RC) enrolled. Treatment 3 mg/kg on days 1 15 GC (cisplatin 70 mg/m2 day 1, gemcitabine 1,000 8, 15) was repeated every 28 up or 4 cycles, depending the surgery schedules. primary endpoint pathologic...
There are limited data on the use of glucose transport protein 1 (GLUT-1) expression as a biomarker for predicting lymph node metastasis in patients with colorectal cancer. GLUT-1 and GLUT-3, hexokinase (HK)-II, hypoxia-induced factor (HIF)-1 expressions may be useful biomarkers detecting primary tumors when combined fluorodeoxyglucose (FDG) uptake positron emission tomography/computed tomography (PET/CT).
Purpose Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor with a poor prognosis that poses challenges for diagnosis using traditional tissue-based techniques. DNA methylation alterations have emerged as potential and promising biomarkers PDAC. In this study, we aimed to assess the diagnostic of novel assay based on epigenetic-specific peptide nucleic acid (Epi-sPNA) in both tissue plasma samples detecting Materials methods The study involved 46 patients PDAC who underwent...
Introduction: Atezolizumab plus bevacizumab is a commonly used first-line regimen for advanced hepatocellular carcinoma (HCC) treatment owing to its superior outcomes compared sorafenib. However, optimal subsequent options patients with HCC who progressed on atezolizumab remain unclear. Methods: This multinational, multi-institutional, retrospective study included from 22 centers in five Asia-Pacific countries were treated bevacizumab, which was discontinued any reason. The endpoints...
This paper presents a method for evaluating nodal probabilistic congestion and reliability indices of transmission systems. Quantitative evaluation system is very important because successful operation an electric power in the deregulated electricity market depends on management. The key point that level equal to difference between composite (HLH) generation (HLI). Risk systems are larger than those as include uncertainties capacity limits lines. characteristics effectiveness this...
Homologous recombination deficiency (HRD) is related to tumorigenesis. Currently, the possibility of HRD as a prognostic biomarker immune checkpoint inhibitors unknown. We aimed investigate whether has potential for immunotherapy.The status homologous was assessed with next-generation sequencing (NGS) TruSight™ Oncology 500 assay in 501 patients advanced solid tumor including gastrointestinal (GI), genitourinary (GU), or rare cancer.among patients, observed follows: 74.7% (347/501) patients;...
A new methodology to increase the encoding efficiency of test compression based on linear feedback shift registers (LFSRs) is proposed. The proposed method combines LFSR reseeding and bit fixing. Deterministic patterns tend have a biased probability logic value 1 or 0 at each primary input. If such inputs are fixed with some combinational logic, then amount data be encoded by will considerably reduced. Additionally, in order reduce volume much further, variable degree polynomial employed. In...
Immune checkpoint inhibitor (ICI)-induced rheumatic immune-related adverse events (irAEs) have been infrequently reported, and the treatment of severe or refractory arthritis as irAEs has not established yet.The patient was a 67-year-old man with history well-controlled foot psoriasis who presented polyarthralgia. He had received pembrolizumab for metastatic gastric adenocarcinoma 2 mo previously. Physical examination revealed erythematous swelling in distal interphalangeal joints, left...
Background: Given that peak age of breast cancer (BC) is younger in Asians than Western populations, relatively higher prevalence pregnancy-associated (PABC) has been reported. This study aimed to analyze the characteristics and clinical outcomes PABC Korea. Methods: We defined as BC diagnosed during pregnancy or first postpartum year. compared clinicopathological between patients with non-PABC prospective YBC cohort from Samsung Medical Center. Results: In total, 1492 were initially...
Purpose: Triple-negative breast cancer (TNBC) is well known for its aggressive course and poor prognosis. In this study, we sought to investigate clinical, demographic, pathologic characteristics treatment outcomes of patients with refractory, metastatic TNBC selected by a clinical data warehouse (CDW) approach. Patients methods: Data were extracted from the real-time registry integrated into Analytics Research Window Integrated Knowledge C (DARWIN-C), CDW Samsung Medical Center. Between...
Purpose Hand-foot syndrome (HFS) and hand-foot skin reaction (HFSR) are relatively common toxicities that interfere with the quality of life (QoL) patients cancer. Anti-inflammatory tripeptide cream (ATPC) is a complex formulation anti-inflammatory tripeptides, CD99-agonist Binterin Wnt-antagonist Winhibin. The present study aimed to assess therapeutic effects ATPC in HFS/HFSR associated anticancer drugs.Materials Methods This was single-center, randomized, double-blind, placebo-controlled...
This paper presents a method for constructing composite power system effective load duration curves (CMELDC) at points by Monte Carte method. The concept of (ELDC) in planning is useful and important both HLI HLII. CMELDC can be obtained from convolution integral processing the probability function unsupplied curve each point. an analogy to ELDC HLI. reliability indices (LOLP, EDNS) are evaluated using CMELDC. Differences levels between HLII come considering with uncertainty associated...
Purpose Trastuzumab has markedly improved the survival outcomes of patients with human epidermal growth factor receptor 2 (HER2)–positive breast cancer, and dual blockade HER2 using trastuzumab pertuzumab in combination taxanes (THP) become a standard care for HER2-positive metastatic cancer (MBC) worldwide since CLEOPATRA trial. We assessed THP as first-line treatment Korean MBC real-world setting.Materials Methods Between August 2008 October 2020, we identified 228 who received palliative...
Large-scale fires mainly due to the ignition of thermal insulation materials in ceiling piloti-type structures are becoming frequent. However, fire spread these cases is not well understood. Herein we performed small-scale and real-scale model tests, numerical simulations using a dynamics simulator (FDS). The experimental FDS results were compared elucidate effects on it. Comparison test revealed that extruded polystyrene (XPS) material generated additional sources above upon melting...