A5047850471- Engineering Applied Research
- Diverse Approaches in Healthcare and Education Studies
- Internet of Things and Social Network Interactions
- Food Quality and Safety Studies
- Gastric Cancer Management and Outcomes
- Agriculture, Soil, Plant Science
- Health and Wellbeing Research
- Nutrition, Health and Food Behavior
- Diverse Topics in Contemporary Research
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Education and Learning Interventions
- Innovation in Digital Healthcare Systems
- Consumer Perception and Purchasing Behavior
- Gastrointestinal Tumor Research and Treatment
- Education, Safety, and Science Studies
- Ecology and Conservation Studies
- Korean Urban and Social Studies
- Technology and Data Analysis
- Healthcare and Venom Research
- Nanofabrication and Lithography Techniques
- Colorectal Cancer Treatments and Studies
- Energy and Environmental Systems
- Synthesis and properties of polymers
- Metastasis and carcinoma case studies
Kosin University
2016-2025
Ewha Womans University
2025
Dankook University
2024
Korea University
2024
Ajou University
2024
Youngsan University
2024
Daejeon Woori Hospital
2023
Asan Medical Center
2023
Jeonbuk National University
2023
Hallym University
2017-2023
Metformin has been known to suppress cancer stem cells (CSCs) in some cancers. However, the differential effects of metformin on CSCs and their mechanisms have not reported. Herein, induced pAMPK activation pS6 suppression metformin-sensitive (HT29) cells, but metformin-resistant (SW620) cells. The oxygen consumption rate was higher HT29 than SW620 showed a prominent decrease after treatment In glutamine-depleted medium, low-glucose became sensitive CSC-suppressing effect metformin. A...
Leucyl-tRNA synthetase (LRS) is known to function as leucine sensor in the mammalian target of rapamycin complex 1 (mTORC1) pathway. However, pathophysiological significance its activity not well understood. Here, we demonstrate that for mTORC1 activation LRS can be decoupled from catalytic activity. We identified compounds inhibit leucine-dependent pathway by specifically inhibiting GTPase activating LRS, while affecting For further analysis, selected one compound, BC-LI-0186, which binds...
<b>Background and study aims: </b>Transanal endoscopic microsurgery (TEM) has been shown to be highly effective for early rectal cancer, submucosal dissection (ESD) introduced treat noninvasive colorectal neoplasia. The aim of this was compare the outcomes ESD TEM superficial cancer. <b>Patients methods: </b>We retrospectively analyzed 63 patients with nonpolypoid high grade dysplasia or submucosa-invading cancer who were treated TEM, compared clinical safety between treatment groups....
AIMTo evaluate the prognostic value of neutrophil-tolymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) in patients with colorectal cancer (CRC). METHODSBetween April 1996 December 2010, medical records from a total 1868 CRC were retrospectively reviewed.The values simple inflammatory markers including NLR PLR predicting long-term outcomes these evaluated using Kaplan-Meier curves Cox regression models. RESULTSThe median follow-up duration was 46 mo (interquartile range, 22-73).The...
Trends in successful eradication of Helicobacter pylori using first-line triple therapy, consisting a proton pump inhibitor, amoxicillin, and clarithromycin, have been understudied. We evaluated H. rates at single center over the last 10 years identified risk factors related to failure.
Study Objectives Health care utilization has progressively increased, especially among Medical Aid beneficiaries in South Korea. The classifies into two categories, type 1 and 2, on the basis of being incapable (those under 18 or over 65 years age, disabled) capable working, respectively. a high possibility for health due to coverage level. In Korea, national insurance (NHI) achieved very short time establish entire Korean population. However there remaine number problems be solved....
Abstract Appropriate storage of fecal samples is a critical step for unbiased analysis in human microbiome studies. The purpose this study was to evaluate the stability microbial community up 18 months. Ten healthy volunteers provided at Jeonbuk National University Hospital. Stool were stored under following six conditions: four different temperatures (− 70 °C, − 20 4 and room temperature [20–25 °C]) two collection tubes (OMNIgene-Gut DNA/RNA shield-fecal tubes). gut analyzed with 16S rRNA...
Colon cancer is a significant health concern, and obesity well-established risk factor. However, previous studies have mainly focused on assessing body weight as factor for colon at specific time point. This nationwide cohort study investigated the association between changes, which can fluctuate throughout an individual's lifespan, incidence of using South Korean population database provided by National Health Insurance Service (NHIS). Participants who underwent biennial screenings 2004...
Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms that mainly occur in the stomach and small intestine; those arising esophagus rarer. A 54-year-old woman was referred to our hospital with a one-month history of dysphagia. Esophagogastroduodenoscopy (EGD), performed approximately five months earlier, had not revealed any specific findings. However, an EGD showed presence round, protruding lesion (approximately 40×30 mm size), normal overlying mucosal surface, 35–39 cm...
Recently, increased body weight has been found to be associated with an increasing risk of several cancers, including gastric cancer. The true pathogenic role hyperglycemia in the development cancer remains unclear as and its conditions may work carcinogenic factors. goal this study was clarify factors early evaluate a homeostasis model assessment insulin resistance (HOMA-IR) index, fasting glucose, lipid profile predictors cancer.A total 63 patients between November 2012 March 2013 were...
The purpose of this study is to find out the association between eating breakfast, breakfast patterns, and metabolic syndrome.We used fourth Korean National Health Nutrition Examination Survey from 2007 2009. A total 16,734 subjects were included. Breakfast dietary patterns extracted by factor analysis. Multiple logistic regression was assess relationship consumption, found that consumption itself reduced risk syndrome (odds ratio=0.82, 95% confidence interval=0.69-0.98). We identified two...
Background/Aim We aimed to evaluate the efficacy of sending educational video clips via smartphone mobile messenger (SMM) on enhancing bowel preparation before colonoscopy. Methods This was a prospective, endoscopist-blinded, randomized controlled study. Patients in SMM group received two sent that explained diet and regimen for preparation, whereas those control did not receive any clips. compared quality between groups, which assessed by an endoscopist using Ottawa scale. Results Between...
AIM:To identify whether the forceps estimation is more useful than visual in measurement of colon polyp size. METHODS:We recorded colonoscopy video clips that included scenes visualizing and using open biopsy association with polyp, which were used for an exam.A total 40 endoscopists from Busan Ulsan Gyeongnam Intestinal Study Group Society (BIGS) participated this study.Participants watched pairs Retrospective ORIGINAL ARTICLE CONCLUSION:Application method when measuring size could help...
Primary NK-/T-cell lymphoma of the gastrointestinal tract is a very rare disease with poor prognosis. The aim this study was to determine clinical and endoscopic characteristics patients primary lymphoma.The features 14 findings in 11 these were reviewed. Their median age 42 years (range 23-78) at time diagnosis.The initial presenting symptoms bleeding (n = 6, 42%), abdominal pain 4, 29%), epigastric soreness 29%). an advanced stage diagnosis: II 5 (36%); III 4 (28%); IV (36%). Initial...
The aim of this study was to identify the effect mucosal healing (MH) on clinical relapse in patients with ulcerative colitis (UC) who are remission, special reference Mayo endoscopic subscore 0.Between November 2005 and December 2013, medical records from a total 215 UC underwent colonoscopic examination at time remission were retrospectively reviewed. Endoscopic MH defined as '0 point' (Mayo 0). Patients categorized into two groups according then analyzed.The baseline characteristics both...
Snakebite is an emergency which causes local symptoms such as pain and edema around the bite. Systemic may also develop, dizziness or renal failure, even cause death. The purpose of this research was to assess validity safety snakebite protocol for surgery when treating patients.Retrospective performed on patients who were admitted after being treated at center from January 2008 December 2012. When necessary, debridement performed, 46 111 (41.4%) underwent debridement. Those had received...
Background/Aims Recently, a number of studies have reported that the gut microbiota could contribute to human conditions, including obesity, inflammation, cancer development, and behavior. We hypothesized composition distribution are different according stool frequency, attempted identify association between frequency. Methods collected fecal samples from healthy individuals divided into 3 groups frequency: group 1, small defecation (≤2 times/wk); 2, normal (1 time/day or 1 time/2 day); 3,...
Background Gut microbial dysbiosis contributes to the development and progression of colorectal cancer (CRC). Natural killer (NK) cells are involved in early defense mechanisms kill infective pathogens tumor by releasing chemokines cytokines. To better understand relationship between gut microbiome CRC, it was hypothesized here that a high abundance Fusobacterium nucleatum (F. nucleatum) gastrointestinal tract could cause reduced NK cell activity. Aim identify associations F. levels Methods...
Background and aim High heart rate is an independent predictor of total cancer incidence all-cause mortality in patients with cancer. We aimed to evaluate the impact resting on recurrence colorectal polyp, using long-term surveillance follow-up data survivors. Methods Three hundred were selected from survivor cohort Severance Hospital, Seoul, Korea. Resting rate, physical activity, body composition analysis at time 5-year survival, clinical including colonoscopy results collected for mean...
Current evidence support that the gut microbiota plays a potential role in obesity. Bariatric surgery can reduce excess weight and decrease risk of life-threatening weight-related health problems may also influence microbiota. In this study, we aimed to investigate changes before after bariatric evaluate association microbial shift altered body mass index (BMI) surgery.Between January 2019 July 2020, stools from 58 patients scheduled for were collected. Six months surgery, 22 these...