A5053840410- Muscle Physiology and Disorders
- Nerve injury and regeneration
- Cardiac Arrest and Resuscitation
- Mesenchymal stem cell research
- Trauma and Emergency Care Studies
- Sepsis Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Traumatic Brain Injury and Neurovascular Disturbances
- Emergency and Acute Care Studies
- Neurogenetic and Muscular Disorders Research
- Cardiomyopathy and Myosin Studies
- Lymphoma Diagnosis and Treatment
- Intestinal and Peritoneal Adhesions
- Radiation Dose and Imaging
- Patient Safety and Medication Errors
- Anesthesia and Neurotoxicity Research
- Renal function and acid-base balance
- Diverticular Disease and Complications
- Gastrointestinal motility and disorders
- Metabolomics and Mass Spectrometry Studies
- S100 Proteins and Annexins
- Psidium guajava Extracts and Applications
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal Tumor Research and Treatment
Seoul National University
2003-2024
Seoul National University Bundang Hospital
2007-2013
Samsung Medical Center
2007-2013
Sungkyunkwan University
2007-2013
Seoul National University Hospital
2007-2008
Inje University
2008
Stony Brook University Hospital
2007
Stony Brook University
2007
University of Michigan
2004
The survival of motor neuron (SMN) protein is a major component the pre-mRNA splicing machinery and required for RNA metabolism. Although SMN has been considered fundamental gene central nervous system, due to its relationship with neuromuscular diseases, such as spinal muscular atrophy, recent studies have also revealed requirement in non-neuronal cells peripheral regions. Here, we report that fibro-adipogenic progenitor subpopulation expressing Dpp4 (Dpp4+ FAPs) system. Furthermore, reveal...
Abstract Purpose of Review The purpose this review is to describe the advancements in combat casualty care from prehospital environment, through en route care, and into damage control resuscitative surgical during recent military conflict. We also explore potential areas future research needed enhance survivability on battlefield large-scale operations (LSCO). Recent Findings In space, use tourniquets has become standard practice for controlling severe hemorrhage, while techniques like...
Zolgensma is a gene-replacement therapy that has led to promising treatment for spinal muscular atrophy (SMA). However, clinical trials of have raised two major concerns: insufficient therapeutic effects and adverse events. In recent trial, 30% patients failed achieve motor milestones despite pre-symptomatic treatment. addition, more than 20% showed hepatotoxicity due excessive virus dosage, even after the administration an immunosuppressant. Here, we aimed test whether...
Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal that can contribute to muscle tissue homeostasis and regeneration, as well postnatal maturation lifelong maintenance of the neuromuscular system. Recently, traumatic injury peripheral nerve was shown activate FAPs, suggesting FAPs respond injury. However, questions how sense anatomically distant whether directly regeneration remained unanswered. Here, utilizing single-cell transcriptomics mouse models, we discovered a subset...
Primary NK-/T-cell lymphoma of the gastrointestinal tract is a very rare disease with poor prognosis. The aim this study was to determine clinical and endoscopic characteristics patients primary lymphoma.The features 14 findings in 11 these were reviewed. Their median age 42 years (range 23-78) at time diagnosis.The initial presenting symptoms bleeding (n = 6, 42%), abdominal pain 4, 29%), epigastric soreness 29%). an advanced stage diagnosis: II 5 (36%); III 4 (28%); IV (36%). Initial...
To determine the utility of multidetector computed tomography (MDCT) in patients with clinically evident acute appendicitis and to compare test characteristics overall clinical impression, Alvarado scores, MDCT suspected appendicitis.A prospective observational cohort study was conducted two urban emergency departments (ED). Consecutive were evaluated by an physician who asked whether or not. Elements scores collected all then underwent a decision operate, observe, discharge made surgeon....
During exercise, skeletal muscle is exposed to a low oxygen condition, hypoxia. Under hypoxia, the transcription factor hypoxia-inducible factor-1α (HIF-1α) stabilized and induces expressions of its target genes regulating glycolytic metabolism. Here, using muscle-specific gene ablation mouse model, we show that Brg1/Brm-associated 155 (Baf155), core subunit switch/sucrose non-fermentable (SWI/SNF) complex, essential for HIF-1α signaling in muscle. Muscle-specific Baf155 increases oxidative...
Abstract Age-associated muscle atrophy is a debilitating condition associated with loss of mass and function age that contributes to limitation mobility locomotion. However, the underlying mechanisms how intrinsic changes are largely unknown. Here we report that, age, Mind bomb-1 (Mib1) plays important role in skeletal maintenance via proteasomal degradation-dependent regulation α-actinin 3 (Actn3). The disruption Mib1 myofibers (Mib1 ΔMF ) results alteration type 2 glycolytic myofibers,...
We present 19 cases in which argon plasma coagulation (APC) was used as curative initial treatment for 5 low-grade esophageal squamous intraepithelial neoplasias (ESINs), 12 high-grade ESINs, and 2 early cell carcinomas (ESCCs). Complete response defined the absence of tumor from any biopsy taken ablated lesion. At follow-up endoscopy – 4 months after APC, 94.7 % patients had achieved complete a single session. Only one patient with ESIN showed local recurrence. This underwent additional APC...
Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal that can contribute to muscle tissue homeostasis and regeneration, as well postnatal maturation lifelong maintenance of the neuromuscular system. Recently, traumatic injury peripheral nerve was shown activate FAPs, suggesting FAPs respond injury. However, questions how sense anatomically distant whether directly regeneration remained unanswered. Here, utilizing single-cell transcriptomics mouse models, we discovered a subset...
Little is known about the effects of acute acoustic stress on anorectal function. To determine function and sensation in healthy volunteers. Ten volunteers (7 M, 3 F, mean age 34 +/- years) underwent manometry, testing rectal compliance using a barostat with without noise separate days. Rectal perception was assessed an ascending method limits protocol 5-point Likert scale. Arousal anxiety status were evaluated visual analogue Acoustic significantly increased score (P < 0.05). decreased...
Abstract Background With organismal aging, the hypothalamic–pituitary–gonadal (HPG) activity gradually decreases, resulting in systemic functional declines of target tissues including skeletal muscles. Although HPG axis plays an important role health span, how systemically prevents aging is largely unknown. Methods We generated muscle stem cell (MuSC)‐specific androgen receptor (Ar) and oestrogen 2 (Esr2) double knockout (dKO) mice pharmacologically inhibited (Antide) to mimic decreased...
Abstract Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal that can contribute to muscle tissue homeostasis and regeneration, as well postnatal maturation lifelong maintenance of the neuromuscular system. Recently, traumatic injury peripheral nerve was shown activate FAPs, suggesting FAPs respond injury. However, questions how sense anatomically distant whether directly regeneration remained unanswered. Here, utilizing single-cell transcriptomics mouse models, we discovered...
Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal that can contribute to muscle tissue homeostasis and regeneration, as well postnatal maturation lifelong maintenance of the neuromuscular system. Recently, traumatic injury peripheral nerve was shown activate FAPs, suggesting FAPs respond injury. However, questions how sense anatomically distant whether directly regeneration remained unanswered. Here, utilizing single-cell transcriptomics mouse models, we discovered a subset...
Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal that can contribute to muscle tissue homeostasis and regeneration, as well postnatal maturation lifelong maintenance of the neuromuscular system. Recently, traumatic injury peripheral nerve was shown activate FAPs, suggesting FAPs respond injury. However, questions how sense anatomically distant whether directly regeneration remained unanswered. Here, utilizing single-cell transcriptomics mouse models, we discovered a subset...