A5033106596- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Calcium signaling and nucleotide metabolism
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cardiac Valve Diseases and Treatments
- Lysosomal Storage Disorders Research
- RNA modifications and cancer
- Cardiac and Coronary Surgery Techniques
- Mechanical Circulatory Support Devices
- Pulmonary Hypertension Research and Treatments
- Galectins and Cancer Biology
- Exercise and Physiological Responses
- Cardiac Structural Anomalies and Repair
- Genomics and Chromatin Dynamics
- Cardiac Imaging and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Advanced MRI Techniques and Applications
- Trauma Management and Diagnosis
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Muscle Physiology and Disorders
- Retinal Development and Disorders
The University of Texas Southwestern Medical Center
2025
Children's Medical Center
2025
Innovative Genomics Institute
2022
University of California, Berkeley
2018-2022
Seoul National University
2010-2020
Institute on Aging
2020
Konkuk University
2020
UMass Memorial Health Care
2014
Wonju Severance Christian Hospital
2007
Keio University
2003
Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients, including cholesterol. Through bioinformatic analysis lysosomal proteomes, we identified cholesterol signaling (LYCHOS, previously annotated as G protein-coupled receptor 155), a multidomain transmembrane protein that enables cholesterol-dependent activation the master regulator, kinase mechanistic target rapamycin complex 1 (mTORC1). Cholesterol bound to amino-terminal permease-like region LYCHOS,...
Pontin is a chromatin remodeling factor that possesses both ATPase and DNA helicase activities. Although frequently overexpressed in human cancers of various types implicated oncogenic functions, the upstream signaling network leading to regulation turn affects transcription downstream target genes has not been extensively studied. Here, we identify methylated by G9a/GLP methyltransferases hypoxic condition potentiates HIF-1α-mediated activation increasing recruitment p300 coactivator subset...
Macroautophagy (hereafter referred to as autophagy) is an essential self-digestion process maintain homeostasis and promote survival in response starvation. Although the components of autophagy cytoplasm have been well studied, little has known about fine-tuning mechanism through epigenetic regulations. Recently, we identified histone arginine methyltransferase CARM1 a new component followed H3R17 dimethylation critical mark starvation-induced autophagy. Upon nutrient starvation, stabilized...
Abstract Autophagy is a catabolic process through which cytoplasmic components are degraded and recycled in response to various stresses including starvation. Recently, transcriptional epigenetic regulations of autophagy have emerged as essential mechanisms for maintaining homeostasis. Here, we identify that coactivator-associated arginine methyltransferase 1 (CARM1) methylates Pontin chromatin-remodeling factor under glucose starvation, methylated binds Forkhead Box O 3a (FOXO3a)....
Abstract The actions of transcription factors, chromatin modifiers and noncoding RNAs are crucial for the programming cell states. Although importance various epigenetic machineries controlling pluripotency embryonic stem (ES) cells has been previously studied, how cooperate with specific factors still remains largely elusive. Here, we find that Pontin remodelling factor plays an essential role as a coactivator Oct4 maintenance in mouse ES cells. Genome-wide analyses reveal share substantial...
Abstract Background With organismal aging, the hypothalamic–pituitary–gonadal (HPG) activity gradually decreases, resulting in systemic functional declines of target tissues including skeletal muscles. Although HPG axis plays an important role health span, how systemically prevents aging is largely unknown. Methods We generated muscle stem cell (MuSC)‐specific androgen receptor (Ar) and oestrogen 2 (Esr2) double knockout (dKO) mice pharmacologically inhibited (Antide) to mimic decreased...
ABSTRACT Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on limiting membranes. Both hydrolytic functions require precise regulation of lysosomal cholesterol content. In Niemann-Pick type C (NPC), loss exporter, NPC1, causes accumulation lysosomes, leading to hyperactivation, disrupted mitochondrial function neurodegeneration. The compositional functional alterations in NPC how aberrant...
Hydrogen sulfide is produced endogenously by a variety of enzymes involved in cysteine metabolism.Clinical data indicate that endogenous levels hydrogen are diminished various forms cardiovascular diseases.The aim the current study was to investigate effects supplementation on cardiac function during reperfusion clinically relevant experimental model cardiopulmonary bypass.Twelve anesthetized dogs underwent hypothermic bypass.After 60 minutes arrest, started after application either saline...
Abstract Lysosomes must maintain integrity of their limiting membrane to ensure efficient fusion with incoming organelles and degradation substrates within lumen. Pancreatic cancer cells upregulate lysosomal biogenesis enhance nutrient recycling stress resistance, but whether dedicated programs for maintaining facilitate pancreatic growth is unknown. Using proteomic-based organelle profiling, we identify the Ferlin family plasma repair factor, Myoferlin, as selectively highly enriched on...
Purpose: To evaluate image quality and cardiovascular enhancement after triphasic injection in 64-slice-CT coronary angiography (c-CTA). Methods: c-CTA of twenty-two asymptomatic patients following (65ml-contrast bolus + mixed 30ml-contrast 20ml-saline 50ml-saline chaser) were retrospectively reviewed. Attenuation the great vessels, cardiac chambers, arteries 13 places measured by region interest. Also, differences between right artery (RCA) chambers (RCA versus atrium or RA; RCA ventricle...