A5019489739- Muscle Physiology and Disorders
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Neurogenetic and Muscular Disorders Research
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Congenital heart defects research
- Genetic Neurodegenerative Diseases
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Genetics and Neurodevelopmental Disorders
- Genetics and Physical Performance
- RNA modifications and cancer
- Virus-based gene therapy research
- Cardiomyopathy and Myosin Studies
Seoul National University
2020-2024
The survival of motor neuron (SMN) protein is a major component the pre-mRNA splicing machinery and required for RNA metabolism. Although SMN has been considered fundamental gene central nervous system, due to its relationship with neuromuscular diseases, such as spinal muscular atrophy, recent studies have also revealed requirement in non-neuronal cells peripheral regions. Here, we report that fibro-adipogenic progenitor subpopulation expressing Dpp4 (Dpp4+ FAPs) system. Furthermore, reveal...
Zolgensma is a gene-replacement therapy that has led to promising treatment for spinal muscular atrophy (SMA). However, clinical trials of have raised two major concerns: insufficient therapeutic effects and adverse events. In recent trial, 30% patients failed achieve motor milestones despite pre-symptomatic treatment. addition, more than 20% showed hepatotoxicity due excessive virus dosage, even after the administration an immunosuppressant. Here, we aimed test whether...
Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal that can contribute to muscle tissue homeostasis and regeneration, as well postnatal maturation lifelong maintenance of the neuromuscular system. Recently, traumatic injury peripheral nerve was shown activate FAPs, suggesting FAPs respond injury. However, questions how sense anatomically distant whether directly regeneration remained unanswered. Here, utilizing single-cell transcriptomics mouse models, we discovered a subset...
During exercise, skeletal muscle is exposed to a low oxygen condition, hypoxia. Under hypoxia, the transcription factor hypoxia-inducible factor-1α (HIF-1α) stabilized and induces expressions of its target genes regulating glycolytic metabolism. Here, using muscle-specific gene ablation mouse model, we show that Brg1/Brm-associated 155 (Baf155), core subunit switch/sucrose non-fermentable (SWI/SNF) complex, essential for HIF-1α signaling in muscle. Muscle-specific Baf155 increases oxidative...
Abstract Age-associated muscle atrophy is a debilitating condition associated with loss of mass and function age that contributes to limitation mobility locomotion. However, the underlying mechanisms how intrinsic changes are largely unknown. Here we report that, age, Mind bomb-1 (Mib1) plays important role in skeletal maintenance via proteasomal degradation-dependent regulation α-actinin 3 (Actn3). The disruption Mib1 myofibers (Mib1 ΔMF ) results alteration type 2 glycolytic myofibers,...
Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal that can contribute to muscle tissue homeostasis and regeneration, as well postnatal maturation lifelong maintenance of the neuromuscular system. Recently, traumatic injury peripheral nerve was shown activate FAPs, suggesting FAPs respond injury. However, questions how sense anatomically distant whether directly regeneration remained unanswered. Here, utilizing single-cell transcriptomics mouse models, we discovered a subset...
Myogenic progenitors (MPs) generate myocytes that fuse to form myofibers during skeletal muscle development while maintaining the progenitor pool, which is crucial for generating sufficient muscle. Notch signaling has been known reserve a population of embryonic MPs primary myogenesis by promoting cell cycle exit and suppressing premature differentiation. However, roles individual receptors (Notch1-4) embryonic/fetal are still elusive. In this study, we found Notch1 Notch2, exhibit highest...
Abstract Background With organismal aging, the hypothalamic–pituitary–gonadal (HPG) activity gradually decreases, resulting in systemic functional declines of target tissues including skeletal muscles. Although HPG axis plays an important role health span, how systemically prevents aging is largely unknown. Methods We generated muscle stem cell (MuSC)‐specific androgen receptor (Ar) and oestrogen 2 (Esr2) double knockout (dKO) mice pharmacologically inhibited (Antide) to mimic decreased...
Abstract Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal that can contribute to muscle tissue homeostasis and regeneration, as well postnatal maturation lifelong maintenance of the neuromuscular system. Recently, traumatic injury peripheral nerve was shown activate FAPs, suggesting FAPs respond injury. However, questions how sense anatomically distant whether directly regeneration remained unanswered. Here, utilizing single-cell transcriptomics mouse models, we discovered...
Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal that can contribute to muscle tissue homeostasis and regeneration, as well postnatal maturation lifelong maintenance of the neuromuscular system. Recently, traumatic injury peripheral nerve was shown activate FAPs, suggesting FAPs respond injury. However, questions how sense anatomically distant whether directly regeneration remained unanswered. Here, utilizing single-cell transcriptomics mouse models, we discovered a subset...
Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal that can contribute to muscle tissue homeostasis and regeneration, as well postnatal maturation lifelong maintenance of the neuromuscular system. Recently, traumatic injury peripheral nerve was shown activate FAPs, suggesting FAPs respond injury. However, questions how sense anatomically distant whether directly regeneration remained unanswered. Here, utilizing single-cell transcriptomics mouse models, we discovered a subset...
<title>Abstract</title> Background Muscle stem cells (MuSCs) undergo numerous state transitions throughout life, which are critical for supporting normal muscle growth and regeneration. Therefore, it is crucial to investigate the regulatory mechanisms governing transition of MuSC states across different postnatal developmental stages. Methods To assess if myofiber-expressed Mll4 contributes maintenance MuSCs, we crossed <italic>MCK</italic><sup><italic>Cre/+</italic></sup> or...
Abstract Background Muscle stem cells (MuSCs) undergo numerous state transitions throughout life, which are critical for supporting normal muscle growth and regeneration. Epigenetic modifications in skeletal play a significant role influencing the niche cellular states of MuSCs. Mixed-lineage leukemia 4 (Mll4) is histone methyltransferase activating transcription various target genes highly expressed muscle. This raises question whether Mll4 has regulatory function modulating MuSCs,...