A5086338867- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Polymer crystallization and properties
- Radiopharmaceutical Chemistry and Applications
- Autophagy in Disease and Therapy
- Nanowire Synthesis and Applications
- Asymmetric Synthesis and Catalysis
- Advanced Polymer Synthesis and Characterization
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Liquid Crystal Research Advancements
- Mitochondrial Function and Pathology
- Advancements in Semiconductor Devices and Circuit Design
- Cancer, Hypoxia, and Metabolism
- Synthesis and properties of polymers
- Parkinson's Disease Mechanisms and Treatments
- Acute Myeloid Leukemia Research
- Advanced X-ray and CT Imaging
- Advanced X-ray Imaging Techniques
- Blind Source Separation Techniques
- Fullerene Chemistry and Applications
- Psoriasis: Treatment and Pathogenesis
- Multisensory perception and integration
- Robotics and Sensor-Based Localization
- Sirtuins and Resveratrol in Medicine
Seoul National University
2010-2024
Seoul National University Hospital
2007-2019
Biomedical Research Institute
2016
New Generation University College
2008
Korea Institute of Industrial Technology
2004
Clemson University
2003
Significance VDAC1 transports ions and small molecules at the mitochondrial outer membrane. In this study, we discover that Parkin, a frequently mutated Parkinson disease protein, ubiquitinates in two different manners, poly- monoubiquitination. Interestingly, defective polyubiquitination hinders Parkin-mediated mitophagy, but monoubiquitination induces apoptosis. When deficient with is expressed mammalian cells fruit fly, observe increased calcium influx apoptosis typical vivo phenotypes...
This paper presents an adaptive image-based visual servoing (IBVS) integratedwith slidingmode control for a vision-based operation of quadrotor unmanned aerial vehicle (UAV). For seamless integration with underactuated dynamics, roll and pitch channels are decoupled from the other using virtual features. allows simple accurate algorithm estimating depth information successful application proposed guidance algorithm.By employing gain in IBVS controlmethod, chance image feature loss is...
Loss of UCHL1 activates an energy-dependent mitophagy via pyruvate kinase, which relieves Parkinson’s disease symptoms.
Diabetic sensory neuropathy (DSN) is one of the most common complications type 2 diabetes (T2D), however molecular mechanistic association between T2D and DSN remains elusive. Here we identify ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitinase highly expressed in neurons, as key molecule underlying DSN. Genetic ablation UCHL1 leads to neuronal insulin resistance T2D-related symptoms Drosophila. Furthermore, loss induces DSN-like phenotypes, including numbness external noxious...
We evaluated the clinical usefulness (leukocyte distribution classification, morphologic and flags) of following four hematology analyzers: CELL-DYN Sapphire (CD-Sapphire) (Abbott Diagnostics, Santa Clara, CA, USA), ADVIA 120 (Bayer Tarrytown, NY, Beckman Coulter LH 750 (Beckman Coulter, Miami, FL, Sysmex XE-2100 (TOA Medical Electronics Co., Kobe, Japan). Four hundred thirty samples from patients 100 healthy individuals were analyzed. For distributional sensitivity rates CD-Sapphire, 120,...
SUMMARY To determine whether there are differences in the immunopathogenesis of different endogenous uveitis syndromes, phenotypic characteristics immune cells were analysed among patients with uveitis. The aetiology included idiopathic recurrent acute anterior (18 patients), intermediate (13 Behçet's (17 Vogt–Koyanagi–Harada syndrome (7 and so on. Flow cytometric analysis was performed using aqueous humor peripheral blood during active phase intraocular inflammation, monoclonal antibodies...
<b><i>Objective:</i></b> To determine the ictal focus and role of seizure characteristics, fluorodeoxyglucose (FDG) PET, subtraction SPECT in patients diagnosed as having nonlesional lateral temporal lobe epilepsy by long-term scalp video-EEG monitoring. <b><i>Methods:</i></b> The authors studied 33 consecutive with neocortical who had a onset zone localized good surgical outcome after focal resection. All were evaluated using intracranial recordings prior to Semiology, FDG-PET,...
The temperature dependent thermoelectric power (TEP) of boron- and nitrogen-doped multiwalled carbon nanotube mats has been measured showing that such dopants can be used to modify the majority conduction from p-type n-type. TEP boron-doped nanotubes is positive, indicating hole-like carriers. In contrast, nitrogen doped material exhibits negative over same range, suggesting electron-like conduction. Therefore, distinct nonlinearities are primarily due formation donor acceptor states in B-...
A cross-sectional study evaluated the prevalence of and risk factors for hepatitis C B viruses among 700 adults above age 40 years in a rural area South Korea. Seropositivity virus antibody (11.0%, 95% confidence interval: 8.7–13.6) was higher than that surface antigen (4.4%, 3.0–6.2). Anti-hepatitis seropositivity associated with history repeated acupuncture (odds ratio=2.1, 1.1–4.0), blood transfusion ratio=5.5, 1.6–19.3) before 1992 when screening donors became mandatory. Hepatitis 2a...
The isothermal crystallization kinetics of maleic anhydride grafted polypropylene (mPP) in hybrids with unmodified or organically modified montmorillonite (MMT), which have been prepared by melt intercalation a mixer, has investigated using time-resolved wide-angle X-ray scattering (WAXS) and differential scanning calorimetry (DSC). WAXS transmission electron microscopy (TEM) showed that the mPP/unmodified MMT formed macrophase-separated mixtures rather than intercalated nanocomposites,...
Recent technological advances have made it possible to record a variety of platelet indices using automated hematology analyzers. Disseminated intravascular coagulation (DIC) is associated with the dramatic hemostasis activation, evidence fibrin formation and consumption. We investigated prognostic significance as measured by ADVIA in 222 patients suspected having DIC. The presence overt DIC was defined scoring system International Society Thrombosis Haemostasis Subcommittee. Twenty-eight...
During exercise, skeletal muscle is exposed to a low oxygen condition, hypoxia. Under hypoxia, the transcription factor hypoxia-inducible factor-1α (HIF-1α) stabilized and induces expressions of its target genes regulating glycolytic metabolism. Here, using muscle-specific gene ablation mouse model, we show that Brg1/Brm-associated 155 (Baf155), core subunit switch/sucrose non-fermentable (SWI/SNF) complex, essential for HIF-1α signaling in muscle. Muscle-specific Baf155 increases oxidative...
Differences in the clinical course of secondary acute myeloid leukemia according to type preceding disorders are not defined. We compared outcomes therapy-related leukemia, following myelodysplastic syndrome and myeloiod myeloproliferative neoplasm. also intended find prognostic factors overall.Retrospective medical record review at Seoul National University Hospital was performed. assessed response induction chemotherapy overall survival.Ninety-five patients (median age 56.4 years) were...
Dopamine dysregulation has been implicated in the pathophysiology of schizophrenia. The present study was performed to examine whether unaffected relatives at high genetic risk schizophrenia have dopamine comparison with healthy controls.Eleven from families two or more first- second-degree (n = 9) a monozygotic schizophrenic twin 2) and 11 age- sex-matched controls were examined using positron emission tomography (PET) [(11)C] raclopride. Subjects also underwent extensive neuropsychological...
Abstract The temperature dependence of thermal, morphological, and rheological properties amphiphilic polyurethanes was examined with differential scanning calorimetry (DSC), wide‐angle X‐ray scattering (WAXS), small‐angle (SAXS), measurements, Fourier transform infrared spectroscopy. Multiblock (MPU) triblock (TPU) were synthesized two crystallizable segments—poly(ethylene oxide) (PEO) as a hydrophilic block poly(tetramethylene (PTMO) hydrophobic block. DSC WAXS measurements demonstrated...
Technical Briefs Analytical Solutions for the Developing Jet From a Fully-Developed Laminar Tube Flow D. S. Lee, Lee Department of Mechanical Engineering, Seoul National University, 151-742, Korea Search other works by this author on: This Site PubMed Google Scholar K. Kihm, Kihm Texas A&M College Station, TX 77843-3123 H. Chung Author and Article Information J. Fluids Eng. Sep 1997, 119(3): 716-718 (3 pages) https://doi.org/10.1115/1.2819304 Published Online: September 1, 1997 history...
Exemestane has shown good efficacy and tolerability in postmenopausal women with hormone receptor-positive metastatic breast cancer. However, clinical outcomes Korean patients have not yet been reported.Data on 112 cancer were obtained retrospectively. Clinicopathological characteristics treatment history extracted from medical records. All received 25 mg exemestane daily until objective disease progression. Progression-free survival (PFS) was the primary endpoint, secondary endpoints...