Seung‐Heon Lee

ORCID: 0000-0002-0578-7653
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About
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Research Areas
  • Terahertz technology and applications
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Agriculture, Soil, Plant Science
  • Mycobacterium research and diagnosis
  • Nonlinear Optical Materials Research
  • Tuberculosis Research and Epidemiology
  • Spectroscopy and Laser Applications
  • Acoustic Wave Resonator Technologies
  • Crystallography and molecular interactions
  • Photonic and Optical Devices
  • Ecology and Conservation Studies
  • Infectious Diseases and Mycology
  • Block Copolymer Self-Assembly
  • Fluid Dynamics and Thin Films
  • Solid-state spectroscopy and crystallography
  • Antifungal resistance and susceptibility
  • Fungal Infections and Studies
  • Soil Carbon and Nitrogen Dynamics
  • Polymer crystallization and properties
  • Luminescence and Fluorescent Materials
  • Traffic Prediction and Management Techniques
  • Peptidase Inhibition and Analysis
  • Advanced Chemical Sensor Technologies
  • Diagnosis and treatment of tuberculosis

Dankook University
2025

Yonsei University
2020-2024

Animal and Plant Quarantine Agency
2018-2023

Ajou University
2012-2021

Korea Rural Economic Institute
2007-2020

Hanyang University
2018

Suwon Research Institute
2018

Ministry of Agriculture, Food and Rural Affairs
2018

Jeju National University
2015

Korea National Tuberculosis Association
2009-2014

Rationale: Mycobacterium massiliense has been recognized as a separate species from abscessus; however, little is known regarding the clinical impact of this differentiation.Objectives: To compare features and treatment outcomes between patients with M. abscessus lung disease those disease.Methods: We performed molecular identification stored isolates complex compared characteristics 64 81 disease.Measurements Main Results: The radiographic manifestations caused by each were similar....

10.1164/rccm.201003-0395oc article EN American Journal of Respiratory and Critical Care Medicine 2010-09-11

Rationale: The optimal therapeutic regimen and duration of treatment for Mycobacterium abscessus lung disease is not well established.Objectives: To assess the efficacy a standardized combination antibiotic therapy M. disease.Methods: Sixty-five patients (11 males, 55 females, median age yr) with were treated clarithromycin, ciprofloxacin, doxycycline, together an initial amikacin cefoxitin first 4 weeks hospitalization.Measurements Main Results: Treatment response rates 83% symptoms 74%...

10.1164/rccm.200905-0704oc article EN American Journal of Respiratory and Critical Care Medicine 2009-08-07

Abstract Background Treatment outcomes of patients with Mycobacterium abscessus subspecies lung disease are poor, and the microbial characteristics associated treatment have not been studied systematically. The purpose this study was to identify associations between in M. disease. Methods Sixty-seven consecutive undergoing antibiotic for ≥12 months January 2002 December 2012 were included. Morphotypic genetic analyses performed on isolates from 44 patients. Results Final sputum conversion...

10.1093/cid/ciw724 article EN Clinical Infectious Diseases 2016-10-24

The high-power broadband terahertz (THz) generator is an essential tool for a wide range of THz applications. Here, we present novel highly efficient electro-optic quinolinium single crystal wave generation. For obtaining intense and waves by optical-to-THz frequency conversion, was developed to fulfill all the requirements, which are in general extremely difficult maintain simultaneously medium, such as large macroscopic response excellent characteristics including size with desired facets,...

10.1038/srep03200 article EN cc-by-nc-nd Scientific Reports 2013-11-13

Macrolide antibiotics are key components of the multidrug treatment regimen for treating lung disease (LD) due to Mycobacterium avium complex (MAC). Despite emergence macrolide resistance, limited data available on macrolide-resistant MAC-LD. This study evaluated clinical features and outcomes patients with MAC-LD molecular characteristics isolates. A retrospective review medical records 34 who were diagnosed between January 2002 December 2014 was performed, along genetic analysis 28...

10.1128/aac.01240-16 article EN Antimicrobial Agents and Chemotherapy 2016-08-30

Abstract This study reports a new nonfullerene electron transporting material (ETM) based on naphthalene diimide (NDI) small molecules for use in high‐performance perovskite solar cells (PSCs). These simultaneously achieve high power conversion efficiency (PCE) of over 20% and long‐term stability. New NDI‐ID ( N , N′ ‐Bis(1‐indanyl)naphthalene‐1,4,5,8‐tetracarboxylic diimide) consisting an ‐substituted indane group having simultaneous alicyclic aromatic characteristics is synthesized by...

10.1002/adfm.201800346 article EN Advanced Functional Materials 2018-03-25

During the past decade, various new types of organic nonlinear optical crystals have been developed to overcome benchmark stilbazolium DAST (4-(4-(N,N-dimethylamino)styryl)-1-methylpyridinium 4-methylbenzenesulfonate) crystal. Here, we review acentric core structures used in recently exhibiting high macroscopic second-order nonlinearity, along with their supramolecular interactions and THz applications. The such as neutral CLP (configurationally locked polyene based on phenyltriene), ionic...

10.1039/c6ce00707d article EN CrystEngComm 2016-01-01

Moxifloxacin (MXF) has in vitro and vivo activity against Mycobacterium avium complex (MAC) experimental models. However, no data are available concerning its treatment effect patients with MAC lung disease. The aim of this study was to evaluate the clinical efficacy an MXF-containing regimen for refractory Patients disease who were diagnosed between January 2002 December 2011 identified from our hospital database. We 41 received MXF ≥ 4 weeks A total treated because a persistent positive...

10.1128/aac.02281-12 article EN Antimicrobial Agents and Chemotherapy 2013-03-12

We report on the generation of continuously tunable multi-cycle THz pulses with center frequencies from 0.3 to 0.8 in organic nonlinear crystal, HMQ-TMS [2-(4-hydroxy-3-methoxystyryl)-1-methylquinolinium 2,-4,-6-trimethylbenzenesulfonate], by collinearly phase matched optical rectification temporally shaped 800 nm pulses. The harmonic frequency components inherent pulse shaper is selectively suppressed varying crystal thickness. generated show up 20 times higher energies compared benchmark...

10.1364/oe.23.022723 article EN cc-by Optics Express 2015-08-20

Organic electrooptic crystals based on a new acentric core structure 2-(4-hydro­xystyryl)-1-methylquinolinium provide optimal molecular packing for maximizing the response. They allow intense broadband terahertz generation with over 30 times higher efficiency compared to widely used inorganic ZnTe. As service our authors and readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized online delivery, but not copy-edited or...

10.1002/adom.201400502 article EN Advanced Optical Materials 2015-02-11

ABSTRACT Macrolide antibiotics are mainstays in the treatment of lung disease due to Mycobacterium abscessus complex. Although previous studies have reported development acquired macrolide resistance this species, limited data available on outcomes macrolide-resistant subsp. . This study evaluated clinical features, outcomes, and molecular characteristics isolates M. We performed a retrospective review medical records genetic analysis from 13 patients who had between November 2006 March...

10.1128/aac.01146-17 article EN Antimicrobial Agents and Chemotherapy 2017-07-25

Phosphatases, together with kinases and transcription factors, are key components in cellular signalling networks. Here, we present a systematic functional analysis of the phosphatases Cryptococcus neoformans, fungal pathogen that causes life-threatening meningoencephalitis. We analyse 230 signature-tagged mutant strains for 114 putative under 30 distinct vitro growth conditions, revealing at least one function 60 these proteins. Large-scale virulence infectivity assays using insect mouse...

10.1038/s41467-020-18028-0 article EN cc-by Nature Communications 2020-08-24

Solid oxide fuel cells (SOFCs) are attracting attention as an eco-friendly power source because they show high density. However, SOFC requires a high-temperature environment of 800 °C or higher, and accordingly, the problem thermal stability material constituting has been raised. On other hand, low-temperature solid (LT-SOFCs) research is steadily progressing to improve electrochemical performance at low temperatures by improving oxygen reduction reaction cathode applying interlayer various...

10.3390/su17041403 article EN Sustainability 2025-02-08

Polyaniline/Na+-montmorillonite (Na+-MMT) nanocomposites synthesized by in-situ intercalative polymerization of aniline into Na+-MMT are reported. The expansion distribution basal spacing the silicate layers upon increase amount relative to is, for first time, estimated from square full-width at half-maximum (FWHM2) XRD patterns. According FT-IR frequency shift C-N stretching vibration, change in is closely related degree hydrogen bonding between polyaniline and surface a confined geometry.

10.1002/1521-3927(20001101)21:16<1136::aid-marc1136>3.0.co;2-s article EN Macromolecular Rapid Communications 2000-11-01

Magnetic colloidal nanocrystals tend to aggregate in solution because of magnetic dipolar interactions. A diblock copolymer was used as a stabilizer limit these effects, especially those leading aggregation solution. Cobalt nanoparticles have been synthesized within inverse micelles polystyrene-block-poly(2-vinylpyridine) toluene by the pyrolysis dicobalt octacarbonyl at 115 °C. The nanoparticle structure different reaction times investigated using transmission electron microscopy (TEM) and...

10.1021/nl034262l article EN Nano Letters 2003-06-24

We show that the organic electro-optic crystal HMQ-TMS [2-(4-hydroxy-3-methoxystyryl)-1-methylquinolinium 2,4,6-trimethylbenzenesulfonate] has favorable properties for parametric generation of THz waves in a collinear type-0 phase-matching scheme, i.e., low absorption coefficient at wavelengths from 800 to 1500 nm (α 0.5 mm). demonstrate efficient broadband pulses through optical rectification sub-picosecond laser 0.2 mm thick wavelength 1000 nm. The energy conversion efficiency achieved...

10.1364/ome.4.001586 article EN cc-by Optical Materials Express 2014-07-14

ABSTRACT Macrolide antibiotics are cornerstones in the treatment of Mycobacterium massiliense lung disease. Despite emergence resistance, limited data on macrolide-resistant M . disease available. This study evaluated clinical features and outcomes patients molecular characteristics isolates. We performed a retrospective review medical records genetic analyses isolates from 15 who had between September 2005 February 2015. Nine (60%) nodular bronchiectatic form disease, six (40%)...

10.1128/aac.02189-16 article EN Antimicrobial Agents and Chemotherapy 2016-11-21

The isothermal crystallization kinetics of maleic anhydride grafted polypropylene (mPP) in hybrids with unmodified or organically modified montmorillonite (MMT), which have been prepared by melt intercalation a mixer, has investigated using time-resolved wide-angle X-ray scattering (WAXS) and differential scanning calorimetry (DSC). WAXS transmission electron microscopy (TEM) showed that the mPP/unmodified MMT formed macrophase-separated mixtures rather than intercalated nanocomposites,...

10.1021/ie049825y article EN Industrial & Engineering Chemistry Research 2004-08-13

Abstract This study reports on highly efficient nonlinear optical ionic quinolinium crystals with various aromatic anions possessing different spatial volume for controlling the space‐filling characteristics and introducing halogen substituents having simultaneous electron‐withdrawing electron‐donating effects. The chloro bromo effects exhibit perfect molecular ordering optimizing diagonal second‐order response, while fluoro substituent relatively small results in absence of response....

10.1002/adom.201700930 article EN Advanced Optical Materials 2017-12-13

Three mycobacterial strains, isolated from independent Korean patients with pulmonary infections, belonging to the Mycobacterium intracellulare genotype 1 (INT-1) were characterized using a polyphasic approach. The sequences of 16S rRNA gene and internal transcribed spacer (ITS1) INT-1 strains identical those ATCC 13950T. However, multilocus sequence typing (MLST) analysis targeting five housekeeping genes (hsp65, rpoB, argG, gnd pgm) revealed phylogenetic separation these M. DNA-DNA...

10.1099/ijsem.0.001158 article EN INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY 2016-05-17

We report on efficient generation of ultra-broadband terahertz (THz) waves via optical rectification in a novel nonlinear organic crystal with acentric core structure, i.e. 2-(4-hydroxystyryl)-1-methylquinolinium 4-methylbenzenesulfonate (OHQ-T), which possesses an ideal molecular structure leading to maximized response for near-infrared-pumped THz wave generation. By systematic studies wavelength-dependent phase-matching conditions OHQ-T crystals different thicknesses we are able generate...

10.1364/oe.24.011054 article EN cc-by Optics Express 2016-05-11
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