A5077849701- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Tuberculosis Research and Epidemiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mycobacterium research and diagnosis
- Tracheal and airway disorders
- Pediatric health and respiratory diseases
- Dysphagia Assessment and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory viral infections research
- Pleural and Pulmonary Diseases
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Esophageal and GI Pathology
- Pneumocystis jirovecii pneumonia detection and treatment
- Asthma and respiratory diseases
- Health and Wellbeing Research
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- COVID-19 and healthcare impacts
- Helicobacter pylori-related gastroenterology studies
- Renal cell carcinoma treatment
- Sepsis Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Diverse Approaches in Healthcare and Education Studies
Hallym University Kangnam Sacred Heart Hospital
2018-2025
Seoul National University
2017-2025
Hallym University
1998-2024
Kyungpook National University
2024
University of Dundee
2022-2024
Hallym Polytechnic University
2024
Dankook University
2024
Ninewells Hospital
2022-2023
Chungnam National University Hospital
2023
Korea Research Institute of Bioscience and Biotechnology
2017-2022
Formerly regarded as a rare disease, bronchiectasis is increasingly recognised. A renewed interest in this disease has led to significant progress research. Randomised clinical trials (RCTs) have demonstrated the benefits of airway clearance techniques, inhaled antibiotics and long-term macrolide therapy patients. However, heterogeneity remains one most challenging aspects management. Phenotypes endotypes been identified help find “treatable traits” partially overcome complexity. The goals...
Background There are limited data regarding the relationship between interstitial lung disease (ILD) and natural course of COVID-19. In this study, we investigate whether patients with ILD more susceptible to COVID-19 than those without evaluate impact on severity in Methods A nationwide cohort (n=8070) a 1:15 age-, sex- residential area-matched (n=121 050) were constructed 1 January 2020 30 May Korea. We performed nested case–control study compare proportions matched cohort. Using cohort,...
Abstract To address the drug-resistance of bacterial pathogens without imposing a selective survival pressure, virulence and biofilms are highly attractive targets. Here, we show that terrein, which was isolated from Aspergillus terreus , reduced factors (elastase, pyocyanin, rhamnolipid) biofilm formation via antagonizing quorum sensing (QS) receptors affecting Pseudomonas aeruginosa cell growth. Additionally, effects terrein on production QS signaling molecules expression QS-related genes...
Rationale: Although inflammation and infection are key disease drivers in bronchiectasis, few studies have integrated host inflammatory microbiome data to guide precision medicine. Objectives: To identify clusters among patients with bronchiectasis on the basis of markers assess association between endotypes, characteristics, exacerbation risk. Methods: Patients stable were enrolled at three European centers, cluster analysis was used stratify according levels 33 sputum serum markers....
Abstract Background Few studies have comprehensively evaluated the risk of lung cancer in tuberculosis survivors with consideration smoking status and chronic obstructive pulmonary disease (COPD). Furthermore, little is known about factors survivors. Methods This population-based cohort study enrolled (n = 75 467) between 2010 2017 1:1 age- sex-matched controls. Subjects were followed up for 1 year from date diagnosis to incident cancer, death, or December 2018, whichever came first. The was...
Bronchiectasis is characterized by acute exacerbations, but the biological mechanisms underlying these events are poorly characterized.
METHODS:This study calculated sex-standardized and age-standardized prevalence of CVD smoking indices in 253 community health centers (si/gun/gu) Korea using the 2008-2013 Community Health Survey data.Furthermore, a Bayesian hierarchical model was used to estimate association passive with from national regional centers. RESULTS:At level, significantly associated stroke (relative risk [RR], 1.060) hypertension (RR, 1.016) prevalence, whilst at home work were also 1.037/1.013),angina...
Understanding the aetiology and characteristics of patients with bronchiectasis is vital for developing strategies to reduce burden disease; however, geographical variations in these characteristics, which may have important implications diagnosis treatment,1, 2 make it difficult formulate a uniform strategy investigation. Here, we describe illness treatment among Korean compare results those from three geographically ethnically diverse regions: Australia, Europe India. The Multicentre...
Abstract There are limited data regarding whether mortality is higher in patients with non cystic fibrosis bronchiectasis (bronchiectasis) than those without bronchiectasis. Using 2005–2015 from the Korean National Health Insurance Service, we evaluated hazard ratio (HR) for all-cause cohort relative to matched cohort. The effect of comorbidities over study period on was also assessed. All-cause significantly (2505/100,000 vs 2142/100,000 person-years, respectively; P < 0.001). Mortality...
When assessing long-term tuberculosis (TB) mortality, few studies addressed the impact of behavior habits and socioeconomic status. Therefore, we aimed to evaluate TB mortality risk factors while accounting for potential confounders.This cohort study included survivors (n = 82 098) aged ≥20 years between 2010 2017, 1:1 age- sex-matched controls 098). The participants were followed up death 1 year after enrollment until December 2018. Long-term was adjusted (smoking, alcohol consumption, or...
Rationale: It remains unclear whether non-cystic fibrosis bronchiectasis increases the risk of lung cancer, because smoking history was not considered in previous studies. Objectives: To evaluate participants with have a higher incident cancer than those without information on status. Methods: This population-based cohort study 3,858,422 individuals who participated 2009 National Health Screening Program. We evaluated incidence (n = 65,305) and 3,793,117). followed up until date diagnosis,...
The association between systemic sclerosis and the development of bronchiectasis is unclear. This study aimed to compare risk individuals with those without using a nationwide longitudinal dataset.Using Korean National Health Insurance Service dataset 2010 2017, we identified 4845 aged ≥ 20 years 24,225 who were matched 1:5 by age sex. They followed up until date diagnosis, death, or December 31, 2019, whichever came first.During median follow-up period 6.0 (interquartile range, 3.2-8.7)...
ABSTRACT Macrolide antibiotics are mainstays in the treatment of lung disease due to Mycobacterium abscessus complex. Although previous studies have reported development acquired macrolide resistance this species, limited data available on outcomes macrolide-resistant subsp. . This study evaluated clinical features, outcomes, and molecular characteristics isolates M. We performed a retrospective review medical records genetic analysis from 13 patients who had between November 2006 March...
Pleural tuberculosis (TB), a form of extrapulmonary TB, can be difficult to diagnose. High numbers lymphocytes in pleural fluid have been considered part the diagnostic criteria for TB; however, many cases, neutrophils rather than are predominant cell type effusions, making diagnosis more complicated. Additionally, there is limited information on clinical and laboratory characteristics neutrophil-predominant effusions caused by Mycobacterium (MTB). To investigate differences between...
Conflicting results exist regarding the risk of ischemic stroke in tuberculosis survivors. We aimed to estimate using a nationwide population-based retrospective cohort.We gathered data from Korean National Health Insurance Service on survivors and 1:1 age- sex-matched non-tuberculosis cases. Eligible participants were followed up 1 year after diagnosis date event, death, or until end study period (December 31, 2018), whichever came first. Cox proportional hazard regression stratified...
Abstract Background Little is known about the risk of ischemic heart disease (IHD) in tuberculosis (TB) survivors. Methods We performed a population-based retrospective cohort study using Korean National Health Insurance Service database. TB survivors (n = 60 602) and their 1:1 age- sex-matched controls were enrolled. Eligible participants followed up from 1 year after diagnosis to date an IHD event, death, or end period (31 December 2018), whichever came first. The was estimated Cox...
Background Individuals with bronchiectasis have an increased risk of exacerbation by coronavirus 2019 (COVID-19), even after recovery from COVID-19. However, the impact COVID-19 severity on severe and mortality remains uncertain. Methods We enrolled 48 342 individuals diagnosed between January 1, 2015 October 7, 2020 Korea National Health Insurance Service. Of these individuals, 2711 were identified as also having recovered A matched cohort (n=2711 for both) established 1:1 propensity...
Interstitial lung disease (ILD) leads to worse outcomes in subjects with rheumatoid arthritis (RA). Few large-scale longitudinal studies have provided comprehensive data on the incidence and risk of ILD RA compared non-RA populations. We compare incident matched controls, while also evaluating impact serologic status. Using Korean National Health Insurance Service Data between 2010 2017, we identified 52,325 individuals 261,625 without RA. During a median follow-up period 4.4 years, 3.7%...