A5007748052- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Lung Cancer Treatments and Mutations
- Asthma and respiratory diseases
- Pleural and Pulmonary Diseases
- Mycobacterium research and diagnosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tuberculosis Research and Epidemiology
- Pediatric health and respiratory diseases
- Infectious Diseases and Mycology
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Cardiovascular and exercise physiology
- Venous Thromboembolism Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Health and Wellbeing Research
- Atrial Fibrillation Management and Outcomes
- Stroke Rehabilitation and Recovery
- Ergonomics and Musculoskeletal Disorders
- Chronic Disease Management Strategies
- Musculoskeletal pain and rehabilitation
- Diagnosis and treatment of tuberculosis
- Tracheal and airway disorders
- Mechanical Circulatory Support Devices
Samsung Medical Center
2016-2025
Sungkyunkwan University
2016-2025
California Pacific Medical Center
2024
Pulmonary and Critical Care Associates
2021-2023
Molina Center for Energy and the Environment
2019
Universiti Teknologi MARA
2019
Izumi City General Hospital
2019
Jeonbuk National University
2014-2017
Korea Research Institute of Chemical Technology
2014-2015
BongSeng Memorial Hospital
2014
There has been limited evidence for the association between chronic obstructive pulmonary disease (COPD) and incidence of lung cancer among never smokers. We aimed to estimate risk in smokers with COPD, compare it associated smoking. This cohort study involved 338 548 subjects, 40 84 years age no history at baseline, enrolled National Health Insurance Service Sample Cohort. During 2 355 005 person-years follow-up (median 7.0 years), 1834 participants developed cancer. Compared without...
Chronic obstructive pulmonary disease (COPD) is often accompanied by multiple comorbidities, which are associated with an increased risk of exacerbation, a poor health-related quality life, and high mortality. However, differences in comorbidity profile race ethnicity COPD patients have not been fully elucidated.Participants aged 40 to 79 years spirometry-defined from the U.S. National Health Nutrition Examination Survey (NHANES) (2007-2012) Korea NHANES (2007-2015) were analyzed compare...
The prevalence of lung cancer has been increasing in healthy elderly patients with preserved pulmonary function and without underlying diseases. We aimed to determine the risk factors for postoperative complications (PPCs) non-small cell (NSCLC) select optimal candidates surgical resection this subpopulation. included 488 older than 70 years normal spirometry results who underwent curative NSCLC (stage IA-IIB) between 2012 2016. median (interquartile range) age our cohort was 73 (71–76)...
Rationale: It remains unclear whether non-cystic fibrosis bronchiectasis increases the risk of lung cancer, because smoking history was not considered in previous studies. Objectives: To evaluate participants with have a higher incident cancer than those without information on status. Methods: This population-based cohort study 3,858,422 individuals who participated 2009 National Health Screening Program. We evaluated incidence (n = 65,305) and 3,793,117). followed up until date diagnosis,...
Abstract Methylation patterns in cell-free DNA (cfDNA) have emerged as a promising genomic feature for detecting the presence of cancer and determining its origin. The purpose this study was to evaluate diagnostic performance methylation-sensitive restriction enzyme digestion followed by sequencing (MRE-Seq) using cfDNA, investigate signal origin (CSO) deep neural network (DNN) analyses liquid biopsy colorectal lung cancer. We developed selective MRE-Seq method with DNN learning-based...
The association between longitudinal body mass index (BMI) change and clinical outcomes in patients with chronic obstructive pulmonary disease (COPD) has not fully investigated. This retrospective cohort study included 116,463 COPD aged ≥ 40, at least two health examinations, one within 2 years before another 3 after diagnosis (January 1, 2014, to December 31, 2019). Associations BMI percentage all-cause mortality, primary endpoint, initial severe exacerbation were assessed. decreased > 5%...
Blood eosinophils have been suggested as a potential biomarker in chronic obstructive pulmonary disease (COPD), and their stability over time has investigated few studies. However, the association between of blood long-term clinical outcomes COPD patients yet to be fully elucidated. This study aimed evaluate its with patients. In total, 299 from Korean Obstructive Lung Disease cohort at least two eosinophil measurements were included. Patients stratified according cut-off 300 cells/μL,...
Guidelines recommend invasive mediastinal staging for centrally located tumours, even in radiological N0 nonsmall cell lung cancer (NSCLC). However, there is no uniform definition of a central tumour that more predictive occult metastasis.A total 1337 consecutive patients with disease underwent staging. Tumours were categorised into and peripheral by seven different definitions.About 7% (93 out 1337) had N2 disease, they significantly larger size solid tumours on computed tomography. After...
ABSTRACT Background and objective The global burden of chronic obstructive pulmonary disease (COPD) is increasing COPD patients are at higher risk for all‐cause mortality. We aimed to evaluate the impact on specific‐cause mortality using national data. Methods This was nationwide retrospective cohort study 340, 767 adults aged 40–84 years who lacked diagnosis baseline between 1 January 2003 31 December 2013. Incident defined by reference claim codes prescription medication least twice...
Aim The impact of blood eosinophil counts on the development chronic obstructive lung disease (COPD) is unknown. We investigated whether a higher count was associated with risk developing (OLD) in large cohort men and women free from at baseline. Methods This study 359 456 Korean adults without history asthma OLD baseline who participated health screening examinations including spirometry. defined as pre-bronchodilator forced expiratory volume 1 s (FEV )/forced vital capacity (FVC) <0.7...
Lung cancer diagnostic guidelines advocate for invasive mediastinal nodal staging (IMNS), but the survival benefits of this approach in patients with non-small cell lung (NSCLC) without radiologic evidence lymph node metastasis (rN0) remain uncertain. We aimed to investigate impact IMNS rN0 NSCLC by comparing long-term between who underwent and those did not (non-IMNS).
Background Accelerated lung function decline is characteristic of COPD. However, the association between blood eosinophil counts and decline, accounting for current smoking status, in young individuals without prevalent disease not fully understood. Methods This a cohort study 629 784 Korean adults COPD or history asthma at baseline who participated health screening examinations including spirometry differential white cell counts. We used linear mixed-effects model to estimate annual change...
Abstract Detecting aberrant cell-free DNA (cfDNA) methylation is a promising strategy for lung cancer diagnosis. In this study, our aim to identify markers distinguish patients with from healthy individuals. Additionally, we sought develop deep learning model incorporating cfDNA and fragment size profiles. To achieve this, utilized data collected The Cancer Genome Atlas Gene Expression Omnibus databases. Then generated methylated immunoprecipitation sequencing genome-wide Enzymatic...
Emerging immune profiling data suggest a higher sensitivity to checkpoint inhibitors (ICIs) in nonsmall cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD), compared those without COPD. This study aimed investigate the clinical impact of COPD on treatment response ICIs large number NSCLC. In total, 133 spirometry test results were retrospectively identified among who received palliative pembrolizumab for was defined as pre-bronchodilator forced expiratory...
Rationale: Although a history of pulmonary tuberculosis (PTB) is risk factor for developing both chronic obstructive disease (COPD) and lung cancer, it remains unclear whether PTB affects cancer development in patients with COPD. Objectives: To investigate associated an increased population Methods: This cohort study included nationwide representative sample 13,165 Korean men women COPD, aged between 50 84 years. In addition, to assess the relationship differs participants without matched...
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become a standard procedure, but little is known about its infectious complications. The aim of this study to evaluate the incidence and risk factors complications EBUS-TBNA clinical course, including effects on anti-cancer treatment.
The effects of smoking reduction on the incidence lung cancer in patients with chronic obstructive pulmonary disease (COPD) are not well known. This study aimed to investigate changes habits after COPD diagnosis development who smoked less than 30 pack-years. nationwide retrospective cohort included 16,832 pack-years at time diagnosis. Based health screening examination data, smokers were categorized into three groups: quitters, reducers, and sustainers. primary outcome was risk development,...
Mycobacterium avium complex (MAC) and M. abscessus (MABC) comprise the two most important human pathogen groups causing nontuberculous mycobacterial lung disease (NTM-LD). However, there are limited data regarding NTM-LD caused by mixed NTM infections.
Chronic obstructive pulmonary disease (COPD) patients with a body mass index (BMI) < 25 kg/m2 are prone to develop adverse event of pharmacological treatment for frequent exacerbation. As chronic bronchitis (CB) is one the strong risk factors exacerbation, we investigated associations between BMI and COPD exacerbations in CB.Patients were included from Korean Subgroup Study (KOCOSS), multicenter observational cohort study. CB was defined using St. George's Respiratory Questionnaire...
Abstract Background/Aims: Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor stroma. They are primarily associated with maintenance and promotion via diverse mechanisms cancer. Using RNA sequencing, we conducted an analysis aimed at distinguishing distinct markers indicative of CAFs compared to normal (NFs) within context non-small cell lung cancer (NSCLC) across conditions. Methods: We sequencing on 22 11 NFs from patients NSCLC. were isolated cultured tissues (primary or...
A conservative definition of diagnostic yields for assessing the performance guided bronchoscopy has been proposed, but it yet to be validated in practice. Patients who underwent radial endobronchial ultrasound (R-EBUS) between April 2020 and 2023 were included study. Diagnostic results classified as malignant or non-malignant based on post-lung-biopsy pathology. Non-malignant further categorized into specific benign (SB), nonspecific (NSB), atypical cells, non-diagnostic (ND). All lesions...