A5085503132- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Mycobacterium research and diagnosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Lung Cancer Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Lung Cancer Treatments and Mutations
- Eosinophilic Disorders and Syndromes
- Ginseng Biological Effects and Applications
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- Inhalation and Respiratory Drug Delivery
- Health and Wellbeing Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vasculitis and related conditions
- Infectious Diseases and Mycology
- Dysphagia Assessment and Management
- Air Quality and Health Impacts
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Cystic Fibrosis Research Advances
- Artificial Intelligence in Healthcare and Education
- Gut microbiota and health
- Antifungal resistance and susceptibility
Sungkyunkwan University
2018-2025
Samsung Medical Center
2018-2025
Samsung (South Korea)
2022
Universiti Teknologi MARA
2019
Izumi City General Hospital
2019
Korea University
2015
Rationale: Because the prognosis of nontuberculous mycobacterial pulmonary disease varies, a scoring system predicting mortality is needed.Objectives: We aimed to develop novel predict among patients with disease.Methods: included age ≥20 years newly diagnosed disease, Mycobacterium avium, M. intracellulare, abscessus subsp. abscessus, or massiliense. Cox proportional hazards models were used identify predictors in derivation cohort, and was developed. It validated an independent prospective...
The methacholine challenge test (MCT) has high sensitivity but relatively low specificity for asthma diagnosis. This study aimed to develop and validate machine learning (ML) models improve the diagnostic performance of MCT asthma.
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become a standard procedure, but little is known about its infectious complications. The aim of this study to evaluate the incidence and risk factors complications EBUS-TBNA clinical course, including effects on anti-cancer treatment.
Background The role of bacterial microbiota in the pathogenesis nontuberculous mycobacterial pulmonary disease (NTM-PD) is unclear. We aimed to compare microbiome disease-invaded lesions and non-invaded lung tissue from NTM-PD patients. Methods analyzed tissues 23 patients who underwent surgical resection. Lung were collected pairs each patient, with one sample a disease-involved site other non-involved site. libraries constructed using 16S rRNA gene sequences (V3–V4 regions). Results...
Background The concept of treatable traits has been proposed for managing chronic cough; however, evidence supporting its clinical utility remains limited. This study investigated the relationship between baseline and cough persistence in a prospective registry patients with cough. Methods We analyzed data from 426 enrolled Korean Chronic Cough Registry. Eleven potential were assessed at baseline. primary outcome was persistence, defined as severity Visual Analog Scale (VAS) score >20...
Abstract Purpose: Early-stage lung adenocarcinomas (LUADs) manifesting as part-solid radiological features have a slowly progressive course to invasive malignancy, but its genomic alterations and tumor microenvironment are poorly understood. Methods: We analyzed eleven type LUADs from female never-smokers. Whole-exome sequencing whole-transcriptome analysis were conducted on samples seven patients. Single-cell RNA was performed four patients, spatial transcriptomics sample one patient....
Potassium-competitive acid blockers (P-CABs) are a newer class of suppressants with convenient dosing and rapid onset action, while showing efficacy comparable to proton pump inhibitors (PPIs) in treating peptic symptoms gastroesophageal reflux disease (GERD). This study aimed assess the effect P-CABs on GERD-related chronic cough. randomized, double-blind, active-controlled, exploratory trial evaluated adults cough (≥ 8 weeks) recent physician diagnosis GERD or (< 1 month). Participants...
Abstract Background Limited data exist on the treatment outcomes of a two-drug daily regimen macrolide and ethambutol in patients with Mycobacterium avium complex pulmonary disease (MAC-PD). Methods An outcome analysis was performed 108 MAC-PD who underwent at least 12 months macrolides ethambutol. Microbiological responses, antibiotic resistance rates, recurrence rates linked to were analyzed. Results The median overall duration for 13.2 (interquartile range [IQR] 12.1–14.6 months). A total...
Chronic cough (CC) is associated with health-related quality of life (HRQoL) impairment. However, the determinants HRQoL are under-investigated.Patients aged 19-80 years CC were prospectively recruited from 10 referral clinics. Comparisons made age- and sex-matched controls (1:4 ratio) selected a Korean general population survey database; 1) group without current (non-cough controls) 2) another major chronic illnesses (healthy controls). was assessed using EuroQoL 5-dimension (EQ-5D) index....
Abstract Background We evaluated whether the sputum bacterial microbiome differs between nontuberculous mycobacteria pulmonary disease (NTM-PD) patients with stable not requiring antibiotic treatment and those antibiotics. Methods collected samples from 21 clinically NTM-PD (stable group) 14 needing (treatment group). also obtained 13 follow-up group. analyzed 48 using 16S rRNA gene sequencing (V3–V4 region) compared groups. Results In linear discriminant analysis effect size (LEfSe)...
To analyze the characteristics of sputum microbiota patients with nontuberculous mycobacteria pulmonary disease (NTM-PD) based on treatment status. Twenty-eight samples from 14 NTM-PD, including microbiologically cured group (7 at baseline and 7 during follow-up) treatment-refractory were included in this study. Bacterial was analyzed by sequencing V3-V4 region 16S rRNA gene. Among patients, most had infections Mycobacterium avium complex (n = 6), followed abscessus 5); three exhibited mixed...
The chronic obstructive pulmonary disease (COPD) assessment test (CAT) is widely used to assess the impact of COPD symptoms on health status. Whilst CAT consists eight different items, details distribution each item are limited. This study aimed investigate and clinical implication item, stratified by severity group, in stable patients.
This study monitored particulates, and volatile organic compounds (VOCs) emitted from 3-D printers using acrylonitrile-butadiene-styrene copolymer (ABS) filaments at a workplace to assess exposure before after introducing mitigation measures. Air samples were collected in the printing room adjacent corridor, real-time measurements of ultrafine fine particle also conducted. Extensive physicochemical characterizations printer emissions performed, including (size distribution, number...
Current guidelines recommend definitive radiotherapy for patients with medically inoperable early-stage non-small cell lung cancer (NSCLC). However, the impact of underlying pulmonary diseases on survival in those remains unclear.We retrospectively reviewed medical records 234 stage I-II NSCLC treated alone at Samsung Medical Center between January 2010 and October 2017. We compared outcomes according to presence diseases, including chronic obstructive disease (COPD), combined fibrosis...
Globally, a great number of elderly suffer from osteoporosis, especially postmenopausal women. Osteoporosis results in low bone mineral density (BMD) and high risk fragility fracture. However, there is no defined strategy to select the most suitable anti-osteoporotic drugs for osteoporosis patients. Therefore, this study aims effective drug women with osteoporosis.Literature search was conducted PubMed, EMBASE, Cochrane Library. Raw data related randomized clinical trials were extracted. A...
Aspergillus nodules represent a subtype of chronic pulmonary aspergillosis, but details on their characteristics and outcomes are limited. We evaluated 80 patients with pathologically confirmed between January 2009 December 2016. The median age the was 59 years, 46 (58%) were women. Seventy-three (91%) surgically diagnosed remaining seven (9%) by percutaneous transthoracic needle biopsy. long-axis diameter 22 mm, had an internal cavity in 49 (61%) patients. Spiculation calcification observed...
Mycobacterium abscessus pulmonary disease (M abscessus-PD) is challenging to treat because of its resistance antibiotics.What are the outcomes treatment-naive patients with M abscessus-PD treated inhaled amikacin-containing multidrug regimens?We identified 82 from a prospective observational cohort regimens containing amikacin or without clofazimine between March 2015 and June 2018 (ClinicalTrials.gov identifier: NCT00970801). During initial phase, all received IV amikacin, imipenem (or...