A5044955248- HER2/EGFR in Cancer Research
- Biochemical Analysis and Sensing Techniques
- Quinazolinone synthesis and applications
- Neurogenesis and neuroplasticity mechanisms
- Natural product bioactivities and synthesis
- melanin and skin pigmentation
- Drug Transport and Resistance Mechanisms
- Ion Channels and Receptors
- Click Chemistry and Applications
- RNA Interference and Gene Delivery
- PI3K/AKT/mTOR signaling in cancer
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Mast cells and histamine
- NF-κB Signaling Pathways
- Microbial Natural Products and Biosynthesis
- Plant chemical constituents analysis
- Protein Degradation and Inhibitors
- Protease and Inhibitor Mechanisms
- Synthesis of Organic Compounds
- Synthesis and biological activity
- Neurobiology and Insect Physiology Research
- Skin Protection and Aging
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
Chung-Ang University
2016-2025
Korea University
2025
Inha University
2023
Scripps Research Institute
2005-2010
Korea Research Institute of Bioscience and Biotechnology
2009
Jeonbuk National University
2006
Seoul National University
1997-2000
Capsaicin, a pungent ingredient of hot peppers, causes excitation small sensory neurons, and thereby produces severe pain. A nonselective cation channel activated by capsaicin has been identified in neurons cDNA encoding the cloned recently. However, an endogenous activator receptor not yet found. In this study, we show that several products lipoxygenases directly activate capsaicin-activated isolated membrane patches neurons. Among them, 12- 15-( S )-hydroperoxyeicosatetraenoic acids, 5-...
Adult neurogenesis occurs in mammals and provides a mechanism for continuous neural plasticity the brain. However, little is known about molecular mechanisms regulating hippocampal progenitor cells (NPCs) whether their fate can be pharmacologically modulated to improve regeneration. Here, we report characterization of small molecule (KHS101) that selectively induces neuronal differentiation phenotype. Mechanism action studies revealed link KHS101 cell cycle exit specific binding TACC3...
Brain power: An image-based screen of a chemical library was carried out to identify molecules that regulate the differentiation adult rat hippocampal neural stem cells. Neuropathiazol (1) induces selective neuronal and competitively suppresses astrocyte differentiation. This compound should be useful tool study processes control stem-cell fate both in vitro vivo.
Background Individuals with bronchiectasis have an increased risk of exacerbation by coronavirus 2019 (COVID-19), even after recovery from COVID-19. However, the impact COVID-19 severity on severe and mortality remains uncertain. Methods We enrolled 48 342 individuals diagnosed between January 1, 2015 October 7, 2020 Korea National Health Insurance Service. Of these individuals, 2711 were identified as also having recovered A matched cohort (n=2711 for both) established 1:1 propensity...
The bioisosteric analogs exhibited improved cellular activity and microsomal stability, greater HER2 phosphorylation inhibition than lapatinib.
MiRNAs have shown to regulate aging process at the level of cellular senescence, tissue aging, and lifespan whole organism. Given that many miRNAs also function as important regulators hematopoietic system well process, it is highly likely would be involved in changes myeloid differentiation during aging. Therefore, here we examine differential expression aged lineage cells assess if altered miRNA pattern reflect change targets related function. We demonstrated expressions myelogenic such...
In recent years, there has been a dramatic increase in the number and variety of electronic devices that emit electromagnetic waves. Because people live work close proximity to these pieces electrical equipment, is growing concern surrounding destruction homeostasis by field exposure. present study, effects 60 Hz 0.8 mT extremely low-frequency fields (ELF-EMF) on macrophage cell line (RAW 264.7) were examined. Under defined ELF-EMF exposure conditions, production nitric oxide...
Reactive oxygen species (ROS) are involved in a wide range of cellular processes. However, few studies have examined the generation and function ROS human embryonic vascular development. In this study, sources their roles differentiation stem cells (hESCs) were investigated. During hESCs, CD34+ had quiescence-related gene expression profiles large fraction these G0 phase. addition, levels ROS, which primarily generated through NOX4, substantially higher hESC-derived than CD34− cells. To...
Antiangiogenic agents have been widely investigated in combination with standard chemotherapy or targeted cancer for better management of advanced cancers. Therapeutic that concurrently inhibit epidermal growth factor receptor and other angiokinases could be useful alternatives to therapies receptor-dependent Here, we report the synthesis an indole derivative pazopanib using a bioisosteric replacement strategy, which was designated MKP101. MKP101 inhibited not only IC50 value 43 nM but also...
Oxidative stress plays critical roles in airway inflammation that is usually accompanied by increased vascular permeability and plasma exudation. VEGF increases leads to inflammation. In addition, has been shown enhance receptor activator of NF-kappaB (RANK) expression endothelial cells. An aim the study was determine potential role antioxidant regulation RANK murine model asthma. We have used a C57BL/6 mouse allergic asthma evaluate effect L-2-oxothiazolidine-4-carboxylic acid (OTC),...
A novel series of thieno[3,2-d]pyrimidine derivatives were synthesised and their inhibitory effects against diacylglycerol acyltransferase 1 (DGAT-1) assessed. cis-Isomer 17a showed potent selective activity DGAT-1 in SF9 cells. In addition, had an acceptable pharmacokinetic profile accumulated mainly the small intestine liver. Oral administration led to a significant reduction plasma triacylglycerol level during oral lipid tolerance test (OLTT) murine canine models. Taken together, is...
Kraftquelle fürs Gehirn: Durch Screening von Bildern wurde in einer chemischen Bibliothek nach Verbindungen gesucht, die Differenzierung adulter Nervenstammzellen des Rattenhippocampus regeln. Neuropathiazol (1) löst eine selektive neuronale aus und unterdrückt Astrocytendifferenzierung vollständig sollte für Untersuchungen der Prozesse, das Schicksal Stammzellen vitro vivo beeinflussen, nützlich sein.
An essential function of the human epidermis is maintenance a protective barrier against environment. As consequence, keratinocytes, which make up this layer skin, undergo an elaborate process self-renewal, terminal differentiation, and cell death. Misregulation these processes can lead to several diseases, including psoriasis basal squamous carcinomas. To identify novel regulators keratinocyte cell-based screen small-molecule libraries was carried out for molecules that induce...