A5058838920- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Genomic variations and chromosomal abnormalities
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Catalytic C–H Functionalization Methods
- Catalytic Alkyne Reactions
- RNA modifications and cancer
- Catalytic Cross-Coupling Reactions
- Lung Cancer Treatments and Mutations
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Acute Myeloid Leukemia Research
- Ovarian cancer diagnosis and treatment
- Molecular Biology Techniques and Applications
- Chronic Myeloid Leukemia Treatments
- Multiple Myeloma Research and Treatments
- Salmonella and Campylobacter epidemiology
- Retinal Diseases and Treatments
- RNA Research and Splicing
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Zebrafish Biomedical Research Applications
- Immunodeficiency and Autoimmune Disorders
Catholic University of Korea
2016-2025
Hanmi Pharmaceutical (South Korea)
2014-2025
University Hospital Münster
2011-2024
St. Jude Children's Research Hospital
2024
Soonchunhyang University
2022
Weatherford College
2020
Uijeongbu St. Mary's Hospital
2020
Chungnam National University
2006-2018
Ulsan University Hospital
2014-2018
University of Ulsan
2014-2018
Abstract Heart failure (HF) is a frequent consequence of myocardial infarction (MI). Identification the precise, time-dependent composition inflammatory cells may provide clues for establishment new biomarkers and therapeutic approaches targeting post-MI HF. Here, we investigate spatiotemporal dynamics MI-associated immune in mouse model MI using spatial transcriptomics single-cell RNA-sequencing (scRNA-seq). We identify twelve major cell populations; their proportions dynamically change...
The intratumoral heterogeneity (ITH) and the evolution of genomic architectures associated with development distant metastases are not well understood in colorectal cancers.We performed multiregion biopsies primary liver metastatic regions from five cancers whole-exome sequencing copy number profiling.In addition to a substantial level genetic ITH, profiling identifies subclonal mutational architecture, leading region-based or spatial categorization somatic mutations inference evolutionary...
Abstract Uncontrolled oxidative stress impairs bone formation and induces age-related loss in humans. The FoxO family is widely accepted to play an important role protecting diverse cells from reactive oxygen species (ROS). Activation of FoxO1, the main bone, stimulates proliferation differentiation as well inhibits apoptosis osteoblast lineage cells. Despite little known about how FoxO1 expression regulated. Meanwhile, several recent studies reported that microRNAs (miRNAs) could a by...
To evaluate associations of genetic polymorphisms in cytochrome P450 (CYP) isoforms 2D6, 3A5, and 3A4 with blood concentrations hydroxychloroquine (HCQ) its metabolite, N-desethyl HCQ (DHCQ), patients systemic lupus erythematosus (SLE).SLE taking for >3 months were recruited genotyped 4 single-nucleotide CYP2D6*10, CYP3A5*3, CYP3A4*18B. Blood DHCQ ([HCQ] [DHCQ]) measured their association corresponding genotypes was investigated.A total 194 included the analysis. CYP2D6*10 (rs1065852...
Abstract Predicting the risk of metastasis before starting prostate cancer (PCa) treatment can minimize overtreatment indolent cases and help choosing appropriate treatment. The levels circulating microRNAs (miRNAs) from body fluids be used as noninvasive prognostic biomarkers. In this study, urinary exosomal miRNA expression profiles 149 PCas were determined miRNAs associated with identified: miR-21, miR-16, miR-142-3p, miR-451, miR-636. When evaluating clinical factors together, miR-636,...
The insulation of axons in the vertebrate nervous system by myelin is essential for efficient axonal conduction. Myelination disruption and remyelination failure can cause human diseases, such as multiple sclerosis hereditary diseases. However, despite progress understanding myelination regulation, many important questions remain unanswered. To investigate mechanisms underlying vivo, we generated transgenic zebrafish expressing enhanced green fluorescent protein (EGFP) under control mbp...
// Seung-Hyun Jung 1, 3 , Min Sung Kim 2 Chan Kwon 4 Hyun-Chun Park So Youn Jieying Liu Ja-Seong Bae 5 Hak Lee Tae-Min 6 Sug Hyung Yeun-Jun Chung 1 Department of Microbiology, College Medicine, The Catholic University Korea, Seoul, Korea Pathology, Integrated Research Center for Genome Polymorphism, Hospital General Surgery, Medical Informatics, Correspondence to: Chung, email: yejun@catholic.ac.kr Lee, suhulee@catholic.ac.kr Keywords: follicular thyroid adenoma, carcinoma, mutations, copy...
// Shinn Young Kim 1, 3, * , Seung-Hyun Jung Min Sung 2 In-Pyo Baek 3 Hak Lee 4 Tae-Min 5 Yeun-Jun Chung Sug Hyung 1 Department of Microbiology, The Catholic University Korea, Seoul Pathology, Integrated Research Center for Genome Polymorphism, Hospital Medical Informatics, College Medicine, These authors have contributed equally to this work Correspondence to: Chung, e-mail: yejun@catholic.ac.kr Lee, suhulee@catholic.ac.kr Keywords: breast cancer, ductal carcinoma in situ genomic...
Although hypomethylating therapy (HMT) is the first line in higher-risk myelodysplastic syndromes (MDS), predicting response to HMT remains an unresolved issue. We aimed identify mutations associated with and survival MDS. A total of 107 Korean patients MDS who underwent (57 responders 50 non-responders) were enrolled. Targeted deep sequencing (median depth coverage 1,623X) was performed for 26 candidate genes. In multivariate analysis, no mutation significantly HMT, but a lower hemoglobin...
Recent discovery of the copy number variation (CNV) in normal individuals has widened our understanding genomic variation. However, most reported CNVs have been identified Caucasians, which may not be directly applicable to people different ethnicities. To profile CNV East-Asian population, we screened 3578 healthy, unrelated Korean individuals, using Affymetrix Genome-Wide Human SNP array 5.0. We 144,207 a pooled data set 100 randomly chosen females as reference. The average per genome was...
Sox11 deletion mice are known to exhibit developmental defects of craniofacial skeletal malformations, asplenia, and hypoplasia the lung, stomach, pancreas. Despite importance in developing skeleton, role osteogenesis has not been studied yet. In this study, we identified that is an important transcription factor for regulating proliferation survival osteoblast precursor cells as well self-renewal potency mesenchymal progenitor via up-regulation Tead2. Furthermore, also plays segregation...
Although it has been suggested that kinesin family member 14 (KIF14) oncogenic potential in various cancers, including hepatocellular carcinoma (HCC), the molecular mechanism of this remains unknown. We aimed to elucidate role KIF14 hepatocarcinogenesis by knocking down HCC cells overexpressed KIF14. After knockdown, changes tumor cell growth, cycle and cytokinesis were examined. also examined regulatory molecules upstream Skp1/Cul1/F-box (SCF) complex molecules. Knockdown resulted...
Vulvar squamous cell carcinoma (SCC) consists of two different etiologic categories: human papilloma virus (HPV)-associated (HPV (+)) and HPV-non-associated (−)). There have been no genome-wide studies on the genetic alterations vulvar SCCs or differences between HPV (+) (−) SCCs. In this study, we performed whole-exome sequencing copy number profiling 6 9 found known mutations (TP53, CDKN2A HRAS) (CNAs) (7p 8q gains 2q loss) in (+), novel PIK3CA, BRCA2 FBXW7 that had not reported exhibited...
Background and Purpose Although a variety of animal models have been used to test drug candidates examine the pathogenesis diabetic retinopathy, time‐saving inexpensive are still needed evaluate increasing number therapeutic approaches. Experimental Approach We developed model for retinopathy using early stage transgenic zebrafish ( flk :EGFP) by treating embryos with 130 mM glucose, from 3‐6 days post fertilisation (high‐glucose model). On day 6, lenses larvae were isolated treated 3%...
Intratumoural heterogeneity (ITH) leads to regional biases of the mutational landscape in a single tumour and may influence biopsy-based clinical diagnosis treatment decision. To evaluate extent ITH unifocal prostate cancers (PCAs), we analysed multiple biopsies from three PCAs, using whole-exome sequencing, DNA copy number gene expression profiling analyses. A substantial level was identified, that 0-61% 18-71% somatic variants were common or private, respectively, within given cancer. The...
In Young Yoo, M.D., Ph.D., Joo An Kwon, M.T., Miran Lee, Seung-Hyun Jung, Jung Ok Kim, M.S., Sung Il Ha, and Yeon-Joon Park, Ph.D.. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2023.0430
Significance This report is an in-depth genetic profiling of pulmonary sclerosing hemangioma (PSH). We have discovered that PSH harbor recurrent AKT1 mutations (45.6%), most which were p.E17K mutations. mutation may be the single-most common driver alteration to develop PSHs. In contrast lung adenocarcinoma, genomes only a single ( or β-catenin ), provide clues understanding benign biology and for differential genomic diagnosis tumors.
Significance Emotion-related responses, such as fear and anxiety, are important behavioral phenomena in most animal species, well humans. However, the underlying mechanisms of anxiety animals humans still largely unknown, disorders continue to represent a large unmet medical need human clinic. Animal models may speed up discovery these also lead betterment health. Herein, we report identification chemokine-like gene family, samdori ( sam ), present functional characterization sam2 . We...
Although high grade prostatic intraepithelial neoplasia (HGPIN) is considered a neoplastic lesion that precedes prostate cancer (PCA), the genomic structures of HGPIN remain unknown.Identification landscape and differences between PCA may drive progression to PCA.We analyzed 20 regions paired from six patients using whole-exome sequencing array-comparative hybridization.Somatic mutation copy number alteration (CNA) profiles were measured compared.The total mutations CNAs HGPINs significantly...
Background: Although most differentiated thyroid carcinomas (DTCs) have indolent behavior, DTCs with distant metastasis a poor prognosis. However, there are no validated markers that predict the risk of and prognosis DTC. We aimed to develop genetic classifier for predicting outcomes DTC patients metastases. Methods: Targeted deep sequencing 157 cancer-related genes was performed 61 A candidate mutation independent cancer samples using digital polymerase chain reaction. Results: The...