A5091529546- Cystic Fibrosis Research Advances
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diagnosis and treatment of tuberculosis
- Dysphagia Assessment and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Mycology
- Pediatric health and respiratory diseases
- Infectious Diseases and Tuberculosis
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Esophageal and GI Pathology
- Respiratory viral infections research
- Liver Disease Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Health and Wellbeing Research
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Clinical Research Studies
- Gastroesophageal reflux and treatments
- Cancer-related molecular mechanisms research
Chungbuk National University Hospital
2020-2025
National University College
2022-2025
New Generation University College
2022-2025
Chungbuk National University
2021-2024
Zero to Three
2021-2024
Hanyang University
2023
Korea University
2023
Korea University Medical Center
2023
National Cancer Center
2019-2021
Chinese People's Liberation Army
2021
Patients with lung disease caused by Mycobacterium abscessus subsp. (here M. abscessus) typically have poor treatment outcomes. Although clofazimine (CFZ) has been increasingly used in the of clinical practice, there are no reported data on its effectiveness for this disease. This study sought to evaluate efficacy a CFZ-containing regimen We performed retrospective review medical records 42 patients who were treated regimens between November 2013 and January 2015. CFZ was administered...
Background There are limited data regarding the relationship between interstitial lung disease (ILD) and natural course of COVID-19. In this study, we investigate whether patients with ILD more susceptible to COVID-19 than those without evaluate impact on severity in Methods A nationwide cohort (n=8070) a 1:15 age-, sex- residential area-matched (n=121 050) were constructed 1 January 2020 30 May Korea. We performed nested case–control study compare proportions matched cohort. Using cohort,...
Abstract There are limited data regarding whether mortality is higher in patients with non cystic fibrosis bronchiectasis (bronchiectasis) than those without bronchiectasis. Using 2005–2015 from the Korean National Health Insurance Service, we evaluated hazard ratio (HR) for all-cause cohort relative to matched cohort. The effect of comorbidities over study period on was also assessed. All-cause significantly (2505/100,000 vs 2142/100,000 person-years, respectively; P < 0.001). Mortality...
Rationale: It remains unclear whether non-cystic fibrosis bronchiectasis increases the risk of lung cancer, because smoking history was not considered in previous studies. Objectives: To evaluate participants with have a higher incident cancer than those without information on status. Methods: This population-based cohort study 3,858,422 individuals who participated 2009 National Health Screening Program. We evaluated incidence (n = 65,305) and 3,793,117). followed up until date diagnosis,...
The association between systemic sclerosis and the development of bronchiectasis is unclear. This study aimed to compare risk individuals with those without using a nationwide longitudinal dataset.Using Korean National Health Insurance Service dataset 2010 2017, we identified 4845 aged ≥ 20 years 24,225 who were matched 1:5 by age sex. They followed up until date diagnosis, death, or December 31, 2019, whichever came first.During median follow-up period 6.0 (interquartile range, 3.2-8.7)...
Introduction Studies that comprehensively evaluate the association between physical activity (PA) levels, particularly by quantifying PA intensity, and healthcare use requiring emergency department (ED) visit or hospitalisation in patients with chronic obstructive pulmonary disease (COPD) are limited Korea. Methods The risk of all-cause respiratory ED according to presence absence COPD level was evaluated a retrospective nationwide cohort comprising 3308 subjects (COPD cohort) 293 358...
ABSTRACT Although guidelines recommend amikacin (AMK) inhalation therapy for difficult-to-treat nontuberculous mycobacterial lung disease (NTM-LD), data are limited regarding the safety and clinical efficacy of this salvage therapy. We retrospectively evaluated treatment outcomes 77 patients with refractory NTM-LD caused by Mycobacterium abscessus complex (MABC) or M. avium (MAC) who initiated AMK between February 2015 June 2016. MABC was most common etiology ( n = 48, 62%), followed MAC 20,...
Although remimazolam is an ultra-short-acting benzodiazepine with a shorter elimination half-life and faster recovery time than midazolam, studies evaluating its safety efficacy during bronchoscopy are limited. This study aimed to compare the of those midazolam for bronchoscopy. prospective randomized parallel-group was conducted at single institution. The primary outcome from end procedure full alertness. Other procedural parameters, satisfaction profiles, adverse effects were thoroughly...
Poor nutrition increases disease severity and mortality in patients with tuberculosis (TB). There are gaps our understanding of the effects being underweight or overweight on TB relation to sex.We generated a nationwide registry database assessed body mass index (BMI) pulmonary TB. The cause death was further classified as TB-related non-TB-related deaths. First, logistic regression analysis performed assess association between BMI (a continuous variable) mortality, subgroup analyses...
Background Individuals with bronchiectasis have an increased risk of exacerbation by coronavirus 2019 (COVID-19), even after recovery from COVID-19. However, the impact COVID-19 severity on severe and mortality remains uncertain. Methods We enrolled 48 342 individuals diagnosed between January 1, 2015 October 7, 2020 Korea National Health Insurance Service. Of these individuals, 2711 were identified as also having recovered A matched cohort (n=2711 for both) established 1:1 propensity...
Little information is available regarding whether active physical activity lowers mortality risk in individuals with bronchiectasis. We used the Korean National Health Insurance Service database from 2010 to 2016 evaluate association between changes and Of 552,510 newly diagnosed bronchiectasis, we enrolled 165,842 who had two consecutive health examinations before after bronchiectasis diagnosis, within years, as study aimed measure exercise habits time points. Active was defined engaging...
Abstract Background Screening patients with asymptomatic active tuberculosis (TB) is crucial as they can transmit the disease. Identifying risk factors for transmission essential targeted screening. Understanding how infectiousness of TB affects disease outcomes developing strategies to control spread. Methods We analyzed national Korean cohort data determine associated and clinical in pulmonary TB. The primary outcome was a factor transmission, while secondary mortality stratified by risk....
There are conflicting results regarding endogenous estrogen exposure and risk of incident nontuberculous mycobacterial pulmonary disease (NTM-PD). In addition, evidence on impact hormone replacement therapy (HRT) NTM-PD is lacking. This study aimed to evaluate the impacts HRT in postmenopausal women.This population-based cohort comprised 1 400 095 women without previous who participated 2009 national health screening exam South Korea. The was followed until date NTM-PD, death, or December...
Introduction Despite the significant disease burden of bronchiectasis in Korea, no large-scale, representative prospective cohort studies have been conducted to evaluate clinical characteristics Korean patients with bronchiectasis, indicating an urgent need for on bronchiectasis. Methods and analysis The Multicenter Bronchiectasis Audit Research Collaboration (KMBARC) is a prospective, non-interventional observational study Korea. inclusion criteria this registry are as follows: (1) adult...
Tuberculosis (TB) is a major cause of ill health and one the leading causes death worldwide. The first step in developing strategies to reduce TB mortality identify direct patients with risk factors for each cause.Data on systemically collected from National Surveillance System South Korea January 2019 December 2020 were included this study. We analyzed clinical characteristics associated non-TB-related deaths, including TB-related symptoms, comorbidities, radiographic microbiological...
Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD). This study assessed the COPD development and COPD-related hospitalization in TB compared to controls.
The prevalence and disease burden of bronchiectasis in comparison to those chronic obstructive pulmonary (COPD) have not been well elucidated using a nationally representative database.We compared respiratory symptoms, physical activity, quality life, socioeconomic status subjects with versus COPD or control participating the Korea National Health Nutrition Examination Survey 2007-2009. Participants were classified as physician-diagnosed bronchiectasis, COPD, (those without...