A5028955760- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cell death mechanisms and regulation
- Respiratory and Cough-Related Research
- Natural Compounds in Disease Treatment
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Infectious Encephalopathies and Encephalitis
- Cytokine Signaling Pathways and Interactions
- COVID-19 Clinical Research Studies
- Medical Imaging and Pathology Studies
- Cardiac tumors and thrombi
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- Bacterial Infections and Vaccines
- Alcoholism and Thiamine Deficiency
- Venous Thromboembolism Diagnosis and Management
- Biochemical Acid Research Studies
Dankook University
2015-2025
Dankook University Hospital
2008-2022
The Korean Academy of Tuberculosis and Respiratory Diseases
2010
Sangji University
2006
Colorado State University
2005
Seoul National University
1998
The increasing worldwide incidence of extensively drug-resistant tuberculosis (XDR-TB) has emerged as a threat to public health and (TB) control. Treatment outcomes have varied among studies, data on long-term survival are still scarce.To retrospectively assess the burden, clinical characteristics, treatment outcomes, rate patients with XDR-TB in cohort HIV-negative multidrug-resistant (MDR-TB) South Korea.Medical records were reviewed newly diagnosed or retreated for MDR-TB from 2000 2002....
In this study, we investigated the ability of four clinical isolates Mycobacterium tuberculosis representing a range virulence for their capacity to grow in bone marrow-derived macrophages. The rate growth each macrophages reflected known virulence, but most virulent strongly induced production cytokine tumor necrosis factor alpha. A key difference, however, was degree cell cytotoxicity observed with more strains after several days culture. Staining monolayers DNA fragmentation indicative...
Rationale: Few large-scale studies have investigated multidrug-resistant tuberculosis (MDR-TB) treatment outcomes relative to drug-resistance patterns.Objectives: To assess the impact of additional drug resistances on and long-term survival in a large HIV-negative MDR-TB cohort.Methods: Treatment patients with newly diagnosed or retreated 2000 2002 were retrospectively analyzed based patterns after 5–8 years follow-up.Measurements Main Results: Of 1,407 MDR-TB, 75 (5.3%) had extensively...
TNF-related apoptosis-inducing ligand (TRAIL/Apo- 2L), a newly identified member of the TNF family promotes apoptosis by binding to transmembrane receptors (TRAIL-R1/DR4 and TRAIL-R2/ DR5). TRAIL known activate NF-κB in number tumor cells including A549 (wt p53) NCI- H1299 (null lung cancer exerts relatively selective cytotoxic affects human cell lines without much effect on normal cells. We set out identify an agent that would sensitize TRAIL-induced through inhibition activation. found...
<b><i>Background:</i></b> Few studies have investigated the impact of diabetes mellitus (DM), a globally increasing metabolic disease, on treatment outcomes and long-term survival in patients with multidrug-resistant forms tuberculosis (MDR-TB). <b><i>Objectives:</i></b> We analyzed large cohort to assess DM MDR-TB. <b><i>Methods:</i></b> MDR-TB newly diagnosed or retreated between 2000 2002 followed for 8-11 years were...
Abstract Disparities exist between sexes regarding tuberculosis (TB) incidence, as well disease severity and outcome. Using a nationwide TB registry database, we explored the impact of sex age on extrapulmonary (EPTB) among all enrolled patients by (1) calculating female proportion for every category according to TB-affected locations, (2) proportions EPTB stratified age, (3) conducting multivariable analysis examine likelihood, (4) assessing odds compared male reference in category....
Poor nutrition increases disease severity and mortality in patients with tuberculosis (TB). There are gaps our understanding of the effects being underweight or overweight on TB relation to sex.We generated a nationwide registry database assessed body mass index (BMI) pulmonary TB. The cause death was further classified as TB-related non-TB-related deaths. First, logistic regression analysis performed assess association between BMI (a continuous variable) mortality, subgroup analyses...
Patients with tuberculosis and diabetes have a higher risk of unfavourable anti-tuberculosis treatment outcomes. In the present study, we aimed to evaluate effects various statuses on outcomes patients pulmonary tuberculosis.
Abstract Background Screening patients with asymptomatic active tuberculosis (TB) is crucial as they can transmit the disease. Identifying risk factors for transmission essential targeted screening. Understanding how infectiousness of TB affects disease outcomes developing strategies to control spread. Methods We analyzed national Korean cohort data determine associated and clinical in pulmonary TB. The primary outcome was a factor transmission, while secondary mortality stratified by risk....
We investigated the prevalence of latent tuberculosis infection (LTBI) among health care workers (HCWs) and analyzed its risk factors in South Korea.A standard questionnaire regarding baseline demographics for LTBI was given to each participant tuberculin skin test (TST), QuantiFERON-TB GOLD In-Tube (QFT-GIT) assay, chest radiography were performed.A total 493 participants, 152 (30.8%) doctors 341 (69.2%) nurses enrolled eight tertiary referral hospitals. The mean age subjects 30.6 years...
The national Public-Private Mix (PPM) tuberculosis (TB) control project provides for the comprehensive management of TB patients at private hospitals in South Korea. Surveillance and monitoring under PPM are essential toward achieving elimination goals.TB is a nationally notifiable disease Korea monitored using surveillance system. Centers Disease Control Prevention quarterly generates indicators management, used to evaluate activities by central steering committee project. Based on...
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic caused disruptions to healthcare systems and endangered the control prevention of tuberculosis (TB). We investigated nationwide effects COVID-19 on national Public-Private Mix (PPM) TB project in Korea, using monitoring indicators from Korean PPM database. METHODS: database includes data patients registered at hospitals throughout country. Data six for active cases updated between July June 2020 were collected. each cohort country...
Tuberculosis (TB) is a major cause of ill health and one the leading causes death worldwide. The first step in developing strategies to reduce TB mortality identify direct patients with risk factors for each cause.Data on systemically collected from National Surveillance System South Korea January 2019 December 2020 were included this study. We analyzed clinical characteristics associated non-TB-related deaths, including TB-related symptoms, comorbidities, radiographic microbiological...
Although the incidence of tuberculosis (TB) has decreased in South Korea, mortality rate remains high. TB is a key indicator for control interventions. The purpose this study was to assess early and TB-related during anti-TB treatment describe associated clinical characteristics.A multicenter cross-sectional performed across Korea. Patients with pulmonary who died whose records were submitted national surveillance system between 2015 2017 enrolled. All deaths categorized based on cause...
The coronavirus disease 2019 (COVID-19) pandemic caused disruptions to healthcare systems, consequently endangering tuberculosis (TB) control. We investigated delays in TB treatment among notified patients during the first wave of COVID-19 Korea.We systemically collected and analyzed data from Korea cohort database January May 2020. Groups were categorized as 'before-pandemic' 'during-pandemic' based on notification period. Presentation delay was defined period between initial onset symptoms...
Epidemiological data of Bordetella pertussis infection among adolescents and adults are limited in Korea. Patients (≥ 11 yr age) with a bothersome cough for less than 30 days were enrolled during 1-yr period at 22 hospitals Nasopharyngeal swabs collected polymerase chain reaction (PCR) bacteriologic culture. In total, 490 patients finally enrolled, 34 (6.9%) tested positive B. pertussis; duration (14.0 [7.0-21.0 days]) age distribution diverse. The incidence was the highest secondary...
Background The risk of tuberculosis (TB) infection among health care workers (HCWs) is higher than as noted in the general population. prevalence and factors TB HCWs were assessed a tertiary hospital South Korea, resulting conclusion an intermediate burden within country. Methods This cross-sectional study enrolled who underwent QuantiFERON-TB Gold In-Tube (QFT-GIT) test to detect presence latent (LTBI), patients admitted Korea 2017. departments divided into TB-related TB-unrelated...
The Government of South Korea launched a national preemptive latent tuberculosis infection (LTBI) screening program in 2016, including more than 1. 6 million population congregate settings. objective this study was to analyze LTBI prevalence and its risk factors each setting. Additionally, the proportion pool covered by current strategy investigated. Database for results interferon gamma release assay (IGRA), X-ray, baseline demographic information linked with National Health Information...
Treatment success rates of multidrug-resistant tuberculosis (MDR-TB) remain unsatisfactory, and long-term use second-line anti-TB drugs is accompanied by the frequent occurrence adverse events, low treatment compliance, high costs. The development new efficient regimens with shorter durations for MDR-TB will solve these issues improve outcomes. This study a phase II/III, multicenter, randomized, open-label clinical trial non-inferiority design comparing regimen to World Health...
Pathologic findings of scrub typhus have been characterized by vasculitis the microvasculature involved organ resulting from a direct invasion Orientia tsutsugamushi. We experienced case acute respiratory distress syndrome (ARDS) associated with typhus. The was proven eschar and high titer serum IgM antibody (positive at 1:1280). Open lung biopsy showed diffuse alveolar damage (DAD) in organizing stage without evidence vasculitis. Immunofluorescent staining polymerase chain reaction for O....
Background: Stopping medical treatment by tuberculosis (TB) patients prior to completing period is a major concern in private hospitals.We evaluated the impact of public-private mix (PPM) project on increasing success rate TB tertiary hospital Korea.Methods: Starting February 2009, treated at Dankook University Hospital received health education and case monitoring activities specially trained public nurses (PPM project).On retrospective basis, we reviewed records compared outcome under PPM...
Abstract Tuberculosis (TB) has a heterogeneous phenotype, which makes it challenging to diagnose. Our study aimed identify TB phenotypes through cluster analysis and compare their initial symptomatic, microbiological radiographic characteristics. We systemically collected data of notified patients in Korea constructed prospective, observational cohort database. Cluster was performed using K-means clustering, the variables be included were determined by correlation network. A total 4,370...
In South Korea, public-private mix (PPM) was launched in 2011. This retrospective cohort study sought to determine the rate of loss follow-up (LTFU) among drug-susceptible tuberculosis (DS-TB) patients all nationwide PPM institutions, and risk factors for LTFU. National notification data DS-TB diagnosed between August 2011 July 2014 institutions were analysed. Determination LTFU included detection instances where transferred out, but when they did not attend at other TB centres following two...