A5102992569- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Tuberculosis Research and Epidemiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pleural and Pulmonary Diseases
- Lung Cancer Research Studies
- Respiratory Support and Mechanisms
- Particle accelerators and beam dynamics
- Superconducting Materials and Applications
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Sepsis Diagnosis and Treatment
- Tracheal and airway disorders
- Radiomics and Machine Learning in Medical Imaging
- Nosocomial Infections in ICU
- Medical Imaging and Pathology Studies
- Health and Wellbeing Research
- Infectious Diseases and Tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Health, psychology, and well-being
- Cancer Immunotherapy and Biomarkers
Pusan National University Hospital
2014-2024
Pusan National University
2015-2024
Institute for Basic Science
2014-2024
Weatherford College
2021
Inje University Seoul Paik Hospital
2021
Busan National University of Education
2019
Pulmonary and Allergy Associates
2019
Korea University
2017
Korea University Medical Center
2017
Rural Development Administration
2016
Widely distributed in plants, flavonoids reduce the incidence of cancer and cardiovascular disease. In this study, flavonoid content composition members Prunus genus were evaluated using liquid chromatography with diode array electrospray ionization mass spectrometric detection (UPLC-DAD-ESI/QTOF-MS). Flavonoids plants include basic structures kaempferol, quercetin, catechin, exist as mono-, di-, or tri-glycoside compounds mono-acylated acetic acid. A total 23 individual isolated confirmed,...
To evaluate the efficacy of combined vitamin C, hydrocortisone, and thiamine in patients with severe pneumonia.All consecutive pneumonia who were treated C protocol (6 g per day) June 2017-January 2018 (n = 53) compared to all 2016-January 2017 46). Propensity score analysis was used adjust for potential baseline differences between groups.In propensity-matched cohort 36/group), had significantly less hospital mortality than control group (17% vs. 39%; P 0.04). The associated independently...
Abstract Background Pulmonary actinomycosis is a chronic pulmonary infection caused by Actinomyces . Both improving oral hygiene and early application of antibiotics to the case suspicious infections result in changes incidences presentations actinomycosis. However, there are little reports dealt with recent clinical characteristics This study aimed review occurred during first decade 21st century. Methods retrospective was performed on 94 subjects diagnosed pathologically from January 2000...
Epidermal growth factor receptor (EGFR)-activating mutations are major determinants in predicting the tumor response to EGFR tyrosine kinase inhibitors non-small cell lung cancer (NSCLC). Noninvasive test for detection of is required, especially NSCLC patients from whom tissue not available. In this study, we assessed feasibility free DNA circulating plasma.Plasma samples 60 with partial gefitinib were analyzed detect EGFR-activating exons 19 and 21. Forty (66.7%) had mutation results....
Abstract Background The tumor-associated calcium signal transducer ( TACSTD ) genes, originally designated epithelial cell adhesion molecule (EpCAM) and TROP2, represent true oncogenes. Little is known about EpCAM TROP2 gene expression in non-small lung carcinoma (NSCLC). This study evaluated protein clinicopathologic significance cases of NSCLC. Methods Tissue microarray blocks acquired from 164 NSCLC, including 100 adenocarcinoma (AdC) 64 squamous (SCC), were examined by...
ObjectivesIn the LUX-Lung clinical trials of afatinib in EGFR mutation-positive NSCLC, tolerability-guided dose adjustment reduced incidence and severity adverse events while maintaining efficacy. The RealGiDo study evaluated impact a real-world setting.Materials methodsThis non-interventional, observational used medical records NSCLC patients treated with first-line afatinib. Primary outcomes were drug reaction (ADR) severity, time to treatment failure (TTF), progression (TTP), relative 3...
Background Low‐dose computed tomography can identify smaller nodules more often than chest radiography in lung screening. However, complications from invasive diagnostic procedures performed to detect are common. Exosomes contain a diverse array of biomolecules that reflect the biological state cell which they released. The aim this study was investigate value bronchoalveolar lavage (BAL) fluid exosomal microRNAs (miRNAs) for early‐stage adenocarcinoma. Methods We evaluated miRNAs (miR‐7,...
To reduce lung cancer mortality, screening was recommended using low-dose computed tomography (LDCT) to high-risk population. A protocol for multicenter pilot project developed evaluate the effectiveness and feasibility of implement National Cancer Screening Program in Korea.Multidisciplinary expert committee comprised develop a standardized Korean Lung Project (K-LUCAS). K-LUCAS is population-based single arm trial that targets population aged 55-74 years with at least 30 pack-year smoking...
Despite the obvious benefits of adding immune checkpoint inhibitors to platinum-etoposide chemotherapy in patients with extensive-stage small-cell lung cancer (ES-SCLC), real-world data remain scarce.This retrospective study included 89 ES-SCLC treated alone (chemo-only group; n = 48) or combination atezolizumab (atezolizumab 41) and compared survival outcomes between these two groups.Overall (OS) was significantly longer group than chemo-only (15.2 months vs. 8.5 months; p 0.047), whereas...
Purpose There have been efforts to find alternative samples other than standard of tissue or plasma for mutational analyses lung cancer patients. However, no sample technique has replaced the using samples. In this prospective study, we assessed a novel bronchoscopy method, named as targeted washing technique, detecting EGFR mutation. Materials and Methods A 3.0-mm ultrathin bronchoscope was precisely navigated target lesion with assistance virtual bronchoscopic navigation fluoroscopy. Once...
Bcr-Abl-independent signaling pathways are known to be involved in imatinib resistance some patients with chronic myelogenous leukemia (CML). In this study, find new targets for imatinib-resistant CML displaying loss of Bcr-Abl kinase target dependence, we isolated variants, K562/R1, K562/R2, and K562/R3, which showed profound declines levels its tyrosine activity, from K562 cells. Importantly, the mechanism these variants also included aberrant acetylation nonhistone proteins such as p53,...
Abstract Background: Lung cancer is a leading cause of deaths. Unfortunately, no effective early screening modality exists for lung cancer. We aimed to evaluate the prevalence HOXA9 promoter methylation in tissue and induced sputum samples from Korean patients with Methods: Using pyrosequencing, was analyzed 40 pairs primary normal tissues 185 specimens, including 76 Results: The significantly higher compared (67.4%±17.6% vs. 23.6%±10.3%, respectively; p<0.001). With cut-off >45.6%...
Light emitting diode (LED) lights play an important role in the plant physiology and alter metabolites a significant manner. Glucosinolates (GSLs), polyphenols, flavonoids antioxidant properties of Chinese cabbage kale cultivated varying LED were investigated. Analysis revealed 7 aliphatic, 3 indolyl 1 aromatic GSLs kale. The total GSL content ranged from 1.5-19.08 1.85-24.87 µmol/g DW, glucobrassicanapin was predominant (3) cabbage, whereas; sinigrin (3.49 DW) Blue red produced...
REarranged during Transfection (RET) fusion genes are detected in approximately 1% of lung adenocarcinomas and known primarily as oncogenic driver factors. Here, we found a novel RET gene, KIAA1217-RET, examined the functional differences RET51 RET9 protein, fused with KIAA1217 cancer progression drug response. resulting from rearrangement chromosome 10, was generated by exon 11 non-small cell patient. Expression this gene led to increased growth invasive properties through activations...
The diagnostic yield of transbronchial biopsy (TBB) using radial probe endobronchial ultrasound (RP-EBUS) is 71%, which lower than that transthoracic needle biopsy. We investigated the performance and safety sequential cryobiopsy (TBC) a novel 1.1-mm diameter cryoprobe, after conventional TBB RP-EBUS for diagnosis peripheral lung lesions (PLLs).From April 2021 to November 2021, 110 patients who underwent bronchoscopy PLL ≤ 30 mm were retrospectively included in our study. All records...
Tuberculosis (TB) is a major cause of ill health and one the leading causes death worldwide. The first step in developing strategies to reduce TB mortality identify direct patients with risk factors for each cause.Data on systemically collected from National Surveillance System South Korea January 2019 December 2020 were included this study. We analyzed clinical characteristics associated non-TB-related deaths, including TB-related symptoms, comorbidities, radiographic microbiological...
Real-world data on the use and outcomes of crizotinib in ROS1-rearranged non-small-cell lung cancer (NSCLC) are limited. This study aims to analyze real-world efficacy South Korea explore utilization liquid biopsies that implement next-generation sequencing (NGS) using cell-free total nucleic acids. In this prospective multicenter cohort study, 40 patients with NSCLC, either starting or already crizotinib, were enrolled. Patients had a median age 61 years, 32.5% presenting brain/central...