A5101969972- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Tuberculosis Research and Epidemiology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Infectious Diseases and Tuberculosis
- Ferroptosis and cancer prognosis
- Diverse Approaches in Healthcare and Education Studies
- Cytomegalovirus and herpesvirus research
- Renal and related cancers
- Fungal Biology and Applications
- melanin and skin pigmentation
- Medical Imaging and Pathology Studies
- Viral-associated cancers and disorders
- Antibiotic Resistance in Bacteria
- Respiratory Support and Mechanisms
- Systemic Sclerosis and Related Diseases
- Cell death mechanisms and regulation
- Inhalation and Respiratory Drug Delivery
- Tracheal and airway disorders
- Cancer-related molecular mechanisms research
Inje University Busan Paik Hospital
2016-2025
Kyungpook National University
2014-2024
Tokai University
2024
Animal and Plant Quarantine Agency
2023
Kyungpook National University Hospital
2023
Korea Association of Health Promotion
2021-2022
National Cancer Institute
2021-2022
National Institutes of Health
2022
Center for Cancer Research
2022
Chuncheon Sacred Heart Hospital
2021
Experts disagree about the causes and significance of recent increases in prevalence autism spectrum disorders (ASDs). Limited data on population base rates contribute to this uncertainty. Using a population-based sample, authors sought estimate describe clinical characteristics ASDs school-age children.The target was all 7- 12-year-old children (N=55,266) South Korean community; study used high-probability group from special education schools disability registry low-probability,...
Current treatments for idiopathic pulmonary fibrosis slow the rate of lung function decline, but may be associated with adverse events that affect medication adherence. In phase 2 trials, pamrevlumab (a fully human monoclonal antibody binds to and inhibits connective tissue growth factor activity) attenuated progression without substantial events.
Epidermal growth factor receptor (EGFR)-activating mutations are major determinants in predicting the tumor response to EGFR tyrosine kinase inhibitors non-small cell lung cancer (NSCLC). Noninvasive test for detection of is required, especially NSCLC patients from whom tissue not available. In this study, we assessed feasibility free DNA circulating plasma.Plasma samples 60 with partial gefitinib were analyzed detect EGFR-activating exons 19 and 21. Forty (66.7%) had mutation results....
During our on-going attempts to develop a new skin-whitening agent, we identified novel candidate compound KHG22394, 2-imino-1,3-thiazoline derivative. Our data show that KHG22394 significantly inhibits melanin production in dose-dependent manner, but it does not directly inhibit tyrosinase, the rate limiting melanogenic enzyme. It has been reported activation of extracellular signal-regulated kinase (ERK) reduces synthesis by downregulating microphthalmia-associated transcription factor...
Sorafenib (SRF) is a multi-kinase inhibitor that has been shown to have antitumor activity against several types of cancers, but the effect SRF on EBV-transformed B cells unknown. We report can induce apoptosis through JNK/p38-MAPK activation. triggered generation reactive oxygen species (ROS), translocation Bax into mitochondria, disruption mitochondrial membrane potential, activation caspase-9, caspase-3 and PARP, subsequent apoptosis. Moreover, we found exposure activated phosphorylation...
Ginsenoside Rh2 has been known to enhance the activity of immune cells, as well inhibit growth tumor cells. Although repertoire genes regulated by is well-known in many cancer epigenetic regulation yet be determined, especially for comprehensive approaches detect methylation changes. The effect on genome-wide DNA changes breast cells was examined treating cultured MCF-7 with Rh2. Pyrosequencing analysis carried out measure level a global marker, LINE1. Genome-wide identify epigenetically and...
Abstract Proteins localized to various cellular and subcellular membranes play pivotal roles in numerous activities. Accordingly, eukaryotic cells, the biogenesis of organellar proteins is an essential process requiring their correct localization among membranes. Localization these determined by either cotranslational or posttranslational mechanisms, depending on final destination. However, it not fully understood how targeting specificity membrane plant cells. Here, we investigate mechanism...
Cold atmospheric plasma (plasma) has emerged as a novel tool for cancer treatment option, having been successfully applied to few types of cells, well tissues. However, date, no studies have performed examine the effect on epigenetic alterations, including CpG methylation. In this study, effects DNA methylation changes in breast cells were examined by treating cultured MCF-7 and MDA-MB-231 representing estrogen-positive estrogen-negative respectively, with plasma. A pyrosequencing analysis...
Abstract Cold atmospheric plasma (CAP) has been proposed as a useful cancer treatment option after showing higher induction of cell death in cells than normal cells. Although few studies have contributed to elucidating the molecular mechanism by which CAP differentially inhibits proliferation, no results are yet be reported related microRNA (miR). In this study, miR-19a-3p (miR-19a) was identified mediator proliferation-inhibitory effect MCF-7 breast cell. induced hypermethylation at...
Objective: Although the overall prognosis of CTD-related interstitial pneumonia is better than that idiopathic pneumonia, organizing (CTD-OP) was suggested to be worse cryptogenic (COP). The aim this study compare clinical features and outcome two conditions. Methods: A retrospective review 100 patients diagnosed by lung biopsy as having patterns (CTD, 24; COP, 76) at three tertiary referral centres. Results: Underlying CTDs were mostly RA, SS PM/DM. median follow-up period 43.6 months....
Abstract CD70 is expressed in normal activated immune cells as well several types of tumors. It has been established that anti-CD70 mAb induces complement-dependent death CD70+ tumor cells, but how affects the intrinsic signaling poorly defined. In this report, we show ligation on EBV-transformed B using induced production reactive oxygen species (ROS) and subsequent apoptosis. We observed an early expression endoplasmic reticulum (ER) stress response genes preceded release apoptotic...
Galectin-3 is involved in tumor cell proliferation, adhesion, angiogenesis and metastasis. promotes β-catenin/Wnt signaling, β-catenin-related oncogenesis has been frequently reported osteosarcoma. However, the correlation between galectin-3 β‑catenin signaling osteosarcoma poorly defined. We hypothesized that may control migration invasion of cancer cells silencing would therefore, suppress motility cells. In present study, we show cultured human had decreased capabilities; reduced...
Helicobacter pylori is associated with various diseases of the upper gastrointestinal tract, such as gastric inflammation and duodenal ulcers. The aim study was to assess anti-H. effects sesquiterpene lactone dehydrocostus (DCL) from Magnolia sieboldii leaves, compared commercial pure DCL, two previously known lactones (costunolide parthenolide), (–)-epigallocatechin gallate, four antibiotics. antibacterial activity natural DCL toward antibiotic-susceptible H. ATCC 700392 700824 strains...
Although Epstein-Barr virus (EBV)-associated keratitis is rare, it can cause acute corneal necrosis and neovascularization. We aimed to examine the signaling mechanism by which EBV causes epithelial-mesenchymal transition (EMT) in human epithelial cells (HCECs) vitro.The cellular response was assessed real-time PCR, Western blot, migration assay, invasion inhibitor ELISA assay.A model of EBV-induced EMT established HCECs. The induced morphologic changes cells; loss markers E-cadherin, ZO-1,...
Ginsenoside Rg3 is a key metabolite of ginseng and known to inhibit cancer cell growth. However, the epigenetics CpG methylation its regulatory mechanism have yet be determined. Genome-wide analysis MCF-7 breast cells treated with was performed identify epigenetically regulated genes pathways. The effect on apoptosis proliferation examined by colony formation assay dye-based assay. association between gene expression monitored RT-PCR Western blot analysis. identified “cell...
MiR-204 and miR-211 (miR-204/211) share the same seed site sequence, targeting many of genes. Their role in cancer development remains controversial, as both cell proliferative suppressive effects have been identified. This study aimed to address relationship between two structurally similar microRNAs (miRs) by examining their target genes depth well reveal contribution breast cells. Genome-wide pathway analysis with dysregulated after overexpression either miRs MCF-7 identified "Cancer"-...
Idiopathic nonspecific interstitial pneumonia (iNSIP) is recognized as a distinct entity among various types of idiopathic pneumonias. It identified histologically by the pattern. A diagnosis iNSIP feasible once secondary causes or underlying diseases are ruled out. Usually presenting with respiratory symptoms such shortness breath and cough, has subacute chronic course. predominantly affects females aged 50 to 60 years who non-smokers. Key imaging findings on chest high-resolution computed...