A5101994798- Anesthesia and Sedative Agents
- Ubiquitin and proteasome pathways
- Anesthesia and Neurotoxicity Research
- Cancer, Stress, Anesthesia, and Immune Response
- Remote Sensing and Land Use
- Respiratory Support and Mechanisms
- Advanced biosensing and bioanalysis techniques
- Plant Ecology and Soil Science
- RNA Research and Splicing
- Environmental Changes in China
- MicroRNA in disease regulation
- Intensive Care Unit Cognitive Disorders
- Advanced Nanomaterials in Catalysis
- Electrochemical sensors and biosensors
- Prostate Cancer Treatment and Research
- Anesthesia and Pain Management
- Pancreatic function and diabetes
- Medical Research and Treatments
- Ecology and Vegetation Dynamics Studies
- Water Resources and Sustainability
- Histone Deacetylase Inhibitors Research
- Environmental Quality and Pollution
- Plant and animal studies
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
Jiangsu University
2025
Liaocheng University
2024-2025
Weifang People's Hospital
2022-2025
East China Jiaotong University
2025
Chengdu Women's and Children's Central Hospital
2024
Chengdu Medical College
2024
FibroGen (United States)
2023-2024
Fourth Affiliated Hospital of China Medical University
2023-2024
China Medical University
2011-2024
Donghua University
2024
We report a facile approach to prepare an artificial enzyme system for tandem catalysis. NiPd hollow nanoparticles and glucose oxidase (GOx) were simultaneously immobilized on the zeolitic imidazolate framework 8 (ZIF-8) via co-precipitation method. The as-prepared GOx@ZIF-8(NiPd) nanoflower not only exhibited peroxidase-like activity of but also maintained enzymatic GOx. A colorimetric sensor rapid detection was realized through based multi-enzyme system. Moreover, modified electrode showed...
A novel one-pot strategy is proposed to fabricate 3D porous graphene (3D GN) decorated with Fe3O4 nanoparticles (Fe3O4 NPs) by using hemin as iron source. During the process, oxide was simultaneously reduced and self-assembled form hydrogel while NPs synthesized from distributed uniformly on GN. The preparation process simple, facile, economical, green. obtained freeze-dried product GH-5) exhibits outstanding peroxidase-like activity. Compared traditional 2D graphene-based nanocomposites,...
Current treatments for idiopathic pulmonary fibrosis slow the rate of lung function decline, but may be associated with adverse events that affect medication adherence. In phase 2 trials, pamrevlumab (a fully human monoclonal antibody binds to and inhibits connective tissue growth factor activity) attenuated progression without substantial events.
Modification by acetylation occurs at -amino lysine residues of histones and transcription factors.Unlike phosphorylation, a direct link between factor cellular growth or apoptosis has not been established.We show that the nuclear androgen receptor (AR), DNA-binding transcriptional regulator, is acetylated in vivo.The AR induced ligand dihydrotestosterone histone deacetylase (HDAC) inhibitors living cells.Direct augmented p300 binding vitro.Constructs mimicking neutral polar substitution (AR...
The cyclin D1 gene encodes the labile serum-inducible regulatory subunit of a holoenzyme that phosphorylates and inactivates retinoblastoma protein. Overexpression promotes cellular proliferation normal physiological levels function to inhibit adipocyte differentiation in vivo. We have previously shown inhibits peroxisome proliferator-activated receptor (PPAR)gamma-dependent activity through cyclin-dependent kinase- protein-binding-independent mechanism. In this study, we determined...
The NAD-dependent histone deacetylase Sir2 plays a key role in connecting cellular metabolism with gene silencing and aging. androgen receptor (AR) is ligand-regulated modular nuclear governing prostate cancer proliferation, differentiation, apoptosis response to androgens, including dihydrotestosterone (DHT). Here, SIRT1 antagonists induce endogenous AR expression enhance DHT-mediated expression. binds deacetylates the at conserved lysine motif. Human (hSIRT1) repression of DHT-induced...
Cyclin D1 is overexpressed in human tumors, correlating with cellular metastasis, and induced by activating Rho GTPases. Herein, cyclin D1-deficient mouse embryo fibroblasts (MEFs) exhibited increased adhesion decreased motility compared wild-type MEFs. Retroviral transduction of reversed these phenotypes. Mutational analysis demonstrated that its effects on migration were independent the pRb p160 coactivator binding domains. Genomewide expression arrays identified a subset genes regulated...
The cyclin D1 gene encodes a regulatory subunit of the holoenzyme that phosphorylates and inactivates pRb tumor suppressor to promote nuclear DNA synthesis.cyclin is overexpressed in human breast cancers sufficient for development murine mammary tumors.Herein, shown perform novel function, inhibiting mitochondrial function size.Mitochondrial activity was enhanced by genetic deletion or antisense small interfering RNA D1.Global expression profiling functional analysis epithelial cell-targeted...
The bridge-type mechanism is highly valued as a displacement amplifier in precision engineering due to its compact and symmetrical design. Nonetheless, it suffers from drawback of limited magnification, which hampers broader application. To overcome this limitation, paper proposes compliant amplification that integrates two mechanisms with lever-type mechanism. This novel design not only retains structure but also achieves large ratio high natural frequency, surpassing traditional designs....
Abstract We report a facile approach to prepare an artificial enzyme system for tandem catalysis. NiPd hollow nanoparticles and glucose oxidase (GOx) were simultaneously immobilized on the zeolitic imidazolate framework 8 (ZIF‐8) via co‐precipitation method. The as‐prepared GOx@ZIF‐8(NiPd) nanoflower not only exhibited peroxidase‐like activity of but also maintained enzymatic GOx. A colorimetric sensor rapid detection was realized through based multi‐enzyme system. Moreover, modified...
This study aimed to evaluate the effect of low molecular weight Acanthopanax polysaccharides on simulated digestion, probiotics, and intestinal flora broilers in vitro. The experiments were carried out by H2O2-Vc degradation polysaccharides, vitro digestion digestive performance with different weights, probiotic evaluation lactobacilli bifidobacteria, anaerobic fermentation high-throughput sequencing 16S rRNA genes impact broilers, short-chain fatty acids intestines determined GC-MS method....
The aim of this experiment was to investigate the modulation effect Acanthopanax senticosus polysaccharide (ASPS-PD) extracted with deep eutectic solvent on cyclophosphamide-induced immunosuppression in broilers and its gut microbiota broilers. 108 one-day-old were divided into six groups, including control group, Cyclophosphamide (CY) model ASPS-PD ASPA-PD high low dose groups Astragalus group. Body weight, feed intake, conversion ratio, immune organ index at 7, 14, 21 days determined;...
Cyclin D1 encodes a regulatory subunit, which with its cyclin-dependent kinase (Cdk)-binding partner forms holoenzyme that phosphorylates and inactivates the retinoblastoma protein. In addition to Cdk binding-dependent functions, cyclin regulates cellular differentiation in part by modifying several transcription factors nuclear receptors. The molecular mechanism through function of involved remains be clarified. histone acetyltransferase protein p300 is co-integrator required for regulation...
Abstract Prostate epithelial cells grown embedded in laminin-rich extracellular matrix (lrECM) undergo morphologic changes that closely resemble their architecture vivo. In this study, growth characteristics of three human prostate sublines derived from the same cellular lineage, but displaying different tumorigenic and metastatic properties vivo, were assessed three-dimensional lrECM gels. M12, a highly subline, was immortalized, P69 cell line by selection athymic, nude mice found to...