A5010701166- Chronic Obstructive Pulmonary Disease (COPD) Research
- Air Quality and Health Impacts
- Pneumonia and Respiratory Infections
- Heavy Metal Exposure and Toxicity
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Noise Effects and Management
- Asthma and respiratory diseases
- Respiratory viral infections research
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Pneumocystis jirovecii pneumonia detection and treatment
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Respiratory Support and Mechanisms
- Vitamin D Research Studies
- Sepsis Diagnosis and Treatment
- Occupational and environmental lung diseases
- Advanced biosensing and bioanalysis techniques
- S100 Proteins and Annexins
- Influenza Virus Research Studies
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Pregnancy and preeclampsia studies
Peking University People's Hospital
2025
Peking University
2025
Anhui Medical University
2014-2024
Second Hospital of Anhui Medical University
2014-2024
Yueqing People's Hospital
2024
Nantong University
2024
Affiliated Hospital of Nantong University
2024
Northwest University
2023
Fudan University
2023
Wenzhou Medical University
2023
We noted an unexpected inheritance pattern of lesions in several strains gene-manipulated mice with ocular phenotypes. The lesions, which appeared at various stages backcross to C57BL/6, bore resemblance the rd8 retinal degeneration phenotype. set out examine prevalence this mutation induced mutant mouse lines, vendor C57BL/6 and widely used embryonic stem cells.Ocular were evaluated by fundus examination histopathology. Detection genetic level was performed PCR appropriate primers. Data...
A novel coronavirus (COVID-19) has raised world concern since it emerged in Wuhan, China December 2019. The infection may result severe pneumonia with clusters of illness onsets. Its impacts on public health make paramount to clarify the clinical features other pneumonias.Nineteen COVID-19 and 15 patients (non-COVID-19) areas outside Hubei were involved this study. Both non-COVID-19 confirmed be infected using throat swabs and/or sputa with/without COVID-2019 by real-time RT-PCR. We analyzed...
Importance For patients with non–small cell lung cancer whose disease progressed while receiving EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy, particularly third-generation TKIs, optimal treatment options remain limited. Objective To compare the efficacy of ivonescimab plus chemotherapy alone for relapsed advanced or metastatic epidermal growth factor receptor ( ) variant. Design, Setting, and Participants Double-blind, placebo-controlled, randomized, phase 3 trial at 55 sites in China...
Current treatments for idiopathic pulmonary fibrosis slow the rate of lung function decline, but may be associated with adverse events that affect medication adherence. In phase 2 trials, pamrevlumab (a fully human monoclonal antibody binds to and inhibits connective tissue growth factor activity) attenuated progression without substantial events.
The goal of this study was to analyze whether mitochondria-associated endoplasmic reticulum membrane (MAMs) dysfunction mediated arsenic (As)-evoked pulmonary ferroptosis and acute lung injury (ALI). As exposure led alveolar structure damage, inflammatory cell infiltration function decline in mice. Ferritin, the marker iron overload, increased, GPX4, index lipid peroxidation, decreased As-exposed lungs epithelial cells (MLE-12). Pretreatment with ferrostatin-1 (Fer-1), inhibitor ferroptosis,...
Data are limited on the impact of neuraminidase inhibitor (NAI) treatment avian influenza A(H7N9) virus RNA shedding.In this multicenter, retrospective study, data were collected from adults hospitalized with infection during 2013-2017 in China. We compared clinical features and shedding among patients different NAI doses combination therapies evaluated factors associated shedding, using Cox proportional hazards regression.Among 478 patients, median age was 56 years, 71% male, 37% died. The...
Several reports indicate that melatonin alleviates bleomycin (BLM)-induced pulmonary fibrosis in rodent animals. Nevertheless, the exact mechanism remains obscure. The present study investigated effects of on endoplasmic reticulum (ER) stress and epithelial-mesenchymal transition (EMT) during BLM-induced lung fibrosis. For induction fibrosis, mice were intratracheally injected with a single dose BLM (5.0 mg/kg). Some intraperitoneally (5 mg/kg) daily for period 3 wk. Twenty-one days after...
Abstract Obesity is a major contributor to the development of steatohepatitis and fibrosis from nonalcoholic fatty liver disease (NAFLD). Hypoxia aggravates progression NAFLD. In mice on high‐fat diet (HFD), hepatic steatosis leads tissue hypoxia, evidenced by accumulation hypoxia inducible factor‐1‐alpha (HIF‐1α), which central regulator global response hypoxia. Hepatocyte cell signaling an important factor in fibrogenesis. We here hypothesize that HIF‐1α knockout hepatocyte may protect...
Abstract Vitamin D receptor (VDR) is highly expressed in human and mouse kidneys. Nevertheless, its functions remain obscure. This study investigated the effects of vitamin D3 (VitD3) pretreatment on renal inflammation during lipopolysaccharide (LPS)-induced acute kidney injury. Mice were intraperitoneally injected with LPS. In VitD3 + LPS group, mice pretreated (25 μg/kg) at 48, 24 1 h before injection. As expected, an obvious reduction function pathological damage was observed LPS-treated...
Abstract Background Coronavirus disease 2019 (COVID-19) triggered by infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been widely pandemic all over the world. The aim of this study was to analyze influence factors death risk among 200 COVID-19 patients. Methods Two hundred patients confirmed SARS-CoV-2 were recruited. Demographic data and clinical characteristics collected from electronic medical records. Biochemical indexes on admission measured patient’s...
Vitamin D deficiency is associated with increased risks of chronic obstructive pulmonary disease (COPD). Nevertheless, the mechanisms remain unknown. This study analyzed correlations between vitamin levels and inflammation in COPD patients. One hundred one patients 202 control subjects were enrolled. Serum 25(OH)D level inflammatory cytokines detected. was decreased According to forced expiratory volume 1 s, divided into three grades. Furthermore, serum gradually ranging from grade 1-2 4....
Abstract Coronavirus disease 2019 (COVID-19) is a newly emerged infection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has been pandemic all over the world. This study described kidney injury (AKI) at early stage COVID-19 its clinical significance. Three-hundred fifty-five patients with were recruited data collected from electronic medical records. Patient’s prognosis was tracked risk factors AKI analyzed. Of 355 patients, common, critical ill cases accounted for...
Vitamin D deficiency is correlated with the increased morbidity of chronic obstructive pulmonary disease (COPD). However, mechanisms underlying these effects have largely remained elusive. This study analyzed correlations among COPD, vitamin concentration, and epithelial-mesenchymal transition (EMT). Ninety-five patients newly diagnosed COPD 190 age- sex-matched healthy subjects were recruited for this research. Serum 25(OH)D levels detected, EMT biomarkers TGF-β/Smad signaling evaluated....
Abstract Introduction Increasing evidence indicate that coronavirus disease 2019 (COVID-19) is companied by renal dysfunction. However, the association of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)-induced dysfunction with prognosis remains obscure. Materials and methods All 154 patients COVID-19 were recruited from Second People’s Hospital Fuyang City in Anhui, China. Demographic characteristics laboratory data extracted. Renal was evaluated its followed up based on a...