A5101967647- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- CAR-T cell therapy research
- Colorectal Cancer Treatments and Studies
- Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Traditional Chinese Medicine Studies
- Anesthesia and Pain Management
- Cutaneous Melanoma Detection and Management
- Bladder and Urothelial Cancer Treatments
- Nausea and vomiting management
- Ferroptosis and cancer prognosis
- Melanoma and MAPK Pathways
- Lung Cancer Treatments and Mutations
- Migraine and Headache Studies
- Immunotherapy and Immune Responses
- Genetics and Neurodevelopmental Disorders
- Liver Disease Diagnosis and Treatment
- Syphilis Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Cancer Treatment and Pharmacology
Xingtai People's Hospital
2018-2025
Hebei Medical University
2018-2025
Peking University
2014-2023
Peking University Cancer Hospital
2014-2023
Chengdu University of Traditional Chinese Medicine
2021-2022
University of Cincinnati
2019
Tianjin University
2018
Hubei University of Medicine
2017
Shuguang Hospital
2014
Shanghai University of Traditional Chinese Medicine
2014
Importance For patients with non–small cell lung cancer whose disease progressed while receiving EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy, particularly third-generation TKIs, optimal treatment options remain limited. Objective To compare the efficacy of ivonescimab plus chemotherapy alone for relapsed advanced or metastatic epidermal growth factor receptor ( ) variant. Design, Setting, and Participants Double-blind, placebo-controlled, randomized, phase 3 trial at 55 sites in China...
Introduction Autism spectrum disorder (ASD) encompasses a diverse range of neurodevelopmental disorders with complex etiologies, including genetic, environmental, and neuroanatomical factors. While the exact mechanisms underlying ASD remain unclear, structural abnormalities in brain offer valuable insights into its pathophysiology. The corpus callosum, largest white matter tract brain, plays crucial role interhemispheric communication, may contribute to ASD-related phenotypes. Methods To...
Background Currently, studies have shown that anti-CGRP monoclonal antibodies are effective drugs for the prophylaxis and treatment of episodic migraine. Therefore, first time, we classified concluded 10 regimens according to different doses, drugs, routes administration, courses treatment, so as provide a reference further clinical studies.Methods We studied relevant randomized controlled trials (RCTs) published before August 2020 on PubMed, Embase, Ovid MEDLINE, Web Science, Cochrane...
Abstract Background Anti-programmed cell death receptor-1 (PD-1) monotherapy is the standard treatment for metastatic melanoma in current. Camrelizumab a humanized IgG4 anti-PD-1 monoclonal antibody whose safety and efficacy have not been reported advanced Asian patients. Methods This phase I study investigated safety, activity, pharmacokinetics of camrelizumab Chinese patients with melanoma. The included two phases, dose-escalation (“3 + 3” design at 60 mg, 200 400 mg) dose-expansion phase....
To investigate the effect of apatinib when treating advanced gastric cancer (GC) as well mechanism preventing infection.From January 2017 to December 2018, 100 GC patients had failed receive second-line or above treatment in XX Hospital were divided into two groups according experimental requirements: group and blank group. The was treated with small molecule targeted drug apatinib, while only ordinary drugs. After 4 weeks treatment, diagnosis evaluation carried out every eight weeks. In...
The combination of programmed death 1 (PD-1) inhibitors and cytotoxic T lymphocyte-associated antigen-(CTLA-4) have markedly improved the survival melanoma patients. We report case a patient with advanced who developed asthma during anti-PD-1 anti-CTLA-4 therapy. was 57-year-old woman enrolled in clinical trial regarding novel CTLA-4 antibody sintilimab treatment. diagnosed after three cycles Subsequently, she treated corticosteroids, shortcostero β2 agonists, antihistamines. symptoms were...
The pathogenic mechanisms underlying the autonomic nervous system (ANS) dysfunction in patients with chronic migraine (CM) remain unclear. This study investigated pathogenesis of ANS this population.A total 60 diagnosed CM and healthy subjects were recruited to participate study. pupil diameter, contraction velocity, latency, amplitude, maximum gradient recovery time examined before, at 2 min 5 after cold pressor test, which was combined pupillary light reflex method. A brain 3D T1-weighted...
// Bao-Xia Fang 1, * , Fu-Chao Chen Dan Zhu 2 Jun Guo 3 and Lin-Hai Wang 1 Department of Pharmacy, Dongfeng Hospital, Hubei University Medicine, Shiyan, 442008, P.R. China Renmin 442000, Oncology, These authors contributed equally to this work Correspondence to: Wang, email: wanglhpharmacy@sina.com Keywords: chemotherapy-induced nausea vomiting; antiemetic; dexamethasone; azasetron; drug stability Received: May 30, 2017 Accepted: October 13, Published: 31, 2017...
9573 Background: Immunotherapies including anti PD-1 ab and high-dose IFN-a2b (HDI) have been approved for adjuvant therapies in resected cutaneous melanoma, but their roles mucosal melanoma are still unknown. To determine the efficacies of toripalimab versus HDI as therapy patients (pts) with this open-label, phase randomized trial was conducted. Methods: Mucosal pts who undergone complete resections localized or without regional lymphatic disease were randomly (1:1) assigned to receive...
137 Background: The aim of this study was to observe the safety apatinib in real world with wider inclusion criteria. efficacy evaluated including overall survival (OS), progression-free (PFS), objective response rate (ORR) and disease control (DCR). Methods: This trial enrolled patients from 32 centers china advanced gastric adenocarcinoma who had progressed after undergoing at least two lines systemic chemotherapy, or were considered benefit treatment. We recommended starting oral...
e15042 Background: To investigate the efficacy in terms of overall response rate and progression-free survival (PFS) time combination gemcitabine, fluorouracil, sorafenib for metastatic renal cell carcinoma (RCC) a multicenter phase II clinical trial. Methods: Patients were enrolled at seven centers across China between November 2008 April 2010. aged 18 years or older, had confirmed RCC with clear-cell histology, an Eastern Cooperative Oncology Group performance status 0 1, not undergone...
9539 Background: Patients(pts) with metastatic acral melanoma respond poorly to anti–PD-1 monotherapy. Apatinib, a vascular endothelial growth factor (VEGF) inhibitor, is kind of anti-angiogenic drugs which have shown synergistic therapeutic effects in combination PD-1 blockade. We conducted this single-center, open label phase trial evaluate the safety and efficacy camrelizumab apatinib advanced treatment-naïve pts. Methods: Eligible participants were adult pts (aged 18 75) histologically...
e16047 Background: This study observed the efficacy and safety of apatinib in patients with advanced gastric adenocarcinoma, helping elucidate optimal initial dose real world wider inclusion criteria. Methods: trial enrolled patients(pts) from 32 centers China who had disease progression after at least two lines systemic chemotherapy, or pts were considered to be benefit treatment. Pts received oral 500 mg once daily, could adjusted according pts’ physical condition doctors’ experience. The...