A5077589099- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Respiratory Support and Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Research Studies
- Mycobacterium research and diagnosis
- Sepsis Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Cancer Genomics and Diagnostics
- Airway Management and Intubation Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Lymphatic Disorders and Treatments
- Medical Imaging Techniques and Applications
- Cancer-related molecular mechanisms research
- Congenital Diaphragmatic Hernia Studies
- Pneumonia and Respiratory Infections
- Ultrasound in Clinical Applications
- Extracellular vesicles in disease
- Gastric Cancer Management and Outcomes
Pusan National University
2016-2025
Pusan National University Hospital
2016-2025
University of Cincinnati Medical Center
2024
Cincinnati Children's Hospital Medical Center
2024
Biomedical Research Institute
2021-2024
University of Auckland
2024
Busan National University of Education
2019-2023
Asan Medical Center
2010-2019
Pulmonary and Allergy Associates
2019
University of Ulsan
2019
To evaluate the efficacy of combined vitamin C, hydrocortisone, and thiamine in patients with severe pneumonia.All consecutive pneumonia who were treated C protocol (6 g per day) June 2017-January 2018 (n = 53) compared to all 2016-January 2017 46). Propensity score analysis was used adjust for potential baseline differences between groups.In propensity-matched cohort 36/group), had significantly less hospital mortality than control group (17% vs. 39%; P 0.04). The associated independently...
Chronic pulmonary aspergillosis (CPA) is a relatively uncommon disease that has been poorly characterized. This study investigated the clinical features and treatment outcomes of CPA through retrospective review records patients with newly diagnosed between January 2008 2012. A total 70 patients, which included 51 (73%) males, had median age 55 years. Fifty-seven (81%) history tuberculosis caused by nontuberculous mycobacteria (NTM) was primary underlying condition in 32 (46%). Most (n = 66;...
Background Low‐dose computed tomography can identify smaller nodules more often than chest radiography in lung screening. However, complications from invasive diagnostic procedures performed to detect are common. Exosomes contain a diverse array of biomolecules that reflect the biological state cell which they released. The aim this study was investigate value bronchoalveolar lavage (BAL) fluid exosomal microRNAs (miRNAs) for early‐stage adenocarcinoma. Methods We evaluated miRNAs (miR‐7,...
Patient- and procedure-related factors associated with postoperative pulmonary complications (PPCs) have changed over the last decade. Therefore, we sought to identify independent risk of PPCs develop a clinically applicable scoring system. We retrospectively analyzed clinical data from 2,059 patients who received preoperative evaluations respiratory physicians between June 2011 October 2012. A new system for estimating was developed using beta coefficients final multiple regression models....
Despite the obvious benefits of adding immune checkpoint inhibitors to platinum-etoposide chemotherapy in patients with extensive-stage small-cell lung cancer (ES-SCLC), real-world data remain scarce.This retrospective study included 89 ES-SCLC treated alone (chemo-only group; n = 48) or combination atezolizumab (atezolizumab 41) and compared survival outcomes between these two groups.Overall (OS) was significantly longer group than chemo-only (15.2 months vs. 8.5 months; p 0.047), whereas...
The diagnostic yield of transbronchial biopsy (TBB) using radial probe endobronchial ultrasound (RP-EBUS) is 71%, which lower than that transthoracic needle biopsy. We investigated the performance and safety sequential cryobiopsy (TBC) a novel 1.1-mm diameter cryoprobe, after conventional TBB RP-EBUS for diagnosis peripheral lung lesions (PLLs).From April 2021 to November 2021, 110 patients who underwent bronchoscopy PLL ≤ 30 mm were retrospectively included in our study. All records...
Purpose There have been efforts to find alternative samples other than standard of tissue or plasma for mutational analyses lung cancer patients. However, no sample technique has replaced the using samples. In this prospective study, we assessed a novel bronchoscopy method, named as targeted washing technique, detecting EGFR mutation. Materials and Methods A 3.0-mm ultrathin bronchoscope was precisely navigated target lesion with assistance virtual bronchoscopic navigation fluoroscopy. Once...
Abstract Background and Objective Next‐generation sequencing (NGS) analysis is considered standard for lung cancer diagnosis in clinical practice. Little known about the feasibility of NGS using tumour tissue sampled with a 1.1 mm‐diameter cryoprobe. We aimed to investigate suitability specimens obtained by transbronchial cryobiopsy (TBC) cryoprobe analysis. Methods Patients who underwent TBC testing between October 2020 April 2023 were enrolled. A 4.0‐ or 3.0 bronchoscope radial probe...
The detection of epidermal growth factor receptor (EGFR) mutation, based on tissue biopsy samples, provides a valuable guideline for the prognosis and precision medicine in patients with lung cancer. In this study, we aimed to examine minimally invasive bronchial washing (BW)-derived extracellular vesicles (EVs) EGFR mutation analysis A lab-on-a-disc equipped filter 20-nm pore diameter, Exo-Disc, was used enrich EVs BW samples. overall sensitivity mutations 55 BW-derived samples 89.7% 31.0%...
Generally, structural destruction of lung parenchyma, such as pulmonary emphysema, is considered to be related the low diagnostic yields and high complication rates biopsies peripheral lesions. Currently, little known about clinical outcomes using endobronchial ultrasound with a guide sheath (EBUS-GS) diagnose lesions in patients emphysema. This retrospective study was performed identify EBUS-GS included 393 consecutive who received between February 2017 April 2018. The were classified...
ABSTRACT Background and objective Post‐intubation tracheal stenosis ( PITS ) post‐tracheostomy PTTS are serious complications in mechanically ventilated patients. Although the aetiologies mechanisms of quite different, little is known about clinical impact differentiating one from other. Methods We retrospectively conducted a chart review 117 patients with 88 who were treated interventional bronchoscopy at Samsung Medical Center between January 2004 December 2013. Results Compared to , had...
The high background rates of positive results on the tuberculin skin test (TST) and interferon-gamma release assay (IGRA) sometimes confuse investigation tuberculosis (TB) contact in TB-prevalent countries, particularly elderly contacts. aim was to investigate predictive value TST IGRA for diagnosing latent TB infection (LTBI) household contacts South Korea. In this retrospective study, suspected pulmonary patients were reviewed according index patient's final diagnosis (TB group:...
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is widely used to perform mediastinal lymph node sampling. However, little information available on polymerase chain reaction for Mycobacterium tuberculosis (TB-PCR) using EBUS-TBNA samples in patients with intrathoracic granulomatous lymphadenopathy (IGL).A retrospective study a prospectively collected database was performed from January 2010 December 2014 evaluate the efficacy of TB-PCR test IGL. During period, 87...
We evaluated the clinical utility of rapid identification microorganisms in bronchoalveolar lavage (BAL) fluid using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) terms outcomes ventilated patients with pneumonia.Patients for whom were identified via MALDI-TOF MS (from March 2013 to February 2014; post-intervention group) compared conventional methods 2012 2013; pre-intervention group). All pneumonia types (community-acquired, hospital-acquired,...
We aimed to develop a decision tree model improve diagnostic performance of positron emission tomography/computed tomography (PET/CT) detect metastatic lymph nodes (LN) in non-small cell lung cancer (NSCLC). 115 patients with NSCLC were included this study. The training dataset 66 patients. A was developed 9 variables, and validated 49 patients: short long diameters LNs, ratio diameters, maximum standardized uptake value (SUVmax) LN, mean hounsfield unit, LN SUVmax ascending aorta (LN/AA),...
Background The aim of our study was to evaluate the prognostic value Charlson's weighted index comorbidities (WIC) in patients with prolonged acute mechanical ventilation (PAMV, ventilator care ≥96 hours). Methods We retrospectively enrolled 299 Korean PAMV who were admitted a medical intensive unit (ICU) university-affiliated tertiary hospital between 2008 and 2013. Survivors defined as survived for 60 days after ICU admission. Results patients' mean age 65.1±14.1 years 70.6% male. length...
Background This study compared the treatment outcomes of patients with multidrug-resistant tuberculosis (MDR-TB) before and after implementation public-private mix (PPM). Factors affecting success were also investigated. Methods Data from culture-confirmed pulmonary MDR-TB who commenced at Pusan National University Hospital between January 2003 December 2017 retrospectively reviewed. Patients divided into two groups in terms PPM status: pre-PPM period, 2010; post-PPM treated 2011 2017....