Despite the obvious benefits of adding immune checkpoint inhibitors to platinum-etoposide chemotherapy in patients with extensive-stage small-cell lung cancer (ES-SCLC), real-world data remain scarce.This retrospective study included 89 ES-SCLC treated alone (chemo-only group; n = 48) or combination atezolizumab (atezolizumab 41) and compared survival outcomes between these two groups.Overall (OS) was significantly longer group than chemo-only (15.2 months vs. 8.5 months; p 0.047), whereas...

Objectives The effect of air pollution on the prognosis rheumatoid arthritis-associated interstitial lung disease (RA-ILD) remains poorly understood. We aimed to evaluate long-term exposure particulate matter with an aerodynamic diameter ≤10 µm (PM 10 ) and nitrogen dioxide (NO 2 mortality in patients RA-ILD. Methods included 309 (mean age, 61.7 years; male, 44.3%) Individual-level exposures PM NO at their residential addresses were estimated using a national-scale prediction model. two...

Purpose There have been efforts to find alternative samples other than standard of tissue or plasma for mutational analyses lung cancer patients. However, no sample technique has replaced the using samples. In this prospective study, we assessed a novel bronchoscopy method, named as targeted washing technique, detecting EGFR mutation. Materials and Methods A 3.0-mm ultrathin bronchoscope was precisely navigated target lesion with assistance virtual bronchoscopic navigation fluoroscopy. Once...

Background/Aims: Tracheostomy is a crucial intervention for severe pneumonia patients requiring prolonged mechanical ventilation (MV). However, debate persists regarding the influence of tracheostomy timing and performance on long-term survival outcomes. This study utilized propensity score matching to assess impact patient outcomes.Methods: A retrospective observational employing was conducted respiratory intensive care unit (ICU) who underwent acute MV due from 2008 2023. The primary...

The diagnostic yield of transbronchial biopsy (TBB) using radial probe endobronchial ultrasound (RP-EBUS) is 71%, which lower than that transthoracic needle biopsy. We investigated the performance and safety sequential cryobiopsy (TBC) a novel 1.1-mm diameter cryoprobe, after conventional TBB RP-EBUS for diagnosis peripheral lung lesions (PLLs).From April 2021 to November 2021, 110 patients who underwent bronchoscopy PLL ≤ 30 mm were retrospectively included in our study. All records...

Abstract Background and Objective Next‐generation sequencing (NGS) analysis is considered standard for lung cancer diagnosis in clinical practice. Little known about the feasibility of NGS using tumour tissue sampled with a 1.1 mm‐diameter cryoprobe. We aimed to investigate suitability specimens obtained by transbronchial cryobiopsy (TBC) cryoprobe analysis. Methods Patients who underwent TBC testing between October 2020 April 2023 were enrolled. A 4.0‐ or 3.0 bronchoscope radial probe...

Background: The modified NUTRIC (nutritional risk in the critically ill) score has been reported to predict clinical outcomes ill patients. However, applicability of this may differ between patients undergoing short-term mechanical ventilation (STMV, < 96 h) and those prolonged acute (PAMV, ⩾96 h), as PAMV typically experience significantly higher morbidity mortality. Objective: This study aimed investigate predictive ability for predicting 28-day mortality receiving STMV PAMV. Design:...

Detection of the epidermal growth factor receptor (EGFR) T790M mutation using plasma samples has been considered simple and non-invasive, but relatively high false negative results lead to additional tissue sampling in some patients. Until now, characteristics patients who prefer liquid biopsy have not yet established.To evaluate favorable conditions for detection mutations samples, a multicenter retrospective study was performed between May 2018 December 2021. Patients whose detected sample...

The identification of blood biomarkers to diagnose acute exacerbation chronic obstructive pulmonary disease (AECOPD) will have clinical utility. Here, we used a proteomics-based approach identify capable identifying AECOPD.This prospective, single-center pilot study enrolled 12 patients who came Asan Medical Center (South Korea) via the outpatient clinic or emergency department with symptoms AECOPD and were follow-up in during convalescence between 2015 2017. Paired samples collected from...

Background and Objectives: This study aimed to assess the value of a novel prognostic model, based on clinical variables, comorbidities, demographic characteristics, predict long-term prognosis in patients who received mechanical ventilation (MV) for over 14 days underwent tracheostomy during first MV. Materials Methods: Data were obtained from 278 (66.2% male; median age: 71 years) within MV February 2011 2021. Factors predicting 1-year mortality after initiation identified by binary...

After the successful development of targeted therapy and immunotherapy for treatment advanced-stage non-small cell lung cancer (NSCLC), these innovative options are rapidly being applied in adjuvant setting early-stage NSCLC. Some adjuvants that have recently been approved include osimertinib epidermal growth factor receptor-mutated tumors atezolizumab pembrolizumab selected patients with resectable Numerous studies on various therapies or without chemotherapy currently ongoing setting....

Background The utility of computed tomography (CT) in the differential diagnosis patients with chronic obstructive pulmonary disease (COPD) exacerbation remains uncertain. However, due to low cost associated CT scan along impact Koreas' health insurance system, there has been a rise number scans initial COPD exacerbations. Therefore, was investigated determine whether performing affect clinical outcomes an exacerbation. Methods This study involved 202 hospitalized We evaluated change or...

Pulmonary endarterectomy (PEA) is the gold standard for treating chronic thromboembolic pulmonary hypertension (CTEPH) in Western countries. The aim of this study was to investigate long-term outcomes performing PEA on CTEPH patients comparison with medical therapy at a single Korean center.

Abstract Objective For thoracoscopy, the usefulness of a dye mixture indigo carmine and Lipiodol for localizing lung lesions has been reported. However, little is known about stability safety this injected on visceral pleura through bronchoscope. Methods Porcine models were divided into three groups according to detection time mixture: group A with 4 h; B, 8 C, 24 h. (0.5 mL each) was sprayed onto both in ventral dorsal regions via spray catheter. Results Twelve markings created porcine (six...

Despite the burden of bronchiectasis, there is little data from South Korea regarding asymptomatic bronchiectasis. We aimed to investigate prevalence bronchiectasis based on computed tomography (CT) findings, with emphasis (CT-proven) and its related factors. analysed individuals who underwent chest CT at a Korean health screening centre 2016 2017. The was evaluated adjusted by sex, age, corresponding year for general population. Logistic regression analysis performed identify factors...

The present study evaluated the association between participation in a rehabilitation program during hospital stay and 1-year survival of patients requiring at least 21 days mechanical ventilation (prolonged [PMV]) with various respiratory diseases as their main diagnoses that led to ventilation. Retrospective data 105 (71.4% male, mean age 70.1±11.3 years) who received PMV past 5 years were analyzed. Rehabilitation included physiotherapy, physical rehabilitation, dysphagia treatment was...

Since the introduction of low-dose computed tomography (CT) screening for patients at high risk lung cancer, detection rate suspicious cancer has increased. In addition, there have been many advances in therapeutics targeting oncogenic drivers non-small cell cancer. Therefore, accurate pathological diagnosis including molecular diagnosis, is increasingly important. This review examines problems suspected For successful clinicians should determine appropriate modality diagnostic procedure,...

The main purpose of this study was to develop a model predictive dysphagia in hospital survivors with severe pneumonia who underwent tracheostomy during their stay. present included 175 patients (72% male; mean age, 71.3 years) over 5 years. None these had history deglutition disorder before admission. Binary logistic regression analysis performed identify factors predicting at discharge. Dysphagia scores were calculated from β-coefficients and by assigning points variables. Of the enrolled...