Abstract Background The tumor-associated calcium signal transducer ( TACSTD ) genes, originally designated epithelial cell adhesion molecule (EpCAM) and TROP2, represent true oncogenes. Little is known about EpCAM TROP2 gene expression in non-small lung carcinoma (NSCLC). This study evaluated protein clinicopathologic significance cases of NSCLC. Methods Tissue microarray blocks acquired from 164 NSCLC, including 100 adenocarcinoma (AdC) 64 squamous (SCC), were examined by...

The effect of monoclonal antibody (mAb) affinity on the detection limit enzyme-linked immunosorbent assay (ELISA), surface plasmon resonance (SPR), and electrochemiluminescence (ECL) methods was evaluated using a panel murine mAbs with affinities ranging from 0.057 to 340 nM. M1 M7 are anti-idiotypic against human mAb, ABX10, dissociation equilibrium constant (KD) values 7.2 nM, respectively. HP6030 HP6002 antihuman IgG KD 30 (LOD) for these determined ELISA, SPR, ECL technologies generally...

Gastric cancer (GC) is a pressing global health concern, with prognosis intricately linked to the tumour stage and microenvironment, especially, presence of immune cells. Notably, CD8 + T cells play pivotal role in anti-tumour response, prompting investigations into their correlation GC survival. This study aimed investigate intricate interplay between cells, particularly within context CXCR6, survival outcomes patients GC. Utilising datasets from The Cancer Genome Atlas, Gene Expression...

Colorectal cancer is the major cause of mortality, despite development therapeutic strategies. The novel marker tumor necrosis factor receptor-associated protein 1 (TRAP1) a mitochondrial heat shock that has been related to drug resistance and protection from apoptosis in colorectal cancer. This study aims delineate clinicopathologic significance TRAP1 expression Seven-hundred fourteen FFPE tissues were collected patients who underwent surgery February 2002 July 2011 at Dong-A University...

Lung cancer is the leading cause of mortality, despite development therapeutic strategies. Altered expression microRNAs(miRNAs) in human malignancies have been well recognized as diagnostic and prognostic indicators, including lung cancer. This study aims to delineate clinicopathologic significance three unique miRNAs adenocarcinoma according major sensitive EGFR mutation status. One-hundred formalin-fixed paraffin-embedded (FFPE) tissues were collected from patients who underwent surgery...

2602 Background: MEDI4736 is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody directed against programmed death ligand 1 (PD-L1). blocks inhibitory interaction of PD-L1 with the PD-1 (CD279) and B7-1 (CD80) molecules, enhances T-cell activation. The primary objectives this analysis were to assess pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity in patients advanced solid tumors. Methods: Data collected from Phase study (NCT01693562) designed evaluate safety,...

The sequential reactive changes in Schwann cell phenotypes transected peripheral nerves, including dedifferentiation, proliferation and migration, are essential for nerve repair. Even though the injury-induced migratory proliferative behaviors of cells resemble epithelial mesenchymal transition (EMT) tumors, molecular mechanisms underlying this phenotypic change still unclear. Here we show that exhibit features dependent on expression a scaffolding oncoprotein Grb2-associated binder-2...

Abstract Objective Programmed cell death ligand‐1 ( PD ‐L1) has emerged as a predictive biomarker in lung cancer. ‐L1 immunohistochemistry IHC ) assay predicts the response to immunotherapy, but cytology specimens are often only samples available considerable proportion of advanced cancer patients. We delineate practical feasibility and efficacy cell‐block CB for expression concordance between s surgical resection specimens. Methods In total, 58 eligible patients with primary who received...

An aneurysmal bone cyst (ABC) is believed to be attributable intraosseous circulatory disturbance. ABC a vascular tumor of the caused by bony expansion after partial occlusion and congestion. Most ABCs are found in adolescents (approximately 75% observed patients under 20 years age). The most common sites long bones limbs, vertebrae, cranial bone. Aneurysmal cysts skull base or ethmoid sinus have been but rarely reported worldwide. authors report on patient with very large sinus; this was...

Protein arginine methyltransferase-5 (PRMT5), a major type II methyltransferase, is an important epigenetic modifier with oncogene-like properties because of its ability to repress the expression tumor suppressor genes. We determined correlations between PRMT5 or cellular localization and malignant progression, special reference invasiveness, in colorectal adenomas early carcinomas (CRCs). performed immunohistochemical detection 108 endoscopically resected tissue samples (6 low-grade...

e14009 Background: MEDI4736 is a human IgG1 mAb that blocks PD-L1 binding to PD-1 and CD-80 with high affinity selectivity. The primary objectives of this analysis were assess the pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity in patients advanced solid tumors. Methods: Data collected from Phase 1 study (NCT01693562) designed evaluate safety, tolerability, PK following 0.1, 0.3, 1.0, 3.0, 10 mg/kg every 2 weeks (Q2W) 15 3 (Q3W) intravenous doses MEDI4736. A total 377 provided...

CD11c is a dendritic cell marker in humans, which potentially induces cytotoxic effect on lymphoma cells. Forkhead boxP3 (FOXP3) regulator of T lymphocyte the microenvironment lymphoma. The principal objective this study was to determine whether tumors' expressions and FOXP3 are predictive clinical outcomes diffuse large B-cell (DLBCL) patients receiving treatment with rituximab, cyclophosphamide, anthracycline, vincristine, prednisone (R-CHOP) combination chemotherapy. population consisted...

Ectomesenchymal chondromyxoid tumor (ECMT) is a rare tumor, exclusively arising in the anterior tongue. Thirty-eight cases have been reported English literature. It usually presents as sessile protrusion and shows round to spindle cells embedded myxoid chondroid stroma. Tumor are almost always positive for polyclonal glial fibrillary acidic protein (GFAP). We report our experience recent treatment of case ECMT, third 3 years. The mass tongue revealed characteristic morphologic features ECMT...

Objectives This study was designed to evaluate the usefulness of intra‐operative frozen section for evaluation microscopic extrathyroidal extension ( ETE ) in papillary thyroid carcinoma PTC ). Design Retrospective cohort study. Setting Dong‐A University Medical Center, Busan, Korea. Participants Three hundred and sixty‐four patients who underwent surgery from January 2000 December 2010 with confined one unilateral lobe as diagnosed using preoperative ultrasonography were enrolled. Main...

Angiomatosis refers to a rare condition of large hamartomatous vascular lesions that extensively affect region the body or several different tissue types in contiguous way. Several cases have been reported mediastinum. We experienced histologically proven case mediastinal angiomatosis 56-year-old woman was incidentally detected as multiple conglomerated masses mimicking metastatic lymph nodes on chest radiography. Despite its rareness, our emphasizes pathologists and radiologists need be...

Objectives Biobanking plays an important role in future research. Assessment and control of the preanalytical variables biobanked tissues are fundamentals for optimal use biospecimens. Methods Forty-five colorectal cancer (CRC) stored at −80°C Bio-Resource Bank were evaluated to define influence cold ischemia time (CIT) storage period (SP) on DNA quality tissues. Three CITs (less than 30 minutes (CIT-1), 30–45 (CIT-2), 45–60 (CIT-3)) three SPs 1 year (SP-1), 2–3 years (SP-2), 4–5 (SP-3))...

Inflammatory myofibroblastic tumors (IMTs) are rare. They characterized by spindle cell proliferation with a varying degree of inflammatory infiltration. IMT can occur in any anatomic location but has been reported the lung, mesentery, and omentum, mainly children or young adults. It rarely occurs pancreas is often difficult to distinguish from other tumors, including some malignant ones. Therefore, it be challenging make radiological diagnosis IMT. Here, we present case that occurred head...

Primary ovarian carcinoid tumors are rare well-differentiated neuroendocrine classified as monodermal teratomas. They usually occur in perimenopausal woman and accompanied with mature cystic teratoma or mucinous tumors. The diagnosis may be supported by the clinical presentation of syndromes such flushing, diarrhea, chronic constipation. Here, we report on case a 51-year-old female surgically confirmed primary carcinoid, describe MRI features tumor, correlate them pathological findings.

Fibrin-associated large B-cell lymphoma (FA-LBCL) is an extremely rare subtype of LBCL that consists microscopic aggregates atypical B cells in the background fibrin. Here, we report first case FA-LBCL Korea. A 57-year-old male presented with a amount thrombus thoracic aorta during follow-up for graft replacement thoracoabdominal 8 years prior. The removed thrombus, measuring 4.3 × 3.1 cm, histologically exhibited eosinophilic fibrinous material several small clusters lymphoid at periphery....

Background: Patients with resectable colorectal lung oligometastasis (CLOM) demonstrate a heterogeneous oncological outcome.However, the parameters for predicting tumor aggressiveness have not yet been fully investigated in CLOM.This study was performed to determine prognostic value of histological growth patterns patients who underwent surgery CLOM.Methods:The included 92 were diagnosed CLOM among first resection cases.CLOMs grow according three patterns: aerogenous, pushing, and...