A5069009850- Influenza Virus Research Studies
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
- Epigenetics and DNA Methylation
- Long-Term Effects of COVID-19
- Herpesvirus Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral gastroenteritis research and epidemiology
- MicroRNA in disease regulation
- COVID-19 epidemiological studies
- Hepatitis Viruses Studies and Epidemiology
- Animal Disease Management and Epidemiology
- Hepatitis B Virus Studies
- Cancer-related gene regulation
- Helicobacter pylori-related gastroenterology studies
- Antibiotic Resistance in Bacteria
- Urinary Tract Infections Management
- Food Quality and Safety Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Immune Response and Inflammation
- Viral Infections and Vectors
- Streptococcal Infections and Treatments
Korea University
2016-2025
Ansan University
2014-2025
International Vaccine Institute
2024-2025
Samsung (United States)
2022-2025
Catholic University of Korea
2013-2024
Korea University Medical Center
2006-2024
Chonnam National University Hwasun Hospital
2024
National Health Insurance Service Ilsan Hospital
2020
Hanyang University
2020
GlaxoSmithKline (Belgium)
2019
Abstract Background This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis septic shock diagnosed according to Third International Consensus Definitions for Sepsis Septic Shock (Sepsis-3). Methods Serum levels IL-6, PTX3, PCT were measured 142 enrolled subjects (51 sepsis, 46 shock, 45 as controls). Follow-up IL-6 PTX3 initial within 24 h hospital discharge. Optimal cut-off values determined prognostic...
Background. The largest outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) outside the occurred in South Korea 2015 and resulted 186 laboratory-confirmed infections, including 36 (19%) deaths. Some hospitals were considered epicenters infection voluntarily shut down most their operations after nearly half all transmissions hospital settings. However, ways that MERS-CoV is transmitted healthcare settings are not well defined.
Memory T cells contribute to rapid viral clearance during re-infection, but the longevity and differentiation of SARS-CoV-2-specific memory remain unclear. Here we conduct ex vivo assays evaluate CD4+ CD8+ cell responses in COVID-19 convalescent patients up 317 days post-symptom onset (DPSO), find that are maintained study period regardless severity COVID-19. In particular, observe sustained polyfunctionality proliferation capacity cells. Among detected by activation-induced markers,...
Background. Although Middle East Respiratory Syndrome coronavirus (MERS-CoV) is characterized by a risk of nosocomial transmission, the detailed mode transmission and period virus shedding from infected patients are poorly understood. The aims this study were to investigate potential role environmental contamination MERS-CoV in healthcare settings define viable MERS patients.
The herpes zoster subunit vaccine (HZ/su), consisting of varicella-zoster virus glycoprotein E (gE) and AS01B Adjuvant System, was highly efficacious in preventing the ZOE-50 ZOE-70 trials. We present immunogenicity results from those Participants (ZOE-50: ≥50; ZOE-70: ≥70 years age) received 2 doses HZ/su or placebo, months apart. Serum anti-gE antibodies CD4 T cells expressing ≥2 4 activation markers assessed (CD42+) after stimulation with gE-peptides were measured subcohorts for humoral...
BackgroundVaccination has helped to mitigate the COVID-19 pandemic. Ten traditional and novel vaccines have been listed by World Health Organization for emergency use. Additional alternative approaches may better address ongoing vaccination globally, where there remains an inequity in vaccine distribution. GBP510 is a recombinant protein vaccine, which consists of self-assembling, two-component nanoparticles, displaying receptor-binding domain (RBD) highly immunogenic array.MethodsThis...
Background: From May to July 2015, the Republic of Korea experienced largest outbreak Middle East respiratory syndrome (MERS) outside Arabian Peninsula.A total 186 patients, including 36 deaths, had been diagnosed with MERS-coronavirus (MERS-CoV) infection as September 30th, 2015.Materials and Methods: We obtained information patients who were confirmed have MERS-CoV infection.MERS-CoV was using real-time reverse-transcriptase polymerase chain reaction assay. Results:The median age 55 years...
The lack of an appropriate preclinical model metabolic dysfunction-associated steatotic liver disease (MASLD) that recapitulates the whole spectrum impedes exploration pathophysiology and development effective treatment strategies. Here, we develop a mouse (Streptozotocin with high-fat diet, STZ + HFD) gradually develops fatty liver, steatohepatitis (MASH), hepatic fibrosis, hepatocellular carcinoma (HCC) in context dysfunction. transcriptomic features HFD mice closely reflect those patients...
This survey was performed to assess the level of influenza vaccine coverage, understand driving forces and barriers vaccination determine interventions for following year in Korean population.A national sample 1720 community dwelling adults age 18 older were surveyed by individual visits during April 2005. Demographics, state vaccination, reasons or non-vaccination perceptions on vaccinations asked questionnaire.Influenza coverage general population high risk group 34.3% 61.3%, respectively....
A new drug blocks platelet aggregation by interacting with the integrin receptor differently from current drugs that cause adverse side effects.
To evaluate the effects of transfusions in patients with severe sepsis and septic shock on mortality.Propensity-matched analysis a prospective observational database (April 2005 to February 2009).Twenty-two medical surgical intensive care units 12 teaching hospitals Korea.One thousand fifty-four community-acquired shock.None.Of 1,054 patients, 407 (38.6%) received blood transfusion. The mean pretransfusion hemoglobin level was 7.7 ± 1.2 g/dL. Transfused had higher 28-day in-hospital...
According to recent studies, patients with COVID-19 have different feature characteristics on chest X-ray (CXR) than those other lung diseases. This study aimed at evaluating the layer depths and degree of fine-tuning transfer learning a deep convolutional neural network (CNN)-based screening in CXR identify efficient strategies. The images used this were collected from publicly available repositories, classified into three classes: COVID-19, pneumonia, normal. To evaluate effect same CNN...
The Korean Society of Infectious Diseases has been regularly developing guidelines for adult immunization since 2007. In 2023, the following seven vaccines were revised: influenza, herpes zoster, pneumococcal, tetanus-diphtheria-pertussis (Tdap), human papillomavirus (HPV), meningococcal, and rabies vaccines. For influenza vaccine, a recommendation enhanced elderly was added. zoster recombinant vaccine pneumococcal current status 15-valent conjugate 20-valent PCV described. Tdap possibility...
Gastrokine 1 (GKN1) functions to protect the gastric antral mucosa and promotes healing by facilitating restoration proliferation after injury. GKN1 is downregulated in Helicobacter pylori-infected epithelial cells loss of expression closely associated with carcinogenesis, but underlying mechanisms tumor-suppressing effects remain largely unknown.AGS, MKN1, MKN28 cancer HFE-145 immortalized non-neoplastic mucosal were transfected or shGKN1. We conducted molecular functional studies miR-185...