A5014137251- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Hepatitis C virus research
- Neuropeptides and Animal Physiology
- HIV/AIDS drug development and treatment
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Bariatric Surgery and Outcomes
- Diabetes and associated disorders
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- HIV Research and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Dietary Effects on Health
- HIV/AIDS Research and Interventions
- Neuroendocrine regulation and behavior
- Autoimmune and Inflammatory Disorders Research
- Receptor Mechanisms and Signaling
- HIV-related health complications and treatments
- Systemic Lupus Erythematosus Research
- Diabetes Management and Research
- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
University of Zurich
2016-2025
University Hospital Frankfurt
2011-2024
Goethe University Frankfurt
2011-2024
Center for Rheumatology
2023
Frequentis (Austria)
2022
Swiss Integrative Center for Human Health
2011-2021
Heidelberg University
2007-2021
University Hospital Heidelberg
2006-2021
University of Calgary
2015-2020
Kantonsspital Baselland
2010-2020
Roux-en-Y gastric bypass is the most effective therapy for morbid obesity. This study investigated how affects intake of and preference high-fat food in an experimental (rat) within a trial setting (human). Proportion dietary fat patients was significantly lower 6 yr after surgery compared with vertical-banded gastroplasty ( P = 0.046). Gastric reduced total caloric < 0.001) increased standard low-fat chow consumption sham controls rats. Compared sham-operated rats, rats displayed much...
The SINGLE study was a randomized, double-blind, noninferiority that evaluated the safety and efficacy of 50 mg dolutegravir + abacavir/lamivudine versus efavirenz/tenofovir/emtricitabine in 833 ART-naive HIV-1 participants. Of randomized participants, 71% arm 63% maintained viral loads <50 copies per milliliter through W144 (P = 0.01). Superior primarily driven by fewer discontinuations due to adverse events [dolutegravir arm, 16 (4%); 58 (14%)] [corrected]. No treatment-emergent integrase...
Tenofovir (TDF) is an adenosine nucleotide analogue that has been approved for the treatment of HIV-1 infection. It also shows activity against hepatitis B virus (HBV) in patients with or without lamivudine (LAM)-associated mutations. Development clinical virological HBV breakthrough during TDF therapy not reported so far. The aim this study was to analyse polymerase (pol) from HIV/HBV-coinfected detectable serum levels DNA longer than 6 months.The pol sequenced 43 patient's before and...
Objective To analyse the immunological and virological effects of treatment interruptions in HIV-1-infected patients with failure multidrug-resistant virus. Methods Drug susceptibility was assessed using Antivirogram genotypic analysis based on population clonal sequencing for 48 who had interrupted (≥ 2 months). Results Treatment interruption resulted viral load increases (mean 0.7 log10 copies/ml;P = 0.0001) CD4 cell count decreases 89 × 106 cells/l;P 0.0001). A complete shift to wild-type...
Twenty-one adult patients were randomised to receive ghrelin on days 1 and 8 placebo 4 11 or vice versa, given intravenously over a 60-min period before lunch: 10 received 2 microg kg(-1) (lower-dose) ghrelin; (upper-dose) ghrelin. Active total ghrelin, growth hormone (GH), insulin-like factor levels monitored at baseline (4-5 day 1), during treatment days, end of study (day 17/18). Drug-related adverse events (assessed by NCI-CTC-toxicity criteria cardiac examination) did not differ between...
Sepiapterin reductase deficiency (SRD) is an under-recognized levodopa-responsive disorder. We describe clinical, biochemical, and molecular findings in a cohort of patients with this treatable condition. aim to improve awareness the phenotype available diagnostic therapeutic strategies reduce delayed diagnosis or misdiagnosis, optimize management, understanding pathophysiologic mechanisms.Forty-three individuals SRD were identified from 23 international medical centers. The treatment...
AimsThe deacetylase sirtuin 1 (Sirt1) exerts beneficial effects on lipid metabolism, but its roles in plasma LDL-cholesterol regulation and atherosclerosis are controversial.Thus, we applied the pharmacological Sirt1 activator SRT3025 a mouse model of hepatocyte culture. Methods resultsApolipoprotein E-deficient (Apoe 2/2 ) mice were fed high-cholesterol diet (1.25% w/w) supplemented with (3.18 g kg 21 diet) for 12 weeks.In vitro, drug activated wild-type protein, not activation-resistant...
Roux-en-Y gastric bypass (RYGB) reduces body weight and cardiovascular mortality in morbidly obese patients. Glucagon-like peptide-1 (GLP-1) seems to mediate the metabolic benefits of RYGB partly a loss-independent manner. The present study investigated rats patients whether obesity-induced endothelial high-density lipoprotein (HDL) dysfunction is rapidly improved after via GLP-1-dependent mechanism.Eight days diet-induced rats, higher plasma levels bile acids GLP-1 were associated with...
Background and Aims Roux-en-Y gastric bypass (RYGB) leads to a rapid remission of type 2 diabetes mellitus (T2DM), but the underlying mode action remains incompletely understood. L-cell derived gut hormones such as glucagon-like peptide-1 (GLP-1) peptide YY (PYY) are thought play central role in anti-diabetic effects RYGB; therefore, an improved understanding intestinal endocrine adaptability is considered pivotal. Methods The full rostrocaudal extension was analyzed rats after RYGB...