A5012742517- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Sirtuins and Resveratrol in Medicine
- Atrial Fibrillation Management and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrest and Resuscitation
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Cardiac Valve Diseases and Treatments
- scientometrics and bibliometrics research
- Meta-analysis and systematic reviews
- Angiogenesis and VEGF in Cancer
- Cardiovascular Effects of Exercise
- Mitochondrial Function and Pathology
- Heart Failure Treatment and Management
- Fatty Acid Research and Health
- Thermoregulation and physiological responses
- Cardiovascular Disease and Adiposity
- Cardiomyopathy and Myosin Studies
- Protease and Inhibitor Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Cardiac Imaging and Diagnostics
- PARP inhibition in cancer therapy
University Hospital of Zurich
2013-2024
Zurich Heart House
2014-2024
GZO Spital Wetzikon
2013-2024
Regional Health
2024
University of Zurich
2010-2022
Leipzig Heart Institute
2020
KLE Society Hospital
2018
Sir Ganga Ram Hospital
2018
Cardiovascular Research Center
2017
Swiss Integrative Center for Human Health
2010-2013
Aging | doi:10.18632/aging.100162. Sokrates Stein, Nicola Schäfer, Alexander Breitenstein, Christian Besler, Stephan Winnik, Christine Lohmann, Kathrin Heinrich, Chad E. Brokopp, Christoph Handschin, Ulf Landmesser, Felix C. Tanner, Thomas F. Lüscher, M. Matter
AimsAldosterone plays a crucial role in cardiovascular disease. ‘Systemic’ inhibition of its mineralocorticoid receptor (MR) decreases atherosclerosis by reducing inflammation and oxidative stress. Obesity, an important risk factor, is inflammatory disease associated with increased plasma aldosterone levels. We have investigated the ‘endothelial’ MR obesity-induced endothelial dysfunction, earliest stage atherogenesis.
AimsCollagen degradation in atherosclerotic plaques with thin fibrous caps renders them more prone to rupture. Fibroblast activation protein (FAP) plays a role arthritis and tumour formation through its collagenase activity. However, the significance of FAP thin-cap human fibroatheromata remains unknown.
AimsThe deacetylase sirtuin 1 (Sirt1) exerts beneficial effects on lipid metabolism, but its roles in plasma LDL-cholesterol regulation and atherosclerosis are controversial.Thus, we applied the pharmacological Sirt1 activator SRT3025 a mouse model of hepatocyte culture. Methods resultsApolipoprotein E-deficient (Apoe 2/2 ) mice were fed high-cholesterol diet (1.25% w/w) supplemented with (3.18 g kg 21 diet) for 12 weeks.In vitro, drug activated wild-type protein, not activation-resistant...
This study sought to examine the effects and underlying mechanisms of systemic VEGF inhibition in experimental atherosclerosis aortic endothelial cells.Pharmacological vascular growth factor (VEGF), a major mediator angiogenesis, has become widely applied treatment certain cancers multiple ocular diseases including age-related macular degeneration. However, recent clinical trials raise concern for adverse effects, prompting Food Drug Administration revoke approval bevacizumab metastatic...
AimsExtracts from pine tree bark containing a variety of flavonoids have been used in traditional medicine. Pycnogenol is proprietary extract the French maritime (Pinus pinaster ssp. atlantica) that exerts antioxidative, anti-inflammatory, and anti-platelet effects. However, effects on endothelial dysfunction, precursor atherosclerosis cardiovascular events, remain still elusive.
Through a 4-year follow-up of the abstracts submitted to European Society Cardiology Congress in 2006, we aimed at identifying factors predicting high-quality research, appraising quality peer review and editorial processes, thereby revealing potential ways improve future review, work. METHODS AND RESULTS All 2006 were assessed for acceptance, presentation format, average reviewer rating. Accepted rejected studies followed 4 years. Multivariate regression analyses representative selection...
Objective Bone Morphogenetic Protein-4 (BMP-4) and Extracellular-Signal Regulated Kinases (ERK) play crucial roles in vascular diseases. Here, we demonstrate that BMP-4 not only signals through the classical Smad cascade but also activates ERK phosphorylation as an alternative pathway human umbilical vein endothelial cells (HUVEC) pathways communicate signal crosstalk.
Epidemiological studies report an inverse association between plant-derived dietary α-linolenic acid (ALA) and cardiovascular events. However, little is known about the mechanism of this protection. We assessed cellular molecular mechanisms ALA (flaxseed) on atherosclerosis in a mouse model.Eight-week-old male apolipoprotein E knockout (ApoE(-/-)) mice were fed 0.21 % (w/w) cholesterol diet for 16 weeks containing either high [7.3 (w/w); n = 10] or low content [0.03 10]. Bioavailability,...
Sirt3 is a mitochondrial NAD+-dependent deacetylase that governs metabolism and reactive oxygen species homeostasis. deficiency has been reported to accelerate the development of metabolic syndrome. However, role in atherosclerosis remains enigmatic. We aimed investigate whether affects atherosclerosis, plaque vulnerability, Low-density lipoprotein receptor knockout (LDLR −/−) LDLR/Sirt3 double-knockout (Sirt3 −/− LDLR mice were fed high-cholesterol diet (1.25 % w/w) for 12 weeks....
We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared other cardiovascular and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). further wanted to determine incidence HF events and its consequences in these patient populations.International retrospective Postgraduate Course Heart Failure registry for COVID-19 CArdioVascular dyslipidaemia) was performed 28 centres from 15 countries (PCHF-COVICAV). The primary...
Arterial hypertension is an important risk factor for cerebrovascular diseases, such as transient ischemic attacks or stroke, and represents a major global health issue. The effects of on cerebral blood flow, particularly at the microvascular level, remain unknown.Using spontaneously hypertensive rat (SHR) model, we examined cortical hemodynamic responses whisker stimulation applying multimodal imaging approach (multiwavelength spectroscopy, laser speckle imaging, 2-photon microscopy). We...
Abstract Aims Sirtuin 3 (Sirt3) is a mitochondrial, nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that reduces oxidative stress by activation of superoxide dismutase 2 (SOD2). Oxidative enhances arterial thrombosis. This study investigated the effects genetic Sirt3 deletion on thrombosis in mice an inflammatory setting and assessed clinical relevance these findings patients with ST-elevation myocardial infarction (STEMI). Methods results Using laser-induced carotid model...
AimsHomeobox (Hox) proteins are transcriptional regulators in embryonic patterning, cell differentiation, proliferation, and migration vertebrates invertebrates. A growing body of evidence suggests that Hox involved endothelial regulation. We have shown earlier HoxB5 upregulates vascular growth factor receptor-2 thereby contributes to enhanced precursor differentiation. Here we aim elucidate the role angiogenesis.
Aims Epidemiological studies report an inverse association between plant-derived dietary α-linolenic acid (ALA) and cardiovascular events. However, little is known about the mechanism of this protection. We assessed cellular molecular mechanisms ALA (flaxseed) on atherosclerosis in a mouse model. Methods results Eight-week-old male apolipoprotein E knockout (ApoE(-/-)) mice were fed 0.21 % (w/w) cholesterol diet for 16 weeks containing either high [7.3 (w/w); n = 10] or low content [0.03...
Sirtuin 3 (Sirt3) is an NAD+-dependent mitochondrial deacetylase associated with superoxide dismutase 2 (SOD2)-mediated protection from oxidative stress. We have reported accelerated weight gain and impaired metabolic flexibility in atherosclerotic Sirt3 −/− mice. Oxidative stress a hallmark of endothelial dysfunction. Yet, the role this context remains unknown. Thus, we aimed to unravel effects endogenous on function Knockdown human aortic cells (HAEC) increased intracellular accumulation,...
Abstract Background Persistent left superior vena cava (PLSVC) is a rare venous anomaly, affecting 0.3–0.5% of the general population. Cardiac resynchronization therapy (CRT) implantation in patients with PLSVC challenging due to complex anatomy. Moreover, data on CRT this patient population scarce. Our aim was report series and focusing challenges pitfalls. Methods Electronic medical databases at University Heart Centers Zurich, Switzerland, Lübeck, Germany, were screened for individuals...
Abstract Aims Pulmonary vein isolation (PVI) for catheter ablation of atrial fibrillation (AF) is a time-demanding procedure. High-power short-duration (HPSD) protocols and high-density mapping catheters have recently been introduced to clinical practice. We investigated the impact HPSD on procedural timing, efficacy, safety by comparing different standardized set-ups. Methods results Three electrophysiology (EP) laboratory set-ups were analysed: (i) circular with 30/35 W guided an index...
The growing population of left ventricular assist device (LVAD)-supported patients increases the probability an LVAD- supported patient hospitalized in internal or surgical wards with certain expected related, and patient-device interaction complication as well any other comorbidities requiring hospitalization. In this third part trilogy on management LVAD-supported for non-LVAD specialist healthcare provider, definitions structured approach to are presented including blood pressure...