A5019077055- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Platelet Disorders and Treatments
- Acute Ischemic Stroke Management
- Fatty Acid Research and Health
- Cardiac Arrhythmias and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Blood properties and coagulation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Neurological Disease Mechanisms and Treatments
- Diagnosis and Treatment of Venous Diseases
- Blood Pressure and Hypertension Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lipid metabolism and disorders
Kantonsspital Baden
2016-2025
University of Zurich
2016-2025
University Medical Center of the Johannes Gutenberg University Mainz
2025
Johannes Gutenberg University Mainz
2025
University Hospital of Zurich
2015-2024
Ferioli & Gianotti (Italy)
2024
Kantonsspital Frauenfeld
2023
University of Lausanne
2023
University Centre of Legal Medicine
2023
St Thomas' Hospital
2023
It is uncertain whether intensified heart failure therapy guided by N-terminal brain natriuretic peptide (BNP) superior to symptom-guided therapy.To compare 18-month outcomes of BNP-guided vs therapy.Randomized controlled multicenter Trial Intensified Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) 499 patients aged 60 years or older with systolic (ejection fraction < = 45%), New York Association (NYHA) class II greater, prior hospitalization for within...
Summary There is a need to validate risk assessment tools for hospitalised medical patients at of venous thromboembolism (VTE). We investigated whether predefined cut-off the Geneva Risk Score, as compared Padua Prediction accurately distinguishes low-risk from high-risk regardless use thromboprophylaxis. In multicentre, prospective Explicit ASsessment Thromboembolic RIsk and Prophylaxis Medical PATients in SwitzErland (ESTIMATE) cohort study, 1,478 were enrolled whom 637 (43%) did not...
BackgroundSince the beginning of coronavirus disease 2019 (COVID-19) pandemic, there has been increasing urgency to identify pathophysiological characteristics leading severe clinical course in patients infected with acute respiratory syndrome 2 (SARS-CoV-2). Human leukocyte antigen alleles (HLA) have suggested as potential genetic host factors that affect individual immune response SARS-CoV-2. We sought evaluate this hypothesis by conducting a multicenter study using HLA...
CANTOS reported reduced secondary atherothrombotic events in patients with residual inflammatory risk treated the inhibitory anti-IL-1β antibody, Canakinumab. Yet, mechanisms that underlie this benefit remain elusive. Recent work has implicated formation of neutrophil extracellular traps (NETosis) arterial thrombosis. Hence, present study explored potential link between IL-1β, NETs, and tissue factor (TF)—the key trigger coagulation cascade—in atherothrombosis. To end, ST-elevation...
Abstract Aims We aimed to investigate the association of clinically overt and silent brain lesions with cognitive function in atrial fibrillation (AF) patients. Methods results enrolled 1227 AF patients a prospective, multicentre cohort study (Swiss-AF). Patients underwent standardized magnetic resonance imaging (MRI) at baseline after 2 years. quantified new small non-cortical infarcts (SNCIs) large or cortical (LNCCIs), white matter (WML), microbleeds (Mb). Clinically, were defined as...
Background Women are overrepresented among individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown. Aim We assessed the sex gender in a Swiss population. Method Our multicentre prospective cohort study included 2,856 (46% women, mean age 44.2 ± 16.8 years) outpatients hospitalised patients PCR-confirmed infection. Results Among...
Treatment with vitamin K antagonists (VKAs) has been linked to worsening of kidney function in patients atrial fibrillation (AF).
The existence of a phenomenon rebound hypercoagulability after cessation oral anticoagulant therapy is controversial. sensitive procoagulant markers for in vivo thrombin and fibrin formation are potential tools the reassessment presence such phenomenon. We examined 19 patients anticoagulated 6 ± 2 months (SD, range 3–12) because venous thromboembolism or myocardial infarction as follows: twice during stable, anticoagulation (INR 3.1–3.7) then on days 1, 2, 3, 4, 5, 7, 9, 11, 13, 15 >30...
The authors evaluated a site-independent telemedicine system. Telemedicine may be limited by the need for fixed connectivity. Wireless and technologies eliminate this limitation. Twenty-five stroke patients underwent evaluations remote bedside examiners. Ten of 15 (67%) NIH Stroke Scale 9 11 (82%) Modified items showed excellent interrater reliability. Spearman correlations were ≥0.93. This Internet system is reliable valid. Further studies should assess its use in acute stroke.
Objective— Plant-derived α-linolenic acid (ALA) may constitute an attractive cardioprotective alternative to fish-derived n -3 fatty acids. However, the effect of dietary ALA on arterial thrombus formation remains unknown. Methods and Results— Male C57Bl/6 mice were fed a high-ALA or low-ALA diet for 2 weeks. Arterial was delayed in compared with those (n=7; P <0.005). Dietary impaired platelet aggregation collagen thrombin (n=5; <0.005) decreased p38 mitogen-activated protein kinase...
Several studies found that patients with atrial fibrillation (AF) have an increased risk of cognitive decline and dementia over time. However, the magnitude problem, associated factors underlying mechanisms remain unclear.This article describes design methodology Swiss Atrial Fibrillation (Swiss-AF) Cohort Study, a prospective multicentre national cohort study 2400 across 13 sites in Switzerland. Eligible must documented AF. Main exclusion criteria are inability to provide informed consent...
Aging is an established risk factor for stroke; genes regulating longevity are implicated in the pathogenesis of ischaemic stroke where to date, therapeutic options remain limited. The blood-brain barrier (BBB) crucially involved ischaemia/reperfusion (I/R) brain injury thus representing attractive target developing novel agents. Given role endothelial cells BBB, we hypothesized that endothelial-specific expression recently described gene SIRT6 may exhibit protective properties stroke.SIRT6...