A5037157567- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Biosensors and Analytical Detection
- Herpesvirus Infections and Treatments
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- Nail Diseases and Treatments
- Plant Virus Research Studies
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
- Viral Infections and Vectors
- Influenza Virus Research Studies
- Plant Pathogens and Fungal Diseases
- vaccines and immunoinformatics approaches
- Bacillus and Francisella bacterial research
- Advanced biosensing and bioanalysis techniques
- Acne and Rosacea Treatments and Effects
- Fungal Infections and Studies
- Poxvirus research and outbreaks
- Toxoplasma gondii Research Studies
- Animal Virus Infections Studies
- Bacteriophages and microbial interactions
University of Cambridge
2008-2024
Humboldt-Universität zu Berlin
2020-2024
Charité - Universitätsmedizin Berlin
2018-2024
Freie Universität Berlin
2020-2024
German Center for Infection Research
2020-2024
Institute of Virology of the Slovak Academy of Sciences
2022-2023
University of Veterinary Medicine Vienna
2023
Vivantes Klinikum
2023
Wildlife Conservation Society
2023
Deutsche Gesellschaft für Internationale Zusammenarbeit
2023
Antigenic and genetic analysis of the hemagglutinin â¼13,000 human influenza A (H3N2) viruses from six continents during 2002â2007 revealed that there was continuous circulation in east Southeast Asia (E-SE Asia) via a region-wide network temporally overlapping epidemics temperate regions were seeded this each year. Seed strains generally first reached Oceania, North America, Europe, later South America. This evidence suggests once leave E-SE Asia, they are unlikely to contribute...
Two elementary parameters for quantifying viral infection and shedding are load whether samples yield a replicating virus isolate in cell culture. We examined 25,381 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Germany, including 6110 from test centers attended by presymptomatic, asymptomatic, mildly symptomatic (PAMS) subjects, 9519 who were hospitalized, 1533 B.1.1.7 lineage infections. The the youngest subjects was lower than that older 0.5 (or fewer) log
We introduce the antibody landscape, a method for quantitative analysis of antibody-mediated immunity to antigenically variable pathogens, achieved by accounting antigenic variation among pathogen strains. generated landscapes study immune profiles covering 43 years influenza A/H3N2 virus evolution 69 individuals monitored infection over 6 and 225 pre- postvaccination. Upon vaccination, titers increased broadly, including previously encountered viruses far beyond extent cross-reactivity...
Abstract As children are under-represented in current studies aiming to analyse transmission of SARS-coronavirus 2 (SARS-CoV-2), their contribution is unclear. Viral load, as measured by RT-PCR, can inform considerations regarding transmission, especially if existing knowledge viral load other respiratory diseases taken into account. RT-PCR threshold cycle data from 3303 patients who tested positive for SARS-CoV-2 (out 77,996 persons total, drawn across Germany) were analysed examine the...
Smallpox eradication, coordinated by the WHO and certified 40 years ago, led to cessation of routine smallpox vaccination in most countries. It is estimated that over 70% world's population no longer protected against smallpox, through cross-immunity, closely related orthopox viruses such as monkeypox. Monkeypox now a re-emerging disease. endemic yet unconfirmed animal reservoirs sub-Saharan Africa, while its human epidemiology appears be changing. small animals imported from Ghana exotic...
The spectrum of viruses in insects is important for subjects as diverse public health, veterinary medicine, food production, and biodiversity conservation. traditional interest vector-borne diseases humans livestock has drawn the attention virus studies to hematophagous insect species. However, these represent only a tiny fraction broad diversity Hexapoda, most speciose group animals. Here, we systematically probed negative strand RNA largest representative collection transcriptomes from...
Viking smallpox diversity Humans have a notable capacity to withstand the ravages of infectious diseases. Smallpox killed millions people but drove Jenner's invention vaccination, which eventually led annihilation this virus, declared in 1980. To investigate history smallpox, Mühlemann et al. obtained high-throughput shotgun sequencing data from 1867 human remains ranging >31,000 150 years ago (see Perspective by Alcamí). Thirteen positive samples emerged, 11 were northern European Age...
During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, multiple variants escaping preexisting immunity emerged, causing reinfections of previously exposed individuals. Here, we used antigenic cartography to analyze patterns cross-reactivity among 21 and 15 groups human sera obtained after primary infection with 10 different or messenger RNA (mRNA)–1273 mRNA-1273.351 vaccination. We found differences pre-Omicron caused by substitutions at spike-protein positions...
Variant BA.2.86 and its descendant, JN.1, of SARS-CoV-2 are rising in incidence across Europe globally. We isolated recent BA.2.86, EG.5, XBB.1.5 earlier variants. tested live virus neutralisation sera taken September 2023 from vaccinated exposed healthy persons (n = 39). found clear escape against variants but no specific pronounced for or JN.1. Neutralisation corresponds to variant predominance may not be causative the upsurge JN.1 incidence.
In the early 1970s, a human influenza A/Port Chalmers/1/73 (H3N2)-like virus colonized European swine population. Analyses of A (H3N2) viruses isolated in The Netherlands and Belgium revealed that 1990s, antigenic drift had occurred, away from Chalmers/1/73, strain commonly used vaccines for pigs. Here we show Italian displayed genetic changes similar to those observed Northern same period. We cartography methods quantitative analyses evolution H3N2 clustered as seen viruses. Although has...
BackgroundSince the beginning of coronavirus disease 2019 (COVID-19) pandemic, there has been increasing urgency to identify pathophysiological characteristics leading severe clinical course in patients infected with acute respiratory syndrome 2 (SARS-CoV-2). Human leukocyte antigen alleles (HLA) have suggested as potential genetic host factors that affect individual immune response SARS-CoV-2. We sought evaluate this hypothesis by conducting a multicenter study using HLA...
In the emergency department (ED) setting, rapid testing for SARS-CoV-2 is likely associated with advantages to patients and healthcare workers, example, enabling early but rationale use of limited isolation resources. Most recently, several point-of-care antigen tests (AGTEST) became available. There a growing need data regarding their clinical utility performance in diagnosis infection real life setting EDs.We implemented AGTEST (here: Roche/SD Biosensor) all four adult one paediatric EDs...
Abstract We detected delayed and reduced antibody T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers 34 Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial additional immunizations the might become necessary.
During the SARS-CoV-2 pandemic, multiple variants escaping pre-existing immunity emerged, causing concerns about continued protection. Here, we use antigenic cartography to analyze patterns of cross-reactivity among a panel 21 and 15 groups human sera obtained following primary infection with 10 different or after mRNA-1273 mRNA-1273.351 vaccination. We find differences pre-Omicron caused by substitutions at spike protein positions 417, 452, 484, 501. Quantifying changes in response breadth...
Evolving SARS-CoV-2 variants and changing levels of pre-existing immunity require re-evaluation antigen-detecting rapid diagnostic test (Ag-RDT) performance. We investigated possible associations between Ag-RDT sensitivity various potential influencing factors, such as immunisation status viral variant, in symptomatic hospital employees.
Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) has developed substantial antigenic variability. As the majority of population now pre-existing immunity due to infection or vaccination, use experimentally generated animal immune sera can be valuable for measuring differences between virus variants. Here, we immunized Syrian hamsters by two successive infections with one nine SARS-CoV-2 Their were titrated against 16 variants, and resulting titers visualized using cartography....
Significance The majority of viral genomic sequences available today are fewer than 50 years old. Parvovirus B19 (B19V) is a ubiquitous human pathogen causing fifth disease in children, as well other conditions. By isolating B19V DNA from remains between ∼0.5 and 6.9 thousand old, we show that has been associated with humans for thousands years, which significantly longer previously thought. We also the virus evolving at rate an order magnitude lower estimated previously. Access to isolated...