A5011610803- Corrosion Behavior and Inhibition
- Hydrogen embrittlement and corrosion behaviors in metals
- Shoulder Injury and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Shoulder and Clavicle Injuries
- Concrete Corrosion and Durability
- Aluminum Alloy Microstructure Properties
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Orthopedic Surgery and Rehabilitation
- Metal and Thin Film Mechanics
- Anodic Oxide Films and Nanostructures
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Force Microscopy Techniques and Applications
- Non-Destructive Testing Techniques
- Breast Cancer Treatment Studies
- Cardiac electrophysiology and arrhythmias
- Nerve Injury and Rehabilitation
- Cardiac pacing and defibrillation studies
- Electrodeposition and Electroless Coatings
- Foot and Ankle Surgery
- Folate and B Vitamins Research
- Peptidase Inhibition and Analysis
Kantonsspital Baselland Standort Bruderholz
2021-2025
University of Basel
2023-2024
University Hospital of Bern
2005-2024
University of Bern
2019-2024
University Hospital of Basel
2024
Universitätsklinik Balgrist
2006-2024
Charité - Universitätsmedizin Berlin
2024
Schulthess-Klinik
2024
Solothurner Spitäler
2024
Swiss Federal Laboratories for Materials Science and Technology
2005-2022
2-D : two-dimensional 3-D : three-dimensional 5-FU : 5-fluorouracil ACE : angiotensin-converting enzyme ARB : angiotensin II receptor blocker ASE : American Society of Echocardiography BNP : B-type natriuretic peptide CABG : coronary artery bypass graft CAD :
Pertuzumab increases the rate of pathological complete response in preoperative context and overall survival among patients with metastatic disease when it is added to trastuzumab chemotherapy for treatment human epidermal growth factor receptor 2 (HER2)–positive breast cancer. In this trial, we investigated whether pertuzumab, adjuvant chemotherapy, improves outcomes HER2-positive early
It is uncertain whether intensified heart failure therapy guided by N-terminal brain natriuretic peptide (BNP) superior to symptom-guided therapy.To compare 18-month outcomes of BNP-guided vs therapy.Randomized controlled multicenter Trial Intensified Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) 499 patients aged 60 years or older with systolic (ejection fraction < = 45%), New York Association (NYHA) class II greater, prior hospitalization for within...
Purpose The purpose of this analysis was to investigate trastuzumab-associated cardiac adverse effects in breast cancer patients after completion (neo)adjuvant chemotherapy with or without radiotherapy. Patients and Methods Herceptin Adjuvant (HERA) trial is a three-group, multicenter, open-label randomized that compared 1 2 years trastuzumab given once every 3 weeks observation HER-2–positive cancer. Only who radiotherapy had normal left ventricular ejection fraction (LVEF ≥ 55%) were...
The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve function in patients with heart failure a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown.We randomly assigned 8256 (inpatients and outpatients) symptomatic chronic an fraction of 35% or less receive (using pharmacokinetic-guided doses 25 mg, 37.5 50 mg twice daily) placebo, addition standard heart-failure therapy. primary outcome was composite first event (hospitalization urgent...
Background Lapatinib (L) plus trastuzumab (T) improves outcomes for metastatic human epidermal growth factor 2–positive breast cancer and increases the pathologic complete response in neoadjuvant setting, but their role as adjuvant therapy remains uncertain. Methods In Adjuvant and/or Trastuzumab Treatment Optimization trial, patients with centrally confirmed early were randomly assigned to 1 year of T, L, sequence (T→L), or combination (L+T). The primary end point was disease-free survival...
Background: Patient-reported outcome measures have increasingly accompanied objective examination findings in the evaluation of orthopaedic interventions. Our was to determine whether a validated measure mental health (Short Form-36 Mental Component Summary [SF-36 MCS]) or tear severity on magnetic resonance imaging were more strongly associated with self-assessed shoulder pain and function patients symptomatic full-thickness rotator cuff tears. Methods: One hundred sixty-nine tears...
Purpose Women receiving trastuzumab with chemotherapy are at risk for trastuzumab-related cardiac dysfunction (TRCD). We explored the prognostic value of markers (troponins I and T, N-terminal prohormone brain natriuretic peptide [NT-proBNP]) to predict baseline susceptibility develop TRCD. examined whether development end points or significant left ventricular ejection fraction (LVEF) drop was associated markers' increases. Patients Methods Cardiac marker assessments were coupled LVEF...
The onset of pitting at single inclusions on aluminum 2024-T3 has been observed in the micrometer range by using a microelectrochemical cell order to study mechanisms which intermetallic particles, particularly AlCuMg and AlCuFeMn, induce localized corrosion. results showed that started only few within 200 mV (saturated calomel electrode, SCE) potential large scale measurements. Pit initiation lower potentials was found occur adjacent matrix inclusions. Measurements stopped were made during...
The onset of pitting corrosion at MnS inclusions on 304 stainless steel in 1 M NaCl was studied with and without applied mechanical stress use microelectrochemical cells. Polarization curves areas (100 μm diam) inclusion showed no potentials below that oxidation evolution; had effect the behavior. Areas containing five round about 4 size stable 400 mV; shifted potential to values were 150 mV more negative. measured large deep active pitting. Curves single large, shallow multiple current...
A combination of mathematical modeling and experiments on single MnS inclusions was used to investigate the role initiation pitting corrosion 304 stainless steel. Isolation in chloride-containing solutions with use microcapillaries as electrochemical cells showed that orientation inclusion played a significant pit initiation. Large, shallow failed initiate corrosion, while same inclusions, oriented narrow deep, consistently exhibited onset localized corrosion. The formation microcrevice...