A5044445574- Cardiac Valve Diseases and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Inflammatory mediators and NSAID effects
- Angiogenesis and VEGF in Cancer
- Cardiovascular Function and Risk Factors
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Arrhythmias and Treatments
- COVID-19 Clinical Research Studies
- Peripheral Artery Disease Management
- Cardiac pacing and defibrillation studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Arrest and Resuscitation
- Nitric Oxide and Endothelin Effects
- Vascular Procedures and Complications
- Antioxidant Activity and Oxidative Stress
- Cell Adhesion Molecules Research
University Hospital of Zurich
2015-2024
University of Zurich
2008-2023
Zurich Heart House
2016-2020
Deutsches Herzzentrum der Charité
2019
Segeberger Kliniken
2017-2018
St. Paul's Hospital
2016
Swiss Integrative Center for Human Health
2010-2015
Kantonsspital Baden
2011-2013
Czech Academy of Sciences, Institute of Physiology
2013
École Polytechnique Fédérale de Lausanne
2011
Transcatheter aortic valve replacement (TAVR) is being increasingly performed in patients with bicuspid stenosis (AS).This study sought to compare the procedural and clinical outcomes versus tricuspid AS from Bicuspid TAVR multicenter registry.Outcomes of 561 4,546 were compared after propensity score matching, assembling 546 pairs similar baseline characteristics. Procedural recorded according Valve Academic Research Consortium-2 criteria.Compared AS, had more frequent conversion surgery...
Few studies have evaluated the clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with bicuspid stenosis (AS). Particularly, limited data exist comparing results TAVR new-generation devices versus early-generation devices. This study sought to evaluate for AS early- and The Bicuspid Registry is an international multicenter enrolling consecutive undergoing between April 2005 May 2015. Of 301 patients, 199 (71.1%) were treated (Sapien XT [Edwards Lifesciences...
Cardiovascular events remain the leading cause of death in Western world. Atherosclerosis is most common underlying complication driven by low-density lipoproteins (LDL) disturbing vascular integrity. Carbamylation lysine residues, occurring primarily presence chronic kidney disease (CKD), may affect functional properties lipoproteins; however, its effect on endothelial function unknown. Low-density lipoprotein from healthy donors was isolated and carbamylated. Vascular reactivity after...
CANTOS reported reduced secondary atherothrombotic events in patients with residual inflammatory risk treated the inhibitory anti-IL-1β antibody, Canakinumab. Yet, mechanisms that underlie this benefit remain elusive. Recent work has implicated formation of neutrophil extracellular traps (NETosis) arterial thrombosis. Hence, present study explored potential link between IL-1β, NETs, and tissue factor (TF)—the key trigger coagulation cascade—in atherothrombosis. To end, ST-elevation...
The mammalian silent information regulator-two 1 (Sirt1) blunts the noxious effects of cardiovascular risk factors such as type 2 diabetes mellitus and obesity. Nevertheless, role Sirt1 in regulating expression tissue factor (TF), key trigger coagulation, arterial thrombus formation remains unknown.Human well mouse cell lines were used for vitro experiments, C57Bl/6 mice vivo procedures. inhibition by splitomicin or sirtinol enhanced cytokine-induced endothelial TF protein surface activity,...
Objective— Plant-derived α-linolenic acid (ALA) may constitute an attractive cardioprotective alternative to fish-derived n -3 fatty acids. However, the effect of dietary ALA on arterial thrombus formation remains unknown. Methods and Results— Male C57Bl/6 mice were fed a high-ALA or low-ALA diet for 2 weeks. Arterial was delayed in compared with those (n=7; P <0.005). Dietary impaired platelet aggregation collagen thrombin (n=5; <0.005) decreased p38 mitogen-activated protein kinase...
Aims: Long-term results of transcatheter aortic valve implantation (TAVI), in particular the incidence bioprosthetic failure (BVF), are uncertain.This study presents data derived from a long-term, structured follow-up programme self-expanding CoreValve device utilising standardised definitions and core lab adjudication performance. Methods results:The prospectively included all 152 patients who had undergone TAVI with up to December 2011 at Heart Center, Bad Segeberg, Germany.Late BVF (>30...
Background: Left atrial appendage occlusion (LAAO) is mostly performed by transesophageal echocardiography (TEE) guidance. Intracardiac (ICE) may be an alternative imaging modality for LAAO that precludes the need general anesthesia or sedation. Methods and Results: All consecutive single center, operator candidates were analyzed. Baseline clinical procedural characteristics in‐hospital outcomes compared between patients in whom a Watchman was implanted with ICE vs. TEE In 76 device deployed...
BackgroundImpaired re-endothelialization and stent thrombosis are a safety concern associated with drug-eluting stents (DES). PI3K/p110α controls cellular wound healing pathways, thereby representing an emerging drug target to modulate vascular homoeostasis after injury.
The lectin-like oxLDL receptor-1 (LOX-1) promotes endothelial uptake of oxidized low-density lipoprotein (oxLDL) and plays an important role in atherosclerosis acute coronary syndromes (ACS). However, its arterial thrombus formation remains unknown. We investigated whether LOX-1 a vivo at different levels using endothelial-specific transgenic mice (LOX-1TG) photochemical injury thrombosis model the carotid artery.In fed normal chow diet, time to occlusion was unexpectedly prolonged LOX-1TG...
Large-bore catheter aspiration embolectomy reduces thrombus burden and right ventricle strain improves haemodynamics after pulmonary embolism (PE). Sparse data are available for patients with high-risk PE contraindications to thrombolysis or failure, particularly if veno-arterial extracorporal membrane oxygenation (VA-ECMO) is required.All acute undergoing FlowTriever® percutaneous VA-ECMO circulatory support (or standby) at the University Hospital Zurich between April 2021 August 2022 were...
Summary Thrombus formation is determined by the balance between prothrombotic mediators and anti-thrombotic factors. High-density lipoprotein (HDL) from healthy subjects exerts properties. Whether this also case for HDL patients with stable coronary heart disease (CHD) or acute syndrome (ACS) unknown. In human aortic endothelial cells in culture, (50 μg/ml) (HS) inhibited thrombin-induced tissue factor (TF) expression activity, while CHD ACS did not. Similarly, only increased pathway...
The aim of this study was to assess the feasibility and early outcomes transcatheter aortic valve implantation (TAVI) in dysfunctional TAVI prostheses (redo TAVI).Nineteen redo procedures were performed between October 2011 November 2015 at two German centres. Mean age 78 years, 13 (68%) male, mean logistic EuroSCORE 32%. Median time elapsed since index 644 days (interquartile range 191-1,831). Failure mode prosthesis regurgitation (AR) 16 patients (n=12 paravalvular AR, n=3 combined...
To assess the effects of aging on arterial thrombus formation by comparing 2-year-old with 11-week-old C57Bl6 mice.Aging is a major risk factor for cardiovascular disease. In humans, assessing direct vascular homeostasis difficult because it occurs in presence other factors. Arterial thrombosis critical event diseases; however, not known whether per se promotes its occurrence. Mice represent an interesting system to address this issue they age without spontaneously developing Organ chamber...
The choice of optimal antithrombotic regimen after transcatheter aortic valve replace-ment (TAVR) remains a matter debate. objective this study was to compare both efficacy and safety outcomes based on the type therapy prescribed TAVR Methods: This is retrospective analysis 514 consecutive patients treated with either dual antiplate¬let (DAPT) (n = 315; 61.3%) or oral anticoagulation (OAC) plus clopidogrel 199; 38.7%) for minimum 3 months followed by antiplatelet monotherapy OAC only,...