A5051467665- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Infective Endocarditis Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Transplantation: Methods and Outcomes
- Tissue Engineering and Regenerative Medicine
- Coronary Artery Anomalies
- Cardiac tumors and thrombi
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrhythmias and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Pulmonary Hypertension Research and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Venous Thromboembolism Diagnosis and Management
- Trauma Management and Diagnosis
- Kawasaki Disease and Coronary Complications
- Vascular anomalies and interventions
- Sirtuins and Resveratrol in Medicine
- Cardiac pacing and defibrillation studies
University Hospital of Zurich
2018-2025
University Children's Hospital Zurich
2014-2024
Zurich Heart House
2021-2024
University of Zurich
2020-2023
The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and its shedding product [soluble LOX-1 (sLOX-1)] are implicated in atherosclerotic cardiovascular disease (ASCVD) pathogenesis. Herein, we examined the relationship of sLOX-1 with both fatal events plaque progression patients acute coronary syndromes (ACS).Plasma was assessed at baseline ACS chronic syndrome (CCS) prospectively recruited multicentre SPUM-ACS study, sex- age-matched healthy subjects serving as additional...
Decellularized pulmonary homografts (DPH) have shown excellent results for valve replacement. However, controlled multicentre studies are lacking to date.Prospective European trial evaluating DPH Matched comparison of bovine jugular vein (BJV) conduits and cryopreserved (CH) considering patient age, type heart defect previous procedures.In total, 121 patients (59 female) were prospectively enrolled (August 2014-December 2016), age 21.3 ± 14.4 years, diameter 24.4 2.8 mm. No adverse events...
Enhancing SIRT1 activity exerts beneficial cardiovascular effects. In diabetes, plasma levels are reduced. We aimed to investigate the therapeutic potential of chronic recombinant murine (rmSIRT1) supplementation alleviate endothelial and vascular dysfunction in diabetic mice (db/db).Left internal mammary arteries obtained from patients undergoing coronary artery bypass grafting with or without a diagnosis diabetes were assayed for protein levels. Twelve-week-old male db/db db/+ controls...
Decellularized aortic homografts (DAH) were introduced as a new option for valve replacement young patients.
Abstract OBJECTIVES Decellularized aortic homografts (DAH) may provide an additional valve replacement option for young patients due to their potential overcome the high early failure rate of conventional allogenic and xenogenic prostheses. METHODS A prospective, European Union-funded, single-arm, multicentre, safety study was conducted in 8 centres evaluating non-cryopreserved DAH replacement. RESULTS One hundred forty-four (99 male) were prospectively enrolled between October 2015 2018,...
Fueled by the global surge in aging, atherosclerotic cardiovascular disease reached pandemic dimensions putting affected individuals at enhanced risk of myocardial infarction, stroke, and premature death. Atherosclerosis is a systemic driven wide spectrum factors, including cholesterol, pressure, disturbed flow. Although all arterial beds encounter similar atherogenic milieu, development atheromatous lesions occurs discontinuously across vascular system. Indeed, internal mammary artery...
Early results from the prospective ESPOIR Trial have indicated excellent for pulmonary valve replacement using decellularized homografts (DPH).A 5-year analysis of patients was performed to provide an insight into midterm DPH performance. and Registry were matched with cryopreserved (CH) considering patient age, type heart defect previous procedures present overall experience DPH.A total 121 (59 female) prospectively enrolled (8/2014-12/2016), median age 16.5 years (interquartile range...
Abstract OBJECTIVES Decellularized aortic homografts (DAH) were introduced in 2008 as a further option for paediatric valve replacement (AVR). METHODS Prospective, multicentre follow-up of all patients receiving DAH AVR 8 European centres. RESULTS A total 143 implanted between February and 2023 137 children (106 male, 74%) with median age 10.8 years (interquartile range 6.6–14.6). Eighty-four (59%) had undergone previous cardiac operations 24 (17%) AVR. The diameter was 21 mm 19–23)....
Large-bore catheter aspiration embolectomy reduces thrombus burden and right ventricle strain improves haemodynamics after pulmonary embolism (PE). Sparse data are available for patients with high-risk PE contraindications to thrombolysis or failure, particularly if veno-arterial extracorporal membrane oxygenation (VA-ECMO) is required.All acute undergoing FlowTriever® percutaneous VA-ECMO circulatory support (or standby) at the University Hospital Zurich between April 2021 August 2022 were...
Abstract Background The reconstruction of heart valves provides substantial benefits, particularly in the pediatric population. We present our experience using decellularized extracellular matrix ( dECM , CorMatrix ® ) for aortic valve procedures. Methods retrospectively reviewed case histories 6 patients (aged from 2 months ‐ 14 years) who underwent surgery severe stenosis (n = 4) or regurgitation 2). Aortic repair was performed on all as a leaflet replacement extension. Follow‐ups were...
Options for paediatric aortic valve replacement (AVR) are limited if repair is not feasible. Results of Ross procedures inferior to adult results, and mechanical AVR imposes constant anticoagulation with the inherent risks.The study design was a prospective, multicentre follow-up all patients receiving decellularized homografts (DAHs) in 8 European centres.A total 106 children (77 boys) were operated (mean age 10.1 ± 4.8 years, DAH diameter 20.5 3.8 mm). A 60 (57%) had undergone previous...
The current standard for donor heart preservation consists of cold organ storage in three sequential plastic bags. This technique can cause freezing injuries the as temperature inside transport box is not monitored routinely. SherpaPak™ Cardiac Transport System (CTS) (Paragonix Technologies, Cambridge, MA, USA) aims to resolve this problem by maintaining a controlled between 4 and 8 °C. study reports first single-centre experience Switzerland with innovative single-use disposable...
Oral anticoagulation prior to emergency surgery is associated with an increased risk of perioperative bleeding, especially when this therapy cannot be discontinued or reversed in time. The goal study was analyse the impact different oral anticoagulants on outcome patients who underwent for acute type A aortic dissection (ATAAD).This a single-centre retrospective treated at time ATAAD. Outcomes new anticoagulant (NOAC) were compared respective outcomes Coumadin. Additionally, survival...
The pediatric population has benefited greatly by the evolution of ventricular assist devices (VADs) leading to miniaturization. Device design like HeartWare® VAD allows for implantation in smaller patients or even as an implantable biventricular device.A ten-year-old female patient (body surface area: 1.02 m2, 27 kg) waiting 7 months heart transplantation was admitted intensive care unit due terminal failure. Transthoracal echocardiography revealed failure with estimated ejection fraction...
Background: Cerebral embolic protection devices (CEPDs) have emerged as a mechanical barrier to prevent debris from reaching the cerebral vasculature, potentially reducing stroke incidence. Bovine aortic arch (BAA) is most common variant and represents challenge anatomy for CEPD insertion during transcatheter valve replacement (TAVR). Methods: Cohort study reporting SentinelTM Protection System insertion’s feasibility safety in 165 adult patients submitted transfemoral TAVR procedure April...
Aortic valve-sparing root replacement (AVSRR) is a technically demanding procedure. In experienced centers it offers excellent short- and long-term results, making the procedure an attractive alternative for aortic especially in young patients. The aim of this study was to analyze results AVSRR using David operation our institution over last 25 years.This single-center retrospective analysis outcomes operations performed teaching not running large AVSRR-program. Pre-, intra- postoperative...
Abstract For decades, bovine jugular vein conduits (BJV) and classic cryopreserved homografts have been the two most widely used options for pulmonary valve replacement (PVR) in congenital heart disease. More recently, decellularized (DPH) provided an alternative avenue PVR. Matched comparison of patients who received DPH PVR with considering patient age group, type defect, previous procedures. 319 were matched to BJV patients; mean was 15.3 (SD 9.5) years versus 19.1 (12.4) ( p = 0.001)....