A5103231723- Cardiovascular Disease and Adiposity
- Sirtuins and Resveratrol in Medicine
- Acute Kidney Injury Research
- Electrolyte and hormonal disorders
- Metabolomics and Mass Spectrometry Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Reproductive System and Pregnancy
- Receptor Mechanisms and Signaling
- Atherosclerosis and Cardiovascular Diseases
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Calcium signaling and nucleotide metabolism
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Tendon Structure and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Liver Disease and Transplantation
- Reproductive tract infections research
- Biochemical effects in animals
- Hormonal Regulation and Hypertension
- Renal function and acid-base balance
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Chronic Kidney Disease and Diabetes
University of Zurich
2019-2024
University of Hong Kong
2016-2019
Chinese University of Hong Kong
2016-2018
State Key Laboratory of Pharmaceutical Biotechnology
2017-2018
Pharmaceutical Biotechnology (Czechia)
2018
Mackay Memorial Hospital
2017
Mackay Medical College
2017
China Pharmaceutical University
2017
National Yang Ming Chiao Tung University
2013
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2013
Decreased glutamine concentrations are found during catabolic stress and related to susceptibility infections. However, little is known about the mechanism of modulation lymphocyte functions. Glutamine not only an important energy source in mitochondria, but also a precursor glutamate, which used for cellular glutathione (GSH) biosynthesis lymphocytes. In this study, we investigated effects on redox reaction proliferation. Peripheral blood mononuclear cells, obtained from healthy adult...
Extracorporeal shock-wave (ESW) treatment has been shown to be effective in promoting the healing of fractures. We aimed determine whether ESW could enhance growth bone-marrow osteoprogenitor cells. applied left femur rats 10 mm above knee at 0.16 mJ/mm2 a range between 250 and 2000 impulses. Bone-marrow cells were harvested after for one day subjected assessment colony-forming unit (CFU) granulocytes, monocytes, erythocytes, megakaryocytes (CFU-Mix), CFU-stromal (CFU-S) CFU-osteoprogenitors...
The hamster has been previously found to be a suitable model study the changes associated with diet-induced hyperlipidemia in humans. Traditionally, studies of utilize serum- or plasma-based biochemical assays and histopathological evaluation. However, unbiased metabonomic technologies have potential identify novel biomarkers disease. Thus, obtain better understanding progression discover biomarkers, we used proton nuclear magnetic resonance spectroscopy (1H-NMR)-based metabonomics approach...
Summary Background Measuring fractional exhaled nitric oxide (FeNO) is a simple and non‐invasive method for assessing airway inflammation. IL‐17 plays an important role in T cell‐dependent inflammatory response that occurs allergic asthma, it could act as potent activator of inducible synthase (iNOS) to amplify FeNO levels. Objectives To evaluate the differences CD4 + IL‐17A cell counts, serum levels, levels children with mild intermittent moderate severe persistent asthma classified by...
Nuclear receptors and their cofactors regulate key pathophysiological processes in atherosclerosis development. The transcriptional activity of these nuclear is controlled by the receptor corepressors (NCOR), scaffolding proteins that form basis large corepressor complexes. Studies with primary macrophages demonstrated deletion Ncor1 increases expression atherosclerotic molecules. However, role atherogenesis unknown.We generated myeloid cell-specific knockout mice crossbred them low-density...
Enhancing SIRT1 activity exerts beneficial cardiovascular effects. In diabetes, plasma levels are reduced. We aimed to investigate the therapeutic potential of chronic recombinant murine (rmSIRT1) supplementation alleviate endothelial and vascular dysfunction in diabetic mice (db/db).Left internal mammary arteries obtained from patients undergoing coronary artery bypass grafting with or without a diagnosis diabetes were assayed for protein levels. Twelve-week-old male db/db db/+ controls...
Background: Exercise has been shown to be beneficial in the treatment of type 2 diabetes mellitus (DM); its benefit immune function, however, remains determined. Objective: This study investigated effect a 12-week course Tai Chi Chuan (TCC) exercise on T cell helper (Th) reaction patients with DM. Methods: A case-control was performed 30 pairs DM and normal age-matched adults. Fasting blood glucose, HbA1c, mediators (interleukin (IL)-12, IL-4 transforming growth factor (TGF)β) transcription...
// Bo Bai 1,3,* , Andy W.C. Man 1,* Kangmin Yang 1 Yumeng Guo Cheng Xu Hung-Fat Tse 2 Weiping Han 3 Maria Bloksgaard 4 Jo G.R. De Mey Paul M. Vanhoutte Aimin 1,2 and Yu Wang State Key Laboratory of Pharmaceutical Biotechnology Department Pharmacology Pharmacy, The University Hong Kong, China Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology Research (A*STAR), Cardiovascular Renal Research, Institute Molecular Southern Denmark, Odense, Denmark * Co-first authors...
The lean diabetic patients with heart failure preserved ejection fraction (HFpEF) in Asia suffer from adverse clinical outcomes and poor life quality. suitable animal models are urgently needed for mechanistic study therapeutic innovations. Our reports that lipodystrophic mice seipin depletion lean, diabetic, recapitulate major manifestations of HFpEF, thereby clarifying diabetes per se may produce HFpEF characteristics. We further demonstrate increased cardiac titin phosphorylation reactive...
Introduction Dl-PHPB [potassium 2-(1-hydroxypentyl) benzoate] demonstrates robust neuroprotective effects in preclinical models of Alzheimer’s disease (AD), significantly ameliorating cognitive deficits and pathological hallmarks. However, the underlying mechanism remains largely unclear. The current study primarily focused on elucidating dl-PHPB’s mechanisms identifying potential targets AD models. Methods Comparative proteomic analyses were performed APP/PS1 mice orally administered either...
Extracorporeal shock-wave (ESW) treatment hasbeen shown to be effective in promoting the healing of fractures. We aimed determine whether ESW could enhance growth bone-marrow osteoprogenitor cells. applied left femur rats 10 mm above knee at 0.16 mJ/mm 2 a range between 250 and 2000 impulses. Bone-marrow cells were harvested after for one day subjected assessment colony-forming unit (CFU) granulocytes, monocytes, erythocytes, megakaryocytes (CFU-Mix), CFU-stromal (CFU-S) CFU-osteoprogenitors...
Neutrophils are the predominant inflammatory cells found in vaginal discharges of patients with Trichomonas vaginalis infection. We have investigated possible role interleukin-8 (IL-8) response elicited by T. This study has shown that induces blood monocytes to produce large amounts bioactive IL-8, mainly membrane components (MTV). Monocyte-derived IL-8 induced MTV was dose and time dependent. The peak level 102 +/- 11 ng/ml conditioned media (mean standard error; n = 5) obtained from...
Obesity and type 2 diabetes (T2D) are major risk factors for cardiovascular (CV) diseases. Dysregulated pro-apoptotic ceramide synthesis reduces β-cell insulin secretion, thereby promoting hyperglycaemic states that may manifest as T2D. Pro-apoptotic ceramides modulate sensitivity glucose tolerance while being linked to poor CV outcomes. Sirtuin-1 (SIRT1) is a NAD + -dependent deacetylase protects against pancreatic dysfunction; however, systemic levels decreased in obese-T2D mice promote...
Lipocalin-2 is not only a sensitive biomarker, but it also contributes to the pathogenesis of renal injuries. The present study demonstrates that adipose tissue–derived lipocalin-2 plays critical role in causing both chronic and acute Four-week treatment with aldosterone high salt after uninephrectomy (ANS) significantly increased circulating urinary lipocalin-2, induced glomerular tubular injuries kidneys WT mice. Despite expression lcn2 excretion mice selective deletion alleles tissue...
To study the mechanism of bacterial opsonization by immune globulin intravenous(IGIV) complement consumption and polymorphonuclear leukocyte (PMNL) membrane receptor (FcRlo, CR1, CR3)-mediated phagocytosis Staphylococcus epidermidis, Klebsiella pneumoniae, groups A B streptococci were examined. IGIV alone did not consume showed no opsonic activity itself for these organisms. When bacteria preopsonized in IGIV, significant amounts consumed (44%–94%) uptake killing occurred. The vitro...
Abstract Aims Lipocalin‐2 is a pro‐inflammatory molecule characterized by highly diversified pattern of expression and structure–functional relationships. In vivo , this exists as multiple variants due to post‐translational modifications and/or protein–protein interactions. modified polyamination, which enhances the clearance protein from circulation prevents its excessive accumulation in tissues. On other hand, animal studies suggest that non‐polyaminated lipocalin‐2 (npLcn2) plays causal...
We have investigated the mechanisms by which a murine IgA mAb directed against type III Ag (IgA anti-III mAb) of group B streptococci (GBS) protects neonatal rats from lethal infection with these organisms. Purified enhanced phagocytosis GBS rat peritoneal macrophages in vitro fourfold compared buffer-treated GBS. In absence antibody, serum did not promote phagocytosis, but addition to opsonized led sevenfold increase phagocytosis. Heat inactivation C destroyed ability enhance presence IgA....
Some guidelines or studies consider haematuria an indication for renal biopsy a potential cause of albuminuria that precludes accurate assessment urinary albumin excretion. This study examined the justification excluding in interpreting excretion patients with Type 2 diabetes and its associations other diabetes-related variables.Between May November 2008, at single centre data on urinalysis same urine sample were recruited. Urinary was determined by albumin/creatinine ratio spot urine....
Background The pericardial fluid may be representative of the interstitium heart. aim this study was to discriminate in cardiovascular disease patients between adipocytokines that are produced locally by heart and those supplied circulation. Methods Enzyme-linked immunosorbent assays (ELISA) were used determine levels N-terminal pro-brain natriuretic peptide (NT-pBNP), fatty acid-binding protein 4 (FABP4), leptin, lipocalin-2, neutrophil elastase, proteinase-3, high sensitivity C-reactive...
Exendin-4 is a strong therapeutic candidate for the treatment of metabolic syndrome. Related receptor agonist drugs have been on market since 2005. However, technical limitations and pain caused by subcutaneous injection severely limited patient compliance. The goal study to investigate biologically active exendin-4 analog could be administered orally. Using intraperitoneal glucose tolerance tests, we discovered that exendin4-cysteine oral gavage had distinct hypoglycemic effect in C57BL/6J...
The use of artificial or autologous materials for inferior vena cava (IVC) reconstruction is controversial. This study retrospectively explored the effects different on perioperative outcomes.This included 91 patients who underwent IVC during liver autotransplantation between 2014 and 2020. A univariate analysis was performed to select variables affecting postoperative morbidity. effect outcomes tested with a multivariable generalized linear model. morbidity operation time were further...