A5057947687- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Sleep and related disorders
- Sleep and Work-Related Fatigue
- Renin-Angiotensin System Studies
- Climate Change and Health Impacts
- Adipose Tissue and Metabolism
- Clusterin in disease pathology
- Advanced Glycation End Products research
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Biochemical Acid Research Studies
- Education and Work Dynamics
- Circadian rhythm and melatonin
- Genetic Associations and Epidemiology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neonatal Health and Biochemistry
- Acute Kidney Injury Research
- Adipokines, Inflammation, and Metabolic Diseases
- Sirtuins and Resveratrol in Medicine
- Biotin and Related Studies
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Birth, Development, and Health
- Electrolyte and hormonal disorders
Chinese University of Hong Kong
2010-2023
Hong Kong Jockey Club
2017-2018
University of Hong Kong
2014-2017
There is limited information on the relationship between risk of cardiovascular disease and joint effects sleep quality duration, especially from large, prospective, cohort studies. This study to prospectively investigate duration development coronary heart disease.This examined 60,586 adults aged 40 years or older. A self-administered questionnaire was used collect as well a wide range potential confounders. Events were self-reported in subsequent medical examinations. Two types Sleep Score...
Background: Chronic kidney disease (CKD) is a serious global public health challenge, but there limited information on the connection between air pollution and risk of CKD. Objective: The aim this study was to investigate association long-term exposure particulate matter (PM) with an aerodynamic diameter less than 2.5μm (PM2.5) development CKD in large cohort. Methods: A total 100,629 nonCKD Taiwanese residents age 20 y or above were included 2001 2014. Ambient PM2.5 concentration estimated...
The metabolic impact of inadequate sleep has not been determined in healthy individuals outside laboratories. This study aims to investigate the duration on five syndrome components a adult cohort.A total 162121 adults aged 20-80 years (men 47.4%) MJ Health Database, who were obese and free from major diseases, recruited followed up 1996 2014. Sleep insomnia symptoms assessed by self-administered questionnaire. Incident cases identified follow-up medical examinations. Cox proportional hazard...
Aims To evaluate the effects of habitual leisure-time physical activity (LTPA) on incident type 2 diabetes in a prospective cohort Chinese adults with impaired fasting glucose (IFG). Methods 44 828 aged 20–80 years newly detected IFG but free from cardiovascular and cerebrovascular disease were recruited followed up 1996 to 2014. Incident was identified by plasma ≥7 mmol/L. The participants classified into four categories based their self-reported weekly LTPA: inactive, low, moderate, or...
Lipocalin-2 is a proinflammatory adipokine upregulated in obese humans and animals. A pathogenic role of lipocalin-2 hypertension has been suggested. Mice lacking are protected from dietary obesity-induced cardiovascular dysfunctions. Administration causes abnormal vasodilator responses mice on high-fat diet (HFD).Wild-type knockout were fed with standard chow or HFD. Immunoassays performed for evaluating the circulating tissue contents lipocalin-2. The relaxation contraction arteries...
Objective The angiotensinogen gene has been linked with human essential hypertension in whites but the relationship Asian populations less consistent. This study aimed to examine genetic associations between and M235T, T174M, G-217A polymorphisms of Chinese siblings. Methods We studied members 126 families a hypertensive proband, including 434 siblings, which 178 were hypertensive. Parental history was recorded. examined using microarray method, validated by sequencing. transmission...
Adipose tissue is a pivotal organ determining longevity, due largely to its role in maintaining whole-body energy homeostasis and insulin sensitivity. SIRT1 NAD-dependent protein deacetylase possessing antiaging activities wide range of organisms. The current study demonstrates that mice with adipose tissue–selective overexpression hSIRT1(H363Y), dominant-negative mutant disrupts endogenous activity, show accelerated development metabolic aging. These mice, referred as Adipo-H363Y, exhibit...
Abstract Aims Lipocalin‐2 is a pro‐inflammatory molecule characterized by highly diversified pattern of expression and structure–functional relationships. In vivo , this exists as multiple variants due to post‐translational modifications and/or protein–protein interactions. modified polyamination, which enhances the clearance protein from circulation prevents its excessive accumulation in tissues. On other hand, animal studies suggest that non‐polyaminated lipocalin‐2 (npLcn2) plays causal...
“Compiler Principle†is an important branch of Computer Science in colleges and universities, which a combination theory practice. This paper analyzes the teaching status compiler principle, through understanding flipped class model, based on project driven to carry out research principle. Through practice, better mobilize enthusiasm students learning, effect has been significantly improved.