A5100395609- Cardiovascular Disease and Adiposity
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Congenital heart defects research
- Ion channel regulation and function
- Cardiovascular Health and Disease Prevention
- Cardiac electrophysiology and arrhythmias
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Physical Activity and Health
- Atherosclerosis and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Intensive Care Unit Cognitive Disorders
- Muscle Physiology and Disorders
- Nutritional Studies and Diet
- Nicotinic Acetylcholine Receptors Study
- Pulmonary Hypertension Research and Treatments
- Hippo pathway signaling and YAP/TAZ
Chongqing Medical University
2014-2024
Second Affiliated Hospital of Chongqing Medical University
2016-2024
Dalian Medical University
2016-2024
Mississippi State University
2023
Minhang District Central Hospital
2021
E Ink (South Korea)
2020
Second Affiliated Hospital of Guangzhou Medical University
2017
Guangzhou Medical University
2017
Qingdao University
2003-2016
Affiliated Hospital of Qingdao University
2015-2016
Inflammation and apoptosis play critical roles in the acute progression of ischemic injury pathology. Emerging evidence indicates that vagus nerve stimulation (VNS) following focal cerebral ischemia reperfusion (I/R) may be neuroprotective by limiting infarct size. However, underlying molecular mechanisms remain unclear. In this study, we investigated whether protective effects VNS I/R were associated with anti-inflammatory anti-apoptotic processes. Male Sprague-Dawley (SD) rats underwent at...
Abstract Background Albuminuria, the presence of excess protein in urine, is a well-known risk factor for early kidney damage among diabetic/prediabetic patients. There complex interaction between physical activity (PA) and albuminuria. However, relationship specific-domain PA albuminuria remained obscure. Methods Albuminuria was defined as urinary albumin/creatinine ratio (ACR) > 30 mg/g. self-reported by participants classified into transportation-related (TPA), occupation-related...
The epicardium is integral to cardiac development and facilitates endogenous heart regeneration repair. While miR-194-3p associated with cellular migration invasion, its impact on epicardial cells remains uncharted. In this work we use gain-of-function loss-of-function methodologies investigate the function of in development. We culture embryonic
Abstract Background Increased arterial stiffness is an important cause of cardiovascular disease (CVD). We examined determinants in subjects across strata glycaemic status. Methods A total 1249 from a sub‐study the Guangzhou Biobank Cohort Study (GBCS‐CVD) had brachial‐ankle pulse wave velocity (baPWV) measured by automatic oscillometric method. Major risk factors including glycosylated haemoglobin A1c (HbA 1c ), high sensitivity C‐reactive protein (hsCRP), fasting triglyceride, low‐ and...
Abstract IL-27 could inhibit the development of Th17 cells, and Th17/regulatory T-cell imbalance may reverse maternal tolerance in pre-eclampsia (PE). The aim this study was to investigate association between genetic polymorphisms IL27 with PE. Three SNPs (rs153109, rs17855750, rs181206) were genotyped a Chinese Han cohort 1040 PE patients 1247 normal pregnant women using TaqMan allelic discrimination real-time PCR method. CC genotypic distribution rs153109 significantly higher among cases...
Background: Valvular heart disease is obtaining growing attention in the cardiovascular field and it believed that calcific aortic valve (CAVD) most common valvular (VHD) world. CAVD does not have a fully effective treatment to delay its progression specific molecular mechanism of calcification remains unclear. Materials Methods: We obtained gene expression datasets GSE12644 GSE51472 from public comprehensive free database GEO. Then, series bioinformatics methods, such as GO KEGG analysis,...
In recent years, peri-organ fat has emerged as a diagnostic and therapeutic target in metabolic diseases, including diabetes mellitus. Here, we performed comprehensive analysis of epicardial adipose tissue (EAT) transcriptome expression differences between diabetic non-diabetic participants explored the possible mechanisms using various bioinformatic tools.RNA-seq datasets GSE108971 GSE179455 for EAT patients were obtained from public functional genomics database Gene Expression Omnibus...
Forkhead box protein P1 (FoxP1) is essential for cardiac development and the regulation of neovascularization, but its potential angiogenesis has not been explored. This study aims to investigate angiogenic role FoxP1 in a rat model myocardial infarction (MI). Adult male rats were subjected MI, Foxp1 was knocked down with lentivirus siRNA. Endothelial cell proliferation, angiogenesis, function also assessed. Cell scratch assay tubule formation analysis used detect migration ability tube...
To investigate the characteristics of patients with primary hypertension who had positive responses to cold pressor test (CPT).This cross-sectional study was conducted between November 2018 2019, and CPT performed in 48 hospitals. The demographic complications were collected through a questionnaire physical examinations. A 12-month follow-up identify occurrence following events: a) all-cause mortality; b) myocardial infarction; c) stroke; d) hospitalized for heart failure.The 30.7% patients....
A previous large-scale replication study validation of a genome wide association (GWAS) identified IκB kinase β (IKBKB) single nucleotide polymorphisms (SNPs) as risk factor associated with systemic lupus erythematosus (SLE) in Chinese Han population. IKBKB SNPs were polymerase (POLB) and reduced POLB expression, this was proposed to be an underlying cause human SLE development. In the current case-control study, we evaluated (rs12676482 rs2272733) (rs3136717 rs3136744) 946 patients 961...