A5100770516- Prostate Cancer Treatment and Research
- Polyomavirus and related diseases
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Renal and related cancers
- Renal cell carcinoma treatment
- Heat shock proteins research
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- RNA and protein synthesis mechanisms
- Cancer-related Molecular Pathways
- Antenna Design and Analysis
- Pharmacological Effects of Natural Compounds
- Mathematical and Theoretical Epidemiology and Ecology Models
- Traumatic Brain Injury and Neurovascular Disturbances
- Urological Disorders and Treatments
- Respiratory viral infections research
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Urinary and Genital Oncology Studies
- RNA Research and Splicing
Karolinska Institutet
2020-2025
Changchun University of Chinese Medicine
2024-2025
Ministry of Agriculture and Rural Affairs
2025
Jiangsu Academy of Agricultural Sciences
2025
Hubei University of Medicine
2020-2024
Shandong Academy of Sciences
2021-2024
Qilu University of Technology
2021-2024
Chengdu University of Traditional Chinese Medicine
2024
Chongqing Medical University
2006-2024
Second Affiliated Hospital of Chongqing Medical University
2006-2024
Colorectal cancer (CRC) is a major cause of death worldwide. Sensitive, non-invasive diagnostic screen methods are urgently needed to improve its survival rates. Stable circulating microRNA offers unique opportunities for the early diagnosis several diseases, including cancers. Our aim has been find new plasma miRNAs that can be used as biomarkers detection CRC.According results miRNA profiling performed on pooling samples form 10 CRC patients or healthy controls, panel (hsa-miR-10a, -19a,...
Rapid processing of tactile information is essential to human haptic exploration and dexterous object manipulation. Conventional electronic skins generate frames signals upon interaction with objects. Unfortunately, they are generally ill-suited for efficient coding temporal rapid feature extraction. In this work, we report a neuromorphic system that uses spike timing, especially the first-spike code dynamic about touch grasp. This strategy enables seamlessly highly millisecond resolution on...
MicroRNAs (miRNAs) are strongly implicated in cancer but their specific roles and functions the major cancers have yet to be fully elucidated. In this study, we defined oncogenic significance function of miR-95, which found elevated colorectal (CRC) tissues by microarray analysis. Evaluation an expanded CRC cohort revealed that miR-95 expression was up-regulated nearly half tumors examined (42/87) compared with corresponding noncancerous tissues. Ectopic overexpression human cell lines...
Abstract Multiple myeloma is the second most common hematological malignancy. Despite significant advances in treatment, relapse and carries a poor prognosis. Thus, it critical to elucidate genetic factors contributing disease progression drug resistance. Here, we carry out integrative clinical sequencing of 511 relapsed, refractory multiple (RRMM) patients define disease’s molecular alterations landscape. The NF-κB RAS/MAPK pathways are more commonly altered than previously reported, with...
Abstract INTRODUCTION Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) peptide plaques and intracellular neurofibrillary tangles formed hyperphosphorylated tau. Many attempts have been made to clarify the link between Aβ tau in pathogenesis, but conclusive data describing a pathway for this connection are still lacking. METHODS We developed neuronal model of Aβ‐induced toxicity studied downstream effects intraneuronal Aβ42 accumulation on hyperphosphorylation using confocal...
A series of imidazolepyridine derivatives were designed and synthesized according to the established docking studies. The imidazopyridine found have good potency physical-chemical properties. Several highly potent compounds such as 8ji, 8jl, 8jm identified with single nanomolar activities. most compound showed an IC50 3 nM, lower microsome clearance no CYP inhibition. profile appeared be superior BMS433771, supported further optimization.
MicroRNAs (miRNA) that are strongly implicated in carcinogenesis have recently reshaped our understanding of the role non-protein-coding RNAs. Here, we focused on function and molecular mechanism miR-202-3p its potential clinical application colorectal cancer.miR-202-3p expression was determined by quantitative reverse transcriptase PCR (qRT-PCR) 94 cancer tissues corresponding noncancerous (NCT). Cell proliferation colony formation assays vitro xenograft experiments vivo were used to...
The forkhead box M1 (FOXM1) transcription factor is one of the key genes inducing tumor invasion and metastasis by an unknown mechanism.In this study, we set out to investigate effects FOXM1 overexpression on metastatic human lung adenocarcinoma underlying mechanism.FOXM1 expression was analyzed in 78 frozen tissue samples using Affymetrix microarray a 155-paraffin-embedded with immunohistochemical detection.FOXM1 found be overexpressed adenocarcinoma, particularly patients, compared...
Ziresovir (RO-0529, AK0529) is reported here for the first time as a promising respiratory syncytial virus (RSV) fusion (F) protein inhibitor that currently in phase 2 clinical trials. This article describes process of RO-0529 potent, selective, and orally bioavailable RSV F highlights vitro vivo anti-RSV activities pharmacokinetics animal species. demonstrates single-digit nM EC50 potency against laboratory strains, well isolates cellular assays, more than one log viral load reduction...
Aims To understand more clearly the genetic ontogeny of inverted papilloma urinary bladder, we analysed telomerase reverse transcriptase ( TERT ) promoter mutation status in a group 26 papillomas comparison with urothelial carcinoma growth (26 cases), conventional (36 Ta non‐invasive carcinoma, 35 T2 invasive carcinoma) and cystitis glandularis (25 cases). Methods results mutations papilloma, growth, were found 15% (four 26), 58% (15 63% (45 71) 0% (none 25), respectively. C228T predominant...
Advanced prostate cancer initially responds to androgen deprivation therapy (ADT), but the disease inevitably recurs as castration-resistant (CRPC). Although CRPC abiraterone and enzalutamide, invariably becomes nonresponsive these agents. Novel approaches are required circumvent resistance pathways extend survival, mechanisms underlying remain poorly defined. Our group previously showed histone lysine-N-methyltransferase EZH2 be overexpressed in quantitatively associated with progression...