A5101763552- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Pregnancy and preeclampsia studies
- Medical Research and Treatments
- Traditional Chinese Medicine Studies
- Autophagy in Disease and Therapy
- Tendon Structure and Treatment
- Bone Metabolism and Diseases
- Traditional Chinese Medicine Analysis
- Musculoskeletal pain and rehabilitation
- Dermatologic Treatments and Research
- Ubiquitin and proteasome pathways
- Reproductive System and Pregnancy
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Disease and Adiposity
- Sarcoidosis and Beryllium Toxicity Research
- Extracellular vesicles in disease
- Venous Thromboembolism Diagnosis and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Healthcare and Venom Research
- Lipid metabolism and disorders
- MicroRNA in disease regulation
- Periodontal Regeneration and Treatments
- Pediatric health and respiratory diseases
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2023
First People's Hospital of Chongqing
2023
Åbo Akademi University
2023
Sichuan Agricultural University
2022
Nanjing Medical University
2013-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Michigan Center for Translational Pathology
2011-2021
University of Michigan–Ann Arbor
2011-2021
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2020
Chongqing Medical University
2016-2020
Abstract Objective To analyze the CARD15 gene in families with heritable multi‐organ granulomatoses, including original Blau syndrome kindred as well other related granulomatous conditions. Methods Linkage mapping was performed 10 families. Observed recombination events were used to exclude regions centromeric or telomeric 16q12.1, and critical region refined <3 cM, corresponding a physical distance of 3.5 megabasepairs. Based on its known biochemical function, analyzed positional...
Low-intensity pulsed ultrasound (LIPUS) is a mechanical stimulus that plays key role in regulating the differentiation of bone marrow mesenchymal stem cells (BMSCs). However, way which it affects chondrogenic BMSCs remains unknown. In this study, we aimed to investigate whether LIPUS able influence TGF-β1-induced chondrogenesis through integrin-mechanistic target Rapamycin (mTOR) signaling pathway.BMSCs were isolated from rat and cultured either standard or TGF-β1-treated culture medium....
Low-intensity pulsed ultrasound (LIPUS) can induce mesenchymal stem cell (MSC) differentiation, although the mechanism of its potential effects on chondrogenic differentiation is unknown. Since autophagy known to regulate MSCs, aim our study was determine whether LIPUS induced chondrogenesis via regulation. MSCs were isolated from rat bone marrow, cultured in either standard or medium, and stimulated with 3 MHz given 20% on–off cycles, without prior addition an inhibitor agonist....
Objective The present study explored whether low-intensity pulsed ultrasound (LIPUS) enhances the therapeutic efficacy of mesenchymal stem cells (MSCs) in osteoarthritis (OA) cartilage repair by regulating autophagy-mediated exosome release. Design MSCs were isolated from rat bone marrow and treated with rapamycin, 3-methyladenine, or LIPUS. mechanism LIPUS-stimulated release was analyzed inhibiting autophagy. In addition, co-cultured OA chondrocytes stimulated LIPUS, without inhibitor...
Knee osteoarthritis (KOA) is the leading cause of pain and stiffness, affecting older adults' physical function quality life. As a form mind-body exercise, Tai Chi has been recommended as an exercise prescription for KOA patients. This study examined effects continuation modified exercises on life in elderly women with KOA.We conducted single-blind, randomized controlled trial (RCT) 40 KOA. The participants were to 12 weeks or control group. group attended kind training sessions three times...
Mesenchymal stem cell (MSC) migration is promoted by low-intensity pulsed ultrasound (LIPUS), but its mechanism unclear. Since autophagy known to regulate migration, our study aimed investigate if LIPUS promotes the of MSCs via regulation. We also effects intra-articular injection following stimulation on osteoarthritis (OA) cartilage. For in vitro study, rat bone marrow-derived were treated with an inhibitor or agonist, and then they stimulated LIPUS. Migration was detected transwell...
Coronavirus disease 2019 (COVID-19), a severely spreading pandemic, has dramatically brought physiological and economical burdens to people.Although the injectable vaccines have some achievements for coronavirus defense, they still generate accompanied pain, untoward reaction cannot take part in mucosal immunity.Inhalable vaccines, as safe, facile efficient strategy, been presented protect body from virus by inducing robust immunity.Here, we give perspective of an inhalable COVID-19 vaccine...
Diabetic osteoporosis represents a serious health condition with increasing incidence. Previous studies have shown that microRNA (miR)-335-5p is highly expressed in MC3T3-E1 osteoblasts and promotes their differentiation via downregulating the expression of dickkopf‑1 (DKK1). The present study investigated effects miR‑335‑5p on apoptosis induced by high glucose (HG), as well underlying molecular mechanisms. MC3T3‑E1 were transfected mimics or control miR cultured under HG conditions for...
Objective . Abnormal expression of ABCA1 and ABCG1 in the placenta can elicit lipid metabolism disorder adverse pregnancy outcomes. However, whether it is associated with preterm delivery remains unclear. Our present study aimed to evaluate relationship between abnormal or delivery. Methods Maternal blood placental tissues from women spontaneous deliveries (SPD), iatrogenic (IPD), term (TD) were collected. The content subsequently measured. Results Compared IPD TD groups, HDL, TD, LDL, TC...
We conducted this study to evaluate the effect of rTMS combined with rPMS on stroke patients arm paralysis after CSCNTS.A case-series four paralysis, ages ranging from 39 51 years, that underwent CSCNTS was conducted. Patients were treated 10 HZ contralesional primary motor cortex 20 groups elbow and wrist muscles for 15 days.The muscle tone flexor (EFM), extensor (EEM), (WFM) digitorum (FD) reduced immediately operation followed by increasing gradually. After rehabilitation, EEM EFM 14%...
To elucidate whether cranial electrotherapy stimulation (CES) improves depression-like behavior of post-stroke depression (PSD) via regulation glutathione peroxidase 4 (GPX4)-mediated brain-derived neurotrophic factor (BDNF) expression. Middle cerebral artery occlusion (MCAO) and chronic unpredictable mild stress (CUMS) were used to develop a rat PSD model. CES was applied, RAS-selective lethal 3 (RSL3) injected into the hippocampus inhibit GPX4 in rats. The detected by sucrose preference...
Diabetes and osteoporosis are common metabolic diseases. Abnormal high glucose can lead to the apoptosis of osteoblasts. Autophagy is a highly conserved cellular process that degrades proteins or organelles. In present study, we comparatively analyzed effects fluctuation on autophagy MC3T3-E1 osteoblasts.MC3T3-E1 cells were respectively treated with different concentrations D-glucose: 5.5 mM for control group, 25 group 5.5/25 group.High decreased proliferation activated autophagy. Also,...
To evaluate the effect of ultrasound-targeted simvastatin-loaded microbubble destruction (UTMD SV ) for alleviation progression osteoarthritis (OA) in rabbits through modulation peroxisome proliferator-activated receptor (PPARγ).In vitro, OA chondrocytes were treated with ultrasound (US), US-targeted (UTMD), simvastatin (SV), and UTMD on alternate days four weeks. Chondrocytes also PPARγ inhibitor, inhibitor+ , . The cholesterol efflux rate triglyceride levels measured using an assay kit oil...
Manganese (Mn) is now known to have a variety of toxicities, particularly when exposed it in the workplace. However, there are still ineffective methods for reducing Mn's hazardous effects. In this study, new selenium polysaccharide (Se-PCS) was developed from shell Camellia oleifera reduce Mn toxicity vitro and vivo. The results revealed that Se-PCS may boost cell survival Hep G2 cells activate antioxidant enzyme activity, lowering ROS apoptosis. Furthermore, after being treated with...