A5102798143- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- HIV-related health complications and treatments
- Knee injuries and reconstruction techniques
- Protease and Inhibitor Mechanisms
- Cardiovascular Disease and Adiposity
- Nuclear Structure and Function
- Pain Mechanisms and Treatments
- Laser Applications in Dentistry and Medicine
- Metabolism and Genetic Disorders
- Therapeutic Uses of Natural Elements
- Periodontal Regeneration and Treatments
- Pelvic and Acetabular Injuries
- Mechanical Circulatory Support Devices
- Trigeminal Neuralgia and Treatments
- Urinary Tract Infections Management
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Cardiac Ischemia and Reperfusion
- Diabetic Foot Ulcer Assessment and Management
- Spondyloarthritis Studies and Treatments
- Hernia repair and management
- Neonatal and fetal brain pathology
Nanjing Medical University
2011-2025
Jiangsu Province Hospital
2024
Baoji City Central Hospital
2021
Fujian University of Traditional Chinese Medicine
2020
Guangzhou Medical University
2020
Affiliated Hospital of Qingdao University
2019
Jinan University
2016
Low-intensity pulsed ultrasound (LIPUS) is a mechanical stimulus that plays key role in regulating the differentiation of bone marrow mesenchymal stem cells (BMSCs). However, way which it affects chondrogenic BMSCs remains unknown. In this study, we aimed to investigate whether LIPUS able influence TGF-β1-induced chondrogenesis through integrin-mechanistic target Rapamycin (mTOR) signaling pathway.BMSCs were isolated from rat and cultured either standard or TGF-β1-treated culture medium....
Low-intensity pulsed ultrasound (LIPUS) can induce mesenchymal stem cell (MSC) differentiation, although the mechanism of its potential effects on chondrogenic differentiation is unknown. Since autophagy known to regulate MSCs, aim our study was determine whether LIPUS induced chondrogenesis via regulation. MSCs were isolated from rat bone marrow, cultured in either standard or medium, and stimulated with 3 MHz given 20% on–off cycles, without prior addition an inhibitor agonist....
Objective The present study explored whether low-intensity pulsed ultrasound (LIPUS) enhances the therapeutic efficacy of mesenchymal stem cells (MSCs) in osteoarthritis (OA) cartilage repair by regulating autophagy-mediated exosome release. Design MSCs were isolated from rat bone marrow and treated with rapamycin, 3-methyladenine, or LIPUS. mechanism LIPUS-stimulated release was analyzed inhibiting autophagy. In addition, co-cultured OA chondrocytes stimulated LIPUS, without inhibitor...
Mesenchymal stem cell (MSC) migration is promoted by low-intensity pulsed ultrasound (LIPUS), but its mechanism unclear. Since autophagy known to regulate migration, our study aimed investigate if LIPUS promotes the of MSCs via regulation. We also effects intra-articular injection following stimulation on osteoarthritis (OA) cartilage. For in vitro study, rat bone marrow-derived were treated with an inhibitor or agonist, and then they stimulated LIPUS. Migration was detected transwell...
Objectives To investigate whether low‐intensity pulsed ultrasound (US) has different protective effects on early and late rabbit osteoarthritis cartilage via the integrin/focal adhesion kinase (FAK)/mitogen‐activated protein (MAPK) signaling pathway. Methods Thirty‐six New Zealand White rabbits were divided into control, osteoarthritis, treatment, treatment groups. The groups underwent anterior cruciate ligament transection. remaining sham operations with knee joint exposure. exposed to US 4...
To evaluate the effect of ultrasound-targeted simvastatin-loaded microbubble destruction (UTMD SV ) for alleviation progression osteoarthritis (OA) in rabbits through modulation peroxisome proliferator-activated receptor (PPARγ).In vitro, OA chondrocytes were treated with ultrasound (US), US-targeted (UTMD), simvastatin (SV), and UTMD on alternate days four weeks. Chondrocytes also PPARγ inhibitor, inhibitor+ , . The cholesterol efflux rate triglyceride levels measured using an assay kit oil...
Abstract Background This study aimed to develop and validate an individualized nomogram predict the risk of positive hidden blood loss (HBL) in patients with single-level thoracolumbar burst fracture (TBF) during perioperative period. Methods We conducted a retrospective investigation including 150 consecutive TBL, corresponding patient data was extracted from March 2013 2019. The independent factors for HBL were screened using univariate multivariate logistic regression analyses. According...
High-intensity interval training (HIIT) is a physical therapy that may benefit patients with osteoarthritis (OA). Cacna2d1 calcium channel subunit protein plays an important role in the activity of nerve cells. However, there currently no evidence on HIIT relieving OA-associate hyperalgesia by decreased Cacna2d1. Our study established OA rat models intra-articular injection monosodium iodoacetate (MIA). This experiment was divided into two stages. The first stage comprised three groups:...
An animal model of Osteoarthritis (OA) was established to observe the influences low-intensity pulsed ultrasound (LIPUS) and nano magnet application (NMA) on Collagenase 3 (MMP-13) expression activation status mitogen activated protein kinases (MAPKs) in rabbit. 24 experimental rabbits from New Zealand were randomly divided into four groups: LIPUS, NMA, LIPUS + NMA group, control group. The rabbit OA right knee joint received ACLT operation. Rabbits group treatment given treatment. In both...
Stress urinary incontinence (SUI) is common, impacts women's quality of life and generates high costs. Physiotherapy the first line therapy if it fails, suburethral slings are currently gold standard in SUI surgery. Bulking agents injected periurethrally might be a beneficial alternative, but there paucity data on bulking therapy. Aim current-study was to analyze efficacy safety setting tertiary referral center prospectively.In last 13 years 514 elderly women with were treated by injection...
Abstract Background Thrombolytic therapy is one of the most effective treatments to achieve rapid thrombus clearance and recanalization blocked vessels in thrombotic diseases. However, application thrombolytic strategy has been limited due unsatisfied efficacy, relatively higher bleeding complications, consequently restricted indications.[1] With development nanotechnology biotechnology, platelet membrane nanoparticles have developed enable targeted delivery agents local sites.[2]...
Ultrasound is commonly used to treat knee osteoarthritis (KOA), which has unique advantages with regard relieving pain and inflammation as well delaying cartilage degeneration, but the underlying mechanisms are less clear. The study aimed investigate therapeutic effects of ultrasound on vascular endothelial growth factor (VEGF) expression in cartilage, synovium, synovial fluid (SF) a rabbit model KOA. Twenty-four New Zealand rabbits were randomly divided into (group A), sham B) no-ACLT...
To study the changes of body composition in females patients with human immunodeficiency virus (HIV)-related lipodystrophy (LD) syndrome (HIV-LD).Totally 25 female who were treated our hospital from January 2002 to December 2009 divided into LD group and non-LD based on existence LD. All these receiving highly active antiretroviral therapy (HAART). In addition, 12 healthy women set as controls. Total regional measured by dual X-ray absorptiometry all three groups.The fat mass (FM) was...
Abstract Background: The present study explored whether low-intensity pulsed ultrasound (LIPUS) enhances the therapeutic efficacy of mesenchymal stem cells (MSCs) in osteoarthritis (OA) cartilage repair by regulating autophagy-mediated exosome release. Methods: MSCs were isolated from rat bone marrow and treated with rapamycin, 3-methyladenine, or LIPUS. mechanism LIPUS-stimulated release was analyzed inhibiting autophagy. Additionally, co-cultured OA chondrocytes stimulated LIPUS, without...
Objective To observe the effect of low-intensity pulsed ultrasound (LIPUS) on angiogenesis and vascular invasion in osteochondral junctions rabbits with osteoarthritis. Methods Eighteen 2 to 2.5 kg New Zealand were randomly divided into an early control group (EC), osteoarthritis (EO) plus LIPUS treatment (ET), each 6. The EO ET groups received anterior cruciate ligament resection at their left hind limbs, while those EC sham-operated. was exposed radiation four weeks later when had...
Objective To observe any effect of low intensity pulsed ultrasound (LIPUS) on the expression integrin-focal adhesion kinase (FAK)-mitogen-activated protein (MAPK) mechanochemical transduction pathway-related proteins in chondrocytes rabbits with knee osteoarthritis (OA).Methods Of 18 New Zealand white selected for study,twelve received anterior cruciate ligament transection to model OA.The remaining 6 served as normal controls.At 4th week after modeling were sacrificed and isolated cultured...