A5031415929- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Microbial Natural Products and Biosynthesis
- Phytochemistry and Biological Activities
- Fern and Epiphyte Biology
- Pharmacological Effects of Natural Compounds
- Alkaloids: synthesis and pharmacology
- Tryptophan and brain disorders
- Metabolomics and Mass Spectrometry Studies
- Fungal Biology and Applications
- Phytochemical compounds biological activities
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Analysis
- Alzheimer's disease research and treatments
- Medicinal Plants and Neuroprotection
- Diet, Metabolism, and Disease
- Stress Responses and Cortisol
- Berberine and alkaloids research
- Neurological Disease Mechanisms and Treatments
- Phytochemicals and Antioxidant Activities
- Microbial Metabolism and Applications
- TGF-β signaling in diseases
- Ziziphus Jujuba Studies and Applications
- Nuts composition and effects
- Birth, Development, and Health
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2016-2025
Hunan University
2024-2025
Minzu University of China
2024
Hunan University of Traditional Chinese Medicine
2023-2024
Xiangya Hospital Central South University
2021
Central South University
2011-2021
To investigate antidepressant active ingredients of XYP (Xiaoyao Pill), while predicting its primary pharmacodynamic material basis and underlying mechanisms action. UPLC-Q-TOF-MS/MS was used to identify the XYP. In addition, based on analysis components, network pharmacology molecular docking were potential therapeutic targets possible signaling pathways in treatment depression. A total 102 chemical 10 prototype components 16 metabolites absorbed brain identified Network showed that these...
Background and Objectives: To explore the mechanism of action differential components medicinal edible lilies in treating depression by network pharmacology using UPLC-Q-TOF-MS technology. Methods: The chemical composition was analyzed, screening for unique compounds. Searched depression-related targets. Constructed PPI networks. Performed GO KEGG analyses. Built a components, conducted molecular docking. In addition, contents regaloside before after lily processing were compared Results:...
A serum medicinal chemistry analysis was performed to investigate the pharmacological basis of Xintongtai granule and predict potential mechanism anti-atherosclerotic action based on blood components.
In the process of discovering more neural-system-related bioactive compounds from Xylaria nigripes, xylariamino acid A (1), a new amino derivative, and isovaleric phenethyl ester (2) were isolated identified. Their structures absolute configurations determined by analyses IR, HRESIMS, NMR spectroscopic data, gauge-independent atomic orbital (GIAO) calculation, as well electronic circular dichroism (ECD) calculation. The evaluated for their neuroprotective effects against damage to PC12 cells...
Palhinosides A–H (1–8), new flavone glucosidic truxinate esters, including β-truxinate and μ-truxinate forms, were isolated from Palhinhaea cernua. Their structures elucidated by extensive spectroscopic methods chemical analyses. The glucoside cyclodimers possess a unique cyclobutane ring in their carbon scaffolds. Compounds 2–7 represent three pairs of stereoisomers (2/3, 4/5, 6/7). protective effects 1–8 against the damage HT-22 cells induced l-glutamate evaluated, compounds 4 5 showed...
Aging is an important cause of cognitive dysfunction. Liuwei Dihuang decoction (LW), a commonly applied Chinese medicine formula, widely used for the treatment aging-related diseases in China. Previously, LW was confirmed to be effective prolonging life span and reducing oxidative stress aged mice. Unfortunately, underlying mechanism remains unclear. The aim this study interpret by which alleviates dysfunction related aging from perspective microbiota-gut-brain axis.All C57BL/6 mice (n = 60)...
A new selaginellin derivative, M (1), together with one known compound, E (2), was isolated from Selaginella pulvinata. The structure of the compound elucidated and named as (R,S)-4-((4′-hydroxy-4-((2-hydroxyethoxy)methyl))-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene)cyclohexa-2,5-dienone on basis spectroscopic data including UV, IR, 1D, 2D NMR well HR-ESI-MS analysis.
A new flavonoid, 6-(5-acetyl-2-methoxyphenyl)-apigenin (1), together with nine known compounds (2–10), was isolated from Selaginella uncinata (Desv.) Spring. This is the first report of spectroscopic data compound 3. Compound 2 reported this species. The structure elucidated on basis evidence, including 1D and 2D NMR as well HR-EI-MS analysis.