A5030409934- Heavy Metal Exposure and Toxicity
- Autophagy in Disease and Therapy
- Trace Elements in Health
- Mycotoxins in Agriculture and Food
- Bone Metabolism and Diseases
- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Microtubule and mitosis dynamics
- Microplastics and Plastic Pollution
- Nanoparticles: synthesis and applications
- Fern and Epiphyte Biology
- Connexins and lens biology
- Bone health and treatments
- Ion channel regulation and function
- MicroRNA in disease regulation
- Nitric Oxide and Endothelin Effects
- Heme Oxygenase-1 and Carbon Monoxide
- Graphene and Nanomaterials Applications
- Cell death mechanisms and regulation
- Sperm and Testicular Function
- Selenium in Biological Systems
- Mesenchymal stem cell research
- Biochemical Acid Research Studies
- Nuts composition and effects
- Cannabis and Cannabinoid Research
Yangzhou University
2016-2025
Hunan Normal University
2020-2025
Hunan Provincial People's Hospital
2025
Jiangsu Provincial Center for Disease Control and Prevention
2016-2024
Northern Jiangsu People's Hospital
2016-2024
Shanghai Electric (China)
2024
Ministry of Education of the People's Republic of China
2019-2023
Hainan Medical University
2021-2023
Central South University
2009-2021
China Pharmaceutical University
2018-2020
A vertebrate securin (vSecurin) was identified on the basis of its biochemical analogy to Pds1p protein budding yeast and Cut2p fission yeast. The vSecurin bound a homolog separins Esp1p Cut1p degraded by proteolysis mediated an anaphase-promoting complex in manner dependent destruction motif. Furthermore, expression stable Xenopus mutant blocked sister-chromatid separation but did not block embryonic cell cycle. proteins share extensive sequence similarity with each other show no either...
The Holliday junction recombination intermediate, an X-shaped DNA molecule (xDNA), was analyzed at rDNA in mitotically growing yeast. In wild-type cells, xDNA is only detected S phase, suggesting that stimulated to repair replication- related lesions. A search for mutations increase the level of uncovered a gene encoding subunit polymerase α. Systematic examination replication mutants revealed defects α and δ but not ε complex stimulate xDNA. These xDNAs are junctions intermediates. greatly...
Genetic studies in yeast and Drosophila have uncovered a conserved acetyltransferase involved sister-chromatid cohesion. Here, we described the two human orthologues, previously named EFO1/ESCO1 EFO2/ESCO2. Similar to their (Eco1/Ctf7 Eso1) fly (deco) counterparts, both proteins feature C-terminal domain consisting of H2C2 zinc finger motif an that is able catalyze autoacetylation reaction vitro. However, no similarity can be detected outside domain. RNA interference depletion experiment...
Zearalenone (ZEA) can perturb the differentiation of cells, reduce generation reproductive cells and induce a death germ but molecular mechanism remains unclear. In order to investigate potential ZEA-induced cell cycle arrest apoptosis, we studied effects ZEA on proliferation, cell-cycle distribution, cell-cycle-related proteins, death, ROS ATP/AMPK pathway in Sertoli cells. The role ROS, ER stress apoptosis was explored by using antioxidant NAC, inhibitor 4-PBA AMPK dorsomorphin,...
Cadmium (Cd) is a toxic metal capable of damaging brain. Studies have demonstrated that Cd can induce apoptosis in neuronal cells. The CD95/APO-1 (Fas)/Fas Ligand (FasL) signaling pathway one the primary pathways, but role and regulatory mechanism this cells remain unclear. Here, we underlying Fas/FasL system involving mitochondrial apoptotic Primary rat cerebral cortical neurons PC12 were exposed to Cd, which significantly activated expression Fas, FasL, Fas-associated death domain (FADD)...
Cadmium (Cd) is a potential pathogenic factor in the urinary system that associated with various kidney diseases. Microplastics (MPs), comprising of plastic particles less than 5 mm diameter, are major carrier contaminants. We applied 10 mg/L particle μm MPs and 50 CdCl2 water for three months vivo assay to assess damaging effects Cd exposure on kidney. In tests showed exacerbated Cd-induced injury. addition, involvement oxidative stress, autophagy, apoptosis, fibrosis mouse kidneys were...
Microplastics have become a new type of environmental pollutant that can accumulate in various tissues and organs the body cause chronic damage. In this study, two different size polystyrene microplastics (PS-MPs, 5 μm 0.5 μm) exposure models were established mice to investigate effects PS-MPs with particle sizes on oxidative stress liver. The results showed caused decrease weight liver-to-body weight. hematoxylin eosin staining transmission electron microscopy led disorganized cellular...
Cadmium (Cd) is an important environmental pollutant that causes liver damage and induces nonalcoholic fatty disease (NAFLD). NAFLD a fat accumulation has significant effects on the body. Melatonin (Mel) endogenous protective molecule with antioxidant, anti-inflammatory, antiobesity, antiaging effects. However, whether Mel can alleviate Cd-induced its mechanism remains unclear. First, in vivo, we found maintained mitochondrial structure function, inhibited oxidative stress, reduced injury....
Cadmium (Cd) is a common environmental pollutant and occupational toxicant that seriously affects various mammalian organs, especially the kidney. Iron ion an essential trace element in body, disorder of iron metabolism involved development multiple pathological processes. An overload can induce new type cell death, defined as ferroptosis. However, whether abnormal Cd-induced nephrotoxicity role ferroptosis need to be further elucidated. Sprague Dawley male rats were randomly assigned into...
Chickens are a major source of meat and eggs in human food have significant economic value. Cadmium (Cd) is common environmental pollutant that can contaminate feed drinking water, leading to kidney injury livestock poultry, primarily by inducing the generation free radicals. It necessary develop potential medicines prevent treat Cd-induced nephrotoxicity poultry. Luteolin (Lut) natural flavonoid compound mainly extracted from peanut shells has variety biological functions defend against...
A recently discovered environmental contaminant, microplastics (MPs) are capable of amassing within the body and pose a grave threat to health both humans animals. It is widely acknowledged that combination cadmium (Cd), hazardous heavy metal, produces synergistic deleterious effects. Nevertheless, mechanism by which co-exposure polyvinyl chloride (PVC-MPs) Cd damages liver avian females unknown. Globally prevalent subject extensive research in mammals, non-alcoholic fatty disease (NAFLD)...
Cadmium (Cd) and polystyrene microplastics (PS-MPs), two ubiquitous environmental contaminants, produce unique synergistic toxicity when co-existing. Key unanswered questions include specific effects on liver function potential mechanisms. In this study, C57BL/6 mice AML12 cells were used to establish in vivo vitro models elucidate the of combined exposure PS-MPs Cd their The results showed that caused significantly more damage than alone. As observed by transmission electron microscopy...