A5100713939- Escherichia coli research studies
- Bacterial Genetics and Biotechnology
- Gut microbiota and health
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Cancer-related molecular mechanisms research
- Antibiotic Resistance in Bacteria
- Clostridium difficile and Clostridium perfringens research
- Bacteriophages and microbial interactions
- Vibrio bacteria research studies
- Antimicrobial Peptides and Activities
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Probiotics and Fermented Foods
- Selenium in Biological Systems
- Bacterial biofilms and quorum sensing
- RNA Interference and Gene Delivery
- Mycotoxins in Agriculture and Food
- Mycobacterium research and diagnosis
- Molecular Biology Techniques and Applications
Guangzhou University of Chinese Medicine
2025
Chinese Academy of Agricultural Sciences
2025
Yangzhou University
2015-2024
Sichuan University
2016-2024
Ministry of Education of the People's Republic of China
2014-2024
University of South China
2021-2024
Shandong Province Animal Husbandry and Veterinary Bureau
2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2023
University of Electronic Science and Technology of China
2023
Burning Rock Biotech (China)
2023
Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals humans; however, it remains know whether melatonin prevents obesity through microbiota. Here, we found that high-fat diet promoted the accumulation intestinal dysbiosis mice, while oral supplementation alleviated reversed dysbiosis, including diversity of microbiota, relative abundances Bacteroides Alistipes, functional profiling microbial communities, such as energy metabolism, carbohydrate...
Abstract Melatonin influences intestinal microbiota and the pathogenesis of various diseases. This study was conducted to explore whether melatonin alleviates weanling stress through in a mouse model. supplementation mice (provided drinking water at dosage 0.2 mg/mL for 2 weeks) significantly improved body weight gain (1.4 ± 0.03 g/day group vs 1.2 0.06 control group) morphology (ie, villus length, crypt depth, ratio), but had little effect on proliferation or apoptosis cells, numbers Paneth...
Zearalenone (ZEA) can perturb the differentiation of cells, reduce generation reproductive cells and induce a death germ but molecular mechanism remains unclear. In order to investigate potential ZEA-induced cell cycle arrest apoptosis, we studied effects ZEA on proliferation, cell-cycle distribution, cell-cycle-related proteins, death, ROS ATP/AMPK pathway in Sertoli cells. The role ROS, ER stress apoptosis was explored by using antioxidant NAC, inhibitor 4-PBA AMPK dorsomorphin,...
The aim of this study was to investigate the molecular mechanisms destruction cytoskeletal structure by Zearalenone (ZEA) in mouse-derived TM4 cells. In order role autophagy, oxidative stress and endoplasmic reticulum(ER) process structure, effects ZEA on cell viability, stress, ER MAPK PI3K- AKT- mTOR signaling pathways were studied. data demonstrated that damaged through induction autophagy leads alteration via elevated stress. Our results further showed stimulated PI3K-AKT-mTOR addition,...
The type III secretion system (T3SS) is an important genetic determinant that mediates interactions between Gram-negative bacteria and their eukaryotic hosts. Our understanding of the T3SS continues to expand, yet availability new bacterial genomes prompts questions about its diversity, distribution evolution. Through a comprehensive survey ∼20 000 genomes, we identified 174 non-redundant T3SSs from 109 genera 5 phyla. Many are environmental strains have not been reported interact with...
Abstract Granulosa cells play important roles in ovarian follicular development. To better understand the molecular mechanisms involved this physiological process chicken, high-throughput transcriptome analyses were performed to study expression profiles of granulosa harvested from 6 mm white follicles, F5 follicles and F1 follicles. The elucidated a clear tendency shifting its profile proliferation differentiation during Transcripts down-regulated mainly associated with cell division, cycle...
Abstract Staphylococcus aureus is a pathogen that the causative agent of several human and veterinary infections plays critical role in clinical subclinical mastitis cattle. Autophagy conserved defence mechanism eukaryotes. Studies have reported S can subvert autophagy survive cells. survival cells an important cause chronic persistent infection. However, it unclear whether escape innate immune In this study, initiation due to presence was detected bovine macrophages. We observed autophagic...
Staphylococcus pseudintermedius (S. pseudintermedius) is a common pathogen that causes canine corneal ulcers. However, the pathogenesis remained unclear. In this study, it has been demonstrated S. invaded epithelial cells (CCECs) intracellularly, mediating oxidative damage and pyroptosis by promoting accumulation of intracellular reactive oxygen species (ROS) activating NLRP3 inflammasome. The stroma was infected with to establish ulcer model in vivo. infectious CCECs established vitro...
Intestinal stem cells can be differentiated into absorptive enterocytes and secretory cells, including Paneth goblet enteroendocrine cells. Glutamine is a primary metabolic fuel of small intestinal essential for the viability growth cells.Whether glutamine supplementation affects differentiation unknown.Three-week-old ICR (Institute Cancer Research) male mice were divided randomly two groups: 1) receiving basal diet normal drinking water 2) supplemented with glutamine. After 2 weeks,...
To determine the role of autophagy in innate immune response to fungal keratitis (FK) caused by Aspergillus fumigatus infection.Corneal samples obtained from patients and mice with FK were visualized via transmission electron microscopy (TEM). Autophagy-related proteins LC3B-II, Beclin-1, LAMP-1, p62 A. fumigatus-infected corneas C57BL/6 tested Western blot. After treatment inhibitors 3-methyladenine (3-MA), chloroquine (CQ), or inducer rapamycin, autophagy-related detected Corneas...
Bovine mastitis is a prevalent disease that causes serious economic problems globally in the dairy industry. Staphylococcus aureus an important pathogen of bovine mastitis. This study was conducted to characterize S. isolates from clinical cases large-scale herds China. isolated 624 and confirmed by matrix-assisted laser desorption ionization-time flight mass spectrometry (MALDI-TOF MS). In total, 62 were obtained. Cluster analysis, genetic diversity, quantification biofilm formation,...
Mitochondria are cellular organelles that involved in various metabolic processes, and damage to mitochondria can affect cell health even lead disease. Mitophagy is a mechanism by which cells selectively wrap degrade damaged maintain homeostasis. However, studies have not focused on whether mitophagy the occurrence of Staphylococcus aureus (S. aureus)-induced mastitis dairy cows. Here, we found S. infection bovine macrophages leads oxidative damage. The expression LC3, PINK1 Parkin was...